Considering epidemiological,genetic and immunological data,we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact t...Considering epidemiological,genetic and immunological data,we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease.It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation.Several genes have been so far related to the diagnosis of Crohn's disease.Those genes are related to innate pattern recognition receptors,to epithelial barrier homeostasis and maintenance of epithelial barrier integrity,to autophagy and to lymphocyte differentiation.So far,the most strong and replicated associations with Crohn's disease have been done with NOD2,IL23R and ATG16L1 genes.Many genes have so far been implicated in prognosis of Crohn's disease and many attempts have been made to classify genetic profiles in Crohn's disease.CARD15 seems not only a susceptibility gene,but also a disease-modifier gene for Crohn's disease.Enriching our understanding on Crohn's disease genetics is important but when combining genetic data with functional data the outcome could be of major importance to clinicians.展开更多
Exploration of influential people is really a hot issue for effective viral marketing these days. Prior studies overlooked to consider the influence of interaction between users and the authority of users during infor...Exploration of influential people is really a hot issue for effective viral marketing these days. Prior studies overlooked to consider the influence of interaction between users and the authority of users during information dissemination. In this article, we proposed an innovative concept by employing communication strength and authority in order to explore the influential people. First, we calculated communication strength by three kinds of actions including retweets, comments and mentions. Second, we deliberated authority metric by employing total times getting re-tweeted, number of tweets and followers of a user. Then, we propose a novel algorithm called Influential People Label Propagation Algorithm(IPLPA) that considers the proposed metric to explore the influential people in micro-blog networks. We performed extensive experiments to measure the influence and rank of each person within micro-blog network. The comparative study presents that IPLPA depicted effective people while baseline algorithms retrieved low influenced people at top rank. Additionally, influence dissemination also measured for obtained influential people in order to validate proposed concept. The findings of this study would be useful for viral marketing and advertisement campaigns.展开更多
文摘Considering epidemiological,genetic and immunological data,we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease.It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation.Several genes have been so far related to the diagnosis of Crohn's disease.Those genes are related to innate pattern recognition receptors,to epithelial barrier homeostasis and maintenance of epithelial barrier integrity,to autophagy and to lymphocyte differentiation.So far,the most strong and replicated associations with Crohn's disease have been done with NOD2,IL23R and ATG16L1 genes.Many genes have so far been implicated in prognosis of Crohn's disease and many attempts have been made to classify genetic profiles in Crohn's disease.CARD15 seems not only a susceptibility gene,but also a disease-modifier gene for Crohn's disease.Enriching our understanding on Crohn's disease genetics is important but when combining genetic data with functional data the outcome could be of major importance to clinicians.
基金supported in part by the following funding agencies of China:National Natural Science Foundation under Grant 61170274,61602050 and U1534201
文摘Exploration of influential people is really a hot issue for effective viral marketing these days. Prior studies overlooked to consider the influence of interaction between users and the authority of users during information dissemination. In this article, we proposed an innovative concept by employing communication strength and authority in order to explore the influential people. First, we calculated communication strength by three kinds of actions including retweets, comments and mentions. Second, we deliberated authority metric by employing total times getting re-tweeted, number of tweets and followers of a user. Then, we propose a novel algorithm called Influential People Label Propagation Algorithm(IPLPA) that considers the proposed metric to explore the influential people in micro-blog networks. We performed extensive experiments to measure the influence and rank of each person within micro-blog network. The comparative study presents that IPLPA depicted effective people while baseline algorithms retrieved low influenced people at top rank. Additionally, influence dissemination also measured for obtained influential people in order to validate proposed concept. The findings of this study would be useful for viral marketing and advertisement campaigns.
