本研究采用孟德尔随机化分析探讨精神疾病与胃肠道疾病风险之间的因果关系。利用精神基因组学联盟(PGC)的GWAS数据,选取精神分裂症、重度抑郁症、双相情感障碍和创伤后应激障碍(PTSD)相关的SNP作为工具变量,并结合IEU数据库的胃肠道疾...本研究采用孟德尔随机化分析探讨精神疾病与胃肠道疾病风险之间的因果关系。利用精神基因组学联盟(PGC)的GWAS数据,选取精神分裂症、重度抑郁症、双相情感障碍和创伤后应激障碍(PTSD)相关的SNP作为工具变量,并结合IEU数据库的胃肠道疾病数据,分析其对胃食管反流病(GERD)、胃溃疡、十二指肠溃疡和慢性胃炎的影响。结果显示,重度抑郁症显著增加GERD (OR = 1.505, P = 2.57 × 10−13)和胃溃疡(OR = 1.294, P = 1.48 × 10−4)的风险,而PTSD也增加了GERD的风险(OR = 1.180, P = 0.003),但其他精神疾病与胃肠道疾病之间未发现显著相关性。本研究揭示了重度抑郁症和PTSD对GERD的潜在致病作用,同时发现重度抑郁症可能增加胃溃疡的风险,为精神疾病患者的胃肠道健康管理提供了新的科学依据。This study utilized Mendelian randomization analysis to explore the causal relationship between psychiatric disorders and the risk of gastrointestinal (GIT) diseases. GWAS data from the Psychiatric Genomics Consortium (PGC) were used, selecting SNPs associated with schizophrenia, major depressive disorder, bipolar disorder, and post-traumatic stress disorder (PTSD) as instrumental variables. GIT disease data were obtained from the IEU database to analyze their effects on gastroesophageal reflux disease (GERD), gastric ulcer, duodenal ulcer, and chronic gastritis. The results showed that major depressive disorder significantly increased the risk of GERD (OR = 1.505, P = 2.57 × 10−13) and gastric ulcers (OR = 1.294, P = 1.48 × 10−4), while PTSD also increased the risk of GERD (OR = 1.180, P = 0.003). However, no significant association was found between other psychiatric disorders and GIT diseases. This study highlights the potential pathogenic role of major depressive disorder and PTSD in GERD and suggests that major depressive disorder may also increase the risk of gastric ulcers, providing new scientific evidence for the gastrointestinal health management of psychiatric patients.展开更多
[目的]观察补肺益肾方对肺肾气虚型慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者肺康复的作用。[方法]搜集2021年10月至2023年1月浙江医院确诊的肺肾气虚型COPD稳定期患者55例,随机分成试验组(26例)和对照...[目的]观察补肺益肾方对肺肾气虚型慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者肺康复的作用。[方法]搜集2021年10月至2023年1月浙江医院确诊的肺肾气虚型COPD稳定期患者55例,随机分成试验组(26例)和对照组(29例)。对照组予稳定期吸入剂+肺康复运动训练治疗方案,试验组在此基础上予补肺益肾方加减治疗。评估两组患者治疗前,治疗第4周、第8周的肺功能指标第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、第1秒用力呼气容积占预计值百分比(forced expiratory volume in the first second to predicted values,FEV1%)、第一秒用力呼气容积占用力肺活量比值(forced expiratory volume in one second to forced vital capacity,FEV1/FVC)、慢性阻塞性肺疾病评估测试(chronic obstructive pulmonary disease assessment test,CAT)评分、咳嗽能力评分、咳痰难度评分、体质量指数(body mass index,BMI),并监测患者不良反应情况。[结果]与本组治疗前比较,两组在治疗4周、8周,FEV1、FEV1%均有升高,CAT评分、咳嗽难度均有下降,差异均有统计学意义(P<0.05);BMI、咳嗽能力差异无统计学意义(P>0.05);试验组FEV1/FVC治疗4周差异无统计学意义(P>0.05),治疗8周升高,差异有统计学意义(P<0.05)。与对照组同期比较,试验组在治疗4周、8周,CAT评分降低、咳嗽难度下降,差异均有统计学意义(P<0.05),FEV1、FEV1%、咳嗽能力、BMI差异均无统计学意义(P>0.05);试验组FEV1/FVC在治疗4周差异无统计学意义(P>0.05),治疗8周升高,差异有统计学意义(P<0.05)。[结论]补肺益肾方在COPD稳定期患者中对肺康复起到协同作用。展开更多
