京都心脏研究：缬沙坦对伴有高危因素的高血压患者心血管疾病发病率和死亡率的影响（Rationale and design of the KYOTO HEART study：effects of valsartan on morbidity and nortality in uncontrolled hypertensive patients with h...京都心脏研究：缬沙坦对伴有高危因素的高血压患者心血管疾病发病率和死亡率的影响（Rationale and design of the KYOTO HEART study：effects of valsartan on morbidity and nortality in uncontrolled hypertensive patients with high risk of cardiovaseular events）在（Journal of Human Hypertension 2009，23，188—195）发表，并于2009年8月31日在欧洲心脏病大会（ESC）在线公布结果。展开更多
Background: Focal outbreaks of sexually transmitted infections (STIs) such as syphilis and gonorrhoea have been reported in the large cities of Western Europe over the past few years. The aim of our study was to deter...Background: Focal outbreaks of sexually transmitted infections (STIs) such as syphilis and gonorrhoea have been reported in the large cities of Western Europe over the past few years. The aim of our study was to determine whether a similar trend is observed in Geneva and the situation with regard to HIV infection. Methods: We review the incidence of syphilis, gonorrhoea, Chlamydia trachomatis and HIV in Geneva from 1999 to 2004. Results: Figures indicate a steady and sustained increase in the incidence of syphilis, gonorrhoea and Chlamydia trachomatis in Geneva since 1999 that is maintained into 2004. As for HIV, the number of positive testings in Switzerland has stabilised and primary infection figures do not indicate an increase in newly acquired infections in Geneva. Conclusion: The situation in Geneva is similar to that observed elsewhere inWestern Europe and indicates the need of public health interventions.展开更多
Aims: The goal of this study was to assess the prevalence of left ventricular( LV) hypertrophy in patients with aortic stenosis late(>6 months) after aortic va lve replacement and its impact on cardiac-related morb...Aims: The goal of this study was to assess the prevalence of left ventricular( LV) hypertrophy in patients with aortic stenosis late(>6 months) after aortic va lve replacement and its impact on cardiac-related morbidity and mortality. Meth ods and results: In a single tertiary centre, echocardiographic data of LV muscl e mass were collected. Detailed information of medical history and angiographic data were gathered. Ninety-nine of 213 patients(46%) had LV hypertrophy late(m ean 5.8±5.4 years) after aortic valve replacement. LV hypertrophy was associate d with impaired exercise capacity, higher New York Heart Association dyspnoea cl ass, a tendency for more frequent chest pain expressed as higher Canadian Cardio vascular Society class, and more rehospitalizations. 24%of patients with normal LV mass vs. 39%of patients with LV hypertrophy reported cardiac-related morbi dity(p=0.04). In a multivariate logistic regression model, LV hypertrophy was an independent predictor of cardiac-related morbidity(odds ratio 2.31, 95%CI 1.0 8 to 5.41), after correction for gender, baseline ejection fraction, and coronar y artery disease and its risk factors. Thirty seven deaths occurred during a tot al of 1959 patient years of follow-up(mean follow-up 9.6 years). Age at aortic valve replacement(hazard ratio 1.85, 95%CI 1.39 to 2.47, for every 5 years inc rease in age), coexisting coronary artery disease at the time of surgery(hazard ratio 3.36, 95%CI 1.31 to 8.62), and smoking(hazard ratio 4.82, 95%CI 1.72 to 13.45) were independent predictors of overall mortality late after surgery, but not LV hypertrophy. Conclusions: In patients with aortic valve replacement for i solated aortic stenosis, LV hypertrophy late after surgery is associated with in creased morbidity.展开更多
Background: Diminished lung function appears to be a risk factor for respirato ry syncytial virus (RSV) infection/bronchiolitis in term born infants. Aims: To determine if diminished lung function prior to neonatal un...Background: Diminished lung function appears to be a risk factor for respirato ry syncytial virus (RSV) infection/bronchiolitis in term born infants. Aims: To determine if diminished lung function prior to neonatal unit discharge was assoc iated with subsequent symptomatic RSV lower respiratory tract infection (LRTI) a nd respiratory morbidity in prematurely born infants. Methods: Of 39 infants in a tertiary neonatal intensive care unit (median gestational age 28 weeks, range 23-31), 20 had bronchopulmonary dysplasia. Lung function (compliance and resist ance of the respiratory system(Crs and R rs) and functional residual capacity (F RC)) was measured on the neonatal unit at 36 weeks postmenstrual age (PMA). Foll owing neonatal unit discharge, nasopharyngeal aspirates were obtained on every o ccasion, at home or in hospital, an infant had an LRTI. RSV was identified by im munofluorescence and/or culture. Results: The 15 infants who suffered a symptoma tic RSV LRTI had a higher mean Rrs and suffered more wheeze at follow up than th e rest of the cohort. Regression analysis showed that a high Rrs was significant ly associated with a symptomatic RSV LRTI; significant factors for cough were a high Rrs and a symptomatic RSV LRTI, and for wheeze were a high Rrs. Conclusion: Prematurely born infants, who had a symptomatic RSV LRTI and/or respiratory mor bidity at follow up, had worse lung function prior to neonatal unit discharge.展开更多
