2型糖尿病的发病机制是在胰岛素抵抗的基础上伴有分泌的不足。胰岛素抵抗是指必须以超过正常的血胰岛素释放水平来维持正常的糖耐量,提示机体组织和器官对胰岛素处理葡萄糖的能力减弱。胰岛素抵抗在2型糖尿病血管并发症的发展过程中具...2型糖尿病的发病机制是在胰岛素抵抗的基础上伴有分泌的不足。胰岛素抵抗是指必须以超过正常的血胰岛素释放水平来维持正常的糖耐量,提示机体组织和器官对胰岛素处理葡萄糖的能力减弱。胰岛素抵抗在2型糖尿病血管并发症的发展过程中具有重要的作用。近年众多研究显示,甘油三酯葡萄糖指数是一种可以反映胰岛素抵抗的新指标。现就甘油三酯葡萄糖乘积指数与2型糖尿病血管并发症的研究进展作一综述。The pathogenesis of type 2 diabetes is based on insulin resistance accompanied by insufficient secretion. Insulin resistance is defined as the necessity to maintain normal glucose tolerance at a level of blood insulin release that exceeds normal, suggesting that the body’s tissues and organs have a diminished ability to process glucose by insulin. Insulin resistance has an important role in the development of vascular complications in type 2 diabetes. Numerous studies in recent years have shown that triglyceride glucose index is a new index that can reflect insulin resistance. Now, we would like to make a review on the research progress of triglyceride glucose multiplication index and vascular complications of type 2 diabetes.展开更多
文摘2型糖尿病的发病机制是在胰岛素抵抗的基础上伴有分泌的不足。胰岛素抵抗是指必须以超过正常的血胰岛素释放水平来维持正常的糖耐量,提示机体组织和器官对胰岛素处理葡萄糖的能力减弱。胰岛素抵抗在2型糖尿病血管并发症的发展过程中具有重要的作用。近年众多研究显示,甘油三酯葡萄糖指数是一种可以反映胰岛素抵抗的新指标。现就甘油三酯葡萄糖乘积指数与2型糖尿病血管并发症的研究进展作一综述。The pathogenesis of type 2 diabetes is based on insulin resistance accompanied by insufficient secretion. Insulin resistance is defined as the necessity to maintain normal glucose tolerance at a level of blood insulin release that exceeds normal, suggesting that the body’s tissues and organs have a diminished ability to process glucose by insulin. Insulin resistance has an important role in the development of vascular complications in type 2 diabetes. Numerous studies in recent years have shown that triglyceride glucose index is a new index that can reflect insulin resistance. Now, we would like to make a review on the research progress of triglyceride glucose multiplication index and vascular complications of type 2 diabetes.
文摘目的 评估老年慢性心力衰竭(CHF)中甘油三酯葡萄糖乘积(TyG)指数水平变化,分析与缺血性CHF患者左心室功能相关参数的关系。方法 选取2021年3月至2022年3月在河北省人民医院心血管内科住院确诊的老年CHF患者183例作为CHF组,将CHF组按照是否伴有冠状动脉疾病分为缺血性CHF组117例和非缺血性CHF组66例。选取同期河北省人民医院心血管内科住院的老年非CHF患者58例作为非CHF组。收集各组临床资料、实验室指标以及超声心动图指标,计算TyG指数并分析TyG指数与CHF患者左心室功能相关指标的相关性。结果 CHF组的TyG指数明显高于非CHF组(8.51±0.51 vs 8.18±0.42,P<0.01);缺血性CHF组的TyG指数高于非缺血性CHF组(8.62±0.51 vs 8.30±0.45,P<0.01)。CHF组TyG指数与左心室舒张末期内径(r=0.171,P=0.020)、左心室收缩末期内径(r=0.172,P=0.020)呈显著正相关,与LVEF呈显著负相关(r=-0.175,P=0.018)。缺血性CHF组的TyG指数与LVEF呈显著负相关(r=-0.215,P=0.020)。多因素logistic回归分析显示,TyG指数(OR=200.058,95%CI:1.856~21 561.340,P<0.05)是老年CHF的独立危险因素;TyG指数(OR=4.470,95%CI:1.978~10.098,P<0.01)是老年缺血性CHF的独立危险因素。结论 TyG指数与老年CHF左心室功能相关,并与CHF病因有关。