文摘本研究采用孟德尔随机化分析探讨精神疾病与胃肠道疾病风险之间的因果关系。利用精神基因组学联盟(PGC)的GWAS数据,选取精神分裂症、重度抑郁症、双相情感障碍和创伤后应激障碍(PTSD)相关的SNP作为工具变量,并结合IEU数据库的胃肠道疾病数据,分析其对胃食管反流病(GERD)、胃溃疡、十二指肠溃疡和慢性胃炎的影响。结果显示,重度抑郁症显著增加GERD (OR = 1.505, P = 2.57 × 10−13)和胃溃疡(OR = 1.294, P = 1.48 × 10−4)的风险,而PTSD也增加了GERD的风险(OR = 1.180, P = 0.003),但其他精神疾病与胃肠道疾病之间未发现显著相关性。本研究揭示了重度抑郁症和PTSD对GERD的潜在致病作用,同时发现重度抑郁症可能增加胃溃疡的风险,为精神疾病患者的胃肠道健康管理提供了新的科学依据。This study utilized Mendelian randomization analysis to explore the causal relationship between psychiatric disorders and the risk of gastrointestinal (GIT) diseases. GWAS data from the Psychiatric Genomics Consortium (PGC) were used, selecting SNPs associated with schizophrenia, major depressive disorder, bipolar disorder, and post-traumatic stress disorder (PTSD) as instrumental variables. GIT disease data were obtained from the IEU database to analyze their effects on gastroesophageal reflux disease (GERD), gastric ulcer, duodenal ulcer, and chronic gastritis. The results showed that major depressive disorder significantly increased the risk of GERD (OR = 1.505, P = 2.57 × 10−13) and gastric ulcers (OR = 1.294, P = 1.48 × 10−4), while PTSD also increased the risk of GERD (OR = 1.180, P = 0.003). However, no significant association was found between other psychiatric disorders and GIT diseases. This study highlights the potential pathogenic role of major depressive disorder and PTSD in GERD and suggests that major depressive disorder may also increase the risk of gastric ulcers, providing new scientific evidence for the gastrointestinal health management of psychiatric patients.
文摘[目的]观察补肺益肾方对肺肾气虚型慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期患者肺康复的作用。[方法]搜集2021年10月至2023年1月浙江医院确诊的肺肾气虚型COPD稳定期患者55例,随机分成试验组(26例)和对照组(29例)。对照组予稳定期吸入剂+肺康复运动训练治疗方案,试验组在此基础上予补肺益肾方加减治疗。评估两组患者治疗前,治疗第4周、第8周的肺功能指标第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、第1秒用力呼气容积占预计值百分比(forced expiratory volume in the first second to predicted values,FEV1%)、第一秒用力呼气容积占用力肺活量比值(forced expiratory volume in one second to forced vital capacity,FEV1/FVC)、慢性阻塞性肺疾病评估测试(chronic obstructive pulmonary disease assessment test,CAT)评分、咳嗽能力评分、咳痰难度评分、体质量指数(body mass index,BMI),并监测患者不良反应情况。[结果]与本组治疗前比较,两组在治疗4周、8周,FEV1、FEV1%均有升高,CAT评分、咳嗽难度均有下降,差异均有统计学意义(P<0.05);BMI、咳嗽能力差异无统计学意义(P>0.05);试验组FEV1/FVC治疗4周差异无统计学意义(P>0.05),治疗8周升高,差异有统计学意义(P<0.05)。与对照组同期比较,试验组在治疗4周、8周,CAT评分降低、咳嗽难度下降,差异均有统计学意义(P<0.05),FEV1、FEV1%、咳嗽能力、BMI差异均无统计学意义(P>0.05);试验组FEV1/FVC在治疗4周差异无统计学意义(P>0.05),治疗8周升高,差异有统计学意义(P<0.05)。[结论]补肺益肾方在COPD稳定期患者中对肺康复起到协同作用。