文摘京都心脏研究：缬沙坦对伴有高危因素的高血压患者心血管疾病发病率和死亡率的影响（Rationale and design of the KYOTO HEART study：effects of valsartan on morbidity and nortality in uncontrolled hypertensive patients with high risk of cardiovaseular events）在（Journal of Human Hypertension 2009，23，188—195）发表，并于2009年8月31日在欧洲心脏病大会（ESC）在线公布结果。
文摘Background: Focal outbreaks of sexually transmitted infections (STIs) such as syphilis and gonorrhoea have been reported in the large cities of Western Europe over the past few years. The aim of our study was to determine whether a similar trend is observed in Geneva and the situation with regard to HIV infection. Methods: We review the incidence of syphilis, gonorrhoea, Chlamydia trachomatis and HIV in Geneva from 1999 to 2004. Results: Figures indicate a steady and sustained increase in the incidence of syphilis, gonorrhoea and Chlamydia trachomatis in Geneva since 1999 that is maintained into 2004. As for HIV, the number of positive testings in Switzerland has stabilised and primary infection figures do not indicate an increase in newly acquired infections in Geneva. Conclusion: The situation in Geneva is similar to that observed elsewhere inWestern Europe and indicates the need of public health interventions.
文摘Aims: The goal of this study was to assess the prevalence of left ventricular( LV) hypertrophy in patients with aortic stenosis late(>6 months) after aortic va lve replacement and its impact on cardiac-related morbidity and mortality. Meth ods and results: In a single tertiary centre, echocardiographic data of LV muscl e mass were collected. Detailed information of medical history and angiographic data were gathered. Ninety-nine of 213 patients(46%) had LV hypertrophy late(m ean 5.8±5.4 years) after aortic valve replacement. LV hypertrophy was associate d with impaired exercise capacity, higher New York Heart Association dyspnoea cl ass, a tendency for more frequent chest pain expressed as higher Canadian Cardio vascular Society class, and more rehospitalizations. 24%of patients with normal LV mass vs. 39%of patients with LV hypertrophy reported cardiac-related morbi dity(p=0.04). In a multivariate logistic regression model, LV hypertrophy was an independent predictor of cardiac-related morbidity(odds ratio 2.31, 95%CI 1.0 8 to 5.41), after correction for gender, baseline ejection fraction, and coronar y artery disease and its risk factors. Thirty seven deaths occurred during a tot al of 1959 patient years of follow-up(mean follow-up 9.6 years). Age at aortic valve replacement(hazard ratio 1.85, 95%CI 1.39 to 2.47, for every 5 years inc rease in age), coexisting coronary artery disease at the time of surgery(hazard ratio 3.36, 95%CI 1.31 to 8.62), and smoking(hazard ratio 4.82, 95%CI 1.72 to 13.45) were independent predictors of overall mortality late after surgery, but not LV hypertrophy. Conclusions: In patients with aortic valve replacement for i solated aortic stenosis, LV hypertrophy late after surgery is associated with in creased morbidity.
文摘Background: Diminished lung function appears to be a risk factor for respirato ry syncytial virus (RSV) infection/bronchiolitis in term born infants. Aims: To determine if diminished lung function prior to neonatal unit discharge was assoc iated with subsequent symptomatic RSV lower respiratory tract infection (LRTI) a nd respiratory morbidity in prematurely born infants. Methods: Of 39 infants in a tertiary neonatal intensive care unit (median gestational age 28 weeks, range 23-31), 20 had bronchopulmonary dysplasia. Lung function (compliance and resist ance of the respiratory system(Crs and R rs) and functional residual capacity (F RC)) was measured on the neonatal unit at 36 weeks postmenstrual age (PMA). Foll owing neonatal unit discharge, nasopharyngeal aspirates were obtained on every o ccasion, at home or in hospital, an infant had an LRTI. RSV was identified by im munofluorescence and/or culture. Results: The 15 infants who suffered a symptoma tic RSV LRTI had a higher mean Rrs and suffered more wheeze at follow up than th e rest of the cohort. Regression analysis showed that a high Rrs was significant ly associated with a symptomatic RSV LRTI; significant factors for cough were a high Rrs and a symptomatic RSV LRTI, and for wheeze were a high Rrs. Conclusion: Prematurely born infants, who had a symptomatic RSV LRTI and/or respiratory mor bidity at follow up, had worse lung function prior to neonatal unit discharge.
