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基于肝脏生物力学形变模型的MIM系统配准精度评估
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作者 苟晓芳 冯秀霞 范嵩 《医疗卫生装备》 2025年第2期49-55,共7页
目的:评估MIM系统的生物力学形变配准精度,为肿瘤适应性放疗的治疗响应反馈和剂量叠加等配准需求场景提供配准评估数据支持。方法:首先,将1个含60个金标点的新鲜猪肝在不同加热时长(不同收缩状态)的CT影像作为含金标模体影像,用金标点... 目的:评估MIM系统的生物力学形变配准精度,为肿瘤适应性放疗的治疗响应反馈和剂量叠加等配准需求场景提供配准评估数据支持。方法:首先,将1个含60个金标点的新鲜猪肝在不同加热时长(不同收缩状态)的CT影像作为含金标模体影像,用金标点附近的猪肝组织的像素平均值代替含金标的高密度点的像素值得到不含金标的模体影像。其次,将2种模体影像导入MIM系统中,采用影像形变配准(deformable image registration,DIR)和基于轮廓边界的混合影像形变配准(hybrid deformable image registration,HY-DIR)2种方法进行配准。最后,分别计算所有金标点、23个内部金标点、37个表面金标点配准得到的金标点与真实金标点的目标配准误差(target registration error,TRE)的均值,同时计算Dice系数和Hausdorff距离,并进行含金标DIR、含金标HY-DIR、无金标DIR和无金标HY-DIR这4组组间相关性、差异性检验。采用SPSS 25.0软件进行统计学分析。结果:在30 s时相,TRE均值范围为2.14~2.20 mm,Dice系数均为0.94;在60~90 s时相,TRE均值范围为3.02~5.32 mm,Dice系数为0.95~0.97;在110~200 s时相,TRE均值大于4 mm,Dice系数为0.93~0.96。在30~200 s时相,Hausdorff距离的均值较高,最小值为3.85 mm,最大值为17.91 mm。所有猪肝组织表面金标点的TRE均值和标准差都大于内部金标点。配准方法为DIR时,猪肝组织内部金标点和所有金标点的Dice系数与TRE均值呈中等强度相关(0.4<r<0.6),HY-DIR配准方法的Dice系数与TRE均值则无相关性(r<0.2)。在TRE均值中,含金标DIR和含金标HY-DIR组间差异有统计学意义(P=0.026),含金标DIR和无金标DIR组间差异有统计学意义(P=0.036)。结论:在MIM系统的自适应放疗配准应用中,时相为30 s时可得到较好的配准效果;在时相为60~90 s时(体积收缩低于20%),配准误差相对较小,建议人工检查更正;在时相为110~200 s时(收缩百分比高于20%),配准误差较大。含金标比无金标配准效果更佳,DIR方法比HY-DIR方法更准确。 展开更多
关键词 MIM系统 生物力学形变模型 形变配准 配准精度 适应性放疗
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Experimental Study on Stress Relaxation and Creep Properties of Human Thoracolumbar Vertebral Bodies and Intervertebral Discs
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作者 HUANG Jian-song HUA Hong-xing +1 位作者 WANG Yi-jin CHEN Yong 《Chinese Journal of Biomedical Engineering(English Edition)》 2009年第4期154-161,共8页
Objective:Underwater shock can produce extremely high accelerations, resulting in severe human injuries on shipboard, and human thoraco lumbar spines are prone to suffer from injuries by ship shock motion. To observe ... Objective:Underwater shock can produce extremely high accelerations, resulting in severe human injuries on shipboard, and human thoraco lumbar spines are prone to suffer from injuries by ship shock motion. To observe the viscoelasticity of thoracolumbar of young fresh cadavers, and to provide biomechanical parameters for both research and clinical practice. Materials and Methods:5 fresh young male cadavers (aged 22 to 31 years) were provided, and 15 thoracolumbar spinal anatomies of 5 samples were harvested within 1 hour of death. WE-10A universal testing machine was used for creep and relaxation tests.Results:Stress relaxation and creep deformation equations are derived from the biomechanics model and the measured and simulated curves are compared. The creep in vertebral bodies and intervertebral discs exhibited significantly changes in the first 5 min and 10 min, respectively. The stress rapidly decreased in the first 2 min, and then gradually went balance during the relaxation process. Conclusion:The change in creep rate is significant at early stage,and gradually slows down.This indicates that the differences between internal pressure and local pressure are decreased until balance. The simulated curve derived from equation coincides with the experimental data to a large degree, which states that the equation is rational and reliable. 展开更多
关键词 spine biomechanics functional spinal unit (FSU) vertebral body intervertebral disc stress relaxation creep deformation spring-dashpot
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Deformation and stress distribution of the human foot after plantar ligaments release:A cadaveric study and finite element analysis 被引量:8
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作者 LIANG Jun YANG YunFeng +2 位作者 YU GuangRong NIU WenXin WANG YuBin 《Science China(Life Sciences)》 SCIE CAS 2011年第3期267-271,共5页
The majority of foot deformities are related to arch collapse or instability,especially the longitudinal arch.Although the relationship between the plantar fascia and arch height has been previously investigated,the s... The majority of foot deformities are related to arch collapse or instability,especially the longitudinal arch.Although the relationship between the plantar fascia and arch height has been previously investigated,the stress distribution remains unclear.The aim of this study was to explore the role of the plantar ligaments in foot arch biomechanics.We constructed a geometrical detailed three-dimensional (3-D) finite element (FE) model of the human foot and ankle from computer tomography images.The model comprised the majority of joints in the foot as well as bone segments,major ligaments,and plantar soft tissue.Release of the plantar fascia and other ligaments was simulated to evaluate the corresponding biomechanical effects on load distribution of the bony and ligamentous structures.These intrinsic ligaments of the foot arch were sectioned to simulate different pathologic situations of injury to the plantar ligaments,and to explore bone segment displacement and stress distribution.The validity of the 3-D FE model was verified by comparing results with experimentally measured data via the displacement and von Mise stress of each bone segment.Plantar fascia release decreased arch height,but did not cause total collapse of the foot arch.The longitudinal foot arch was lost when all the four major plantar ligaments were sectioned simultaneously.Plantar fascia release was compromised by increased strain applied to the plantar ligaments and intensified stress in the midfoot and metatarsal bones.Load redistribution among the centralized metatarsal bones and focal stress relief at the calcaneal insertion were predicted.The 3-D FE model indicated that plantar fascia release may provide relief of focal stress and associated heel pain.However,these operative procedures may pose a risk to arch stability and clinically may produce dorsolateral midfoot pain.The initial strategy for treating plantar fasciitis should be non-operative. 展开更多
关键词 BIOMECHANICS finite element analysis foot arch LIGAMENT STRESS
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