Objective:To characterize diurnal intraocular pressure (IOP)-changes in primary open-angle glaucoma by reproducing IOPs based on patient posture. Methods: In 148 patients with untreated primary open-angle glaucoma who...Objective:To characterize diurnal intraocular pressure (IOP)-changes in primary open-angle glaucoma by reproducing IOPs based on patient posture. Methods: In 148 patients with untreated primary open-angle glaucoma who had IOPs recorded during clinic hours that were less than 21 mm Hg (average,14.8± 3.2 mm Hg),we measured IOP by noncontact tonometry every 2 hours from 6 AM to midnight and every 3 hours from midnight to 6 AM with patients sitting and supine. The IOP was reproduced by designating the sitting IOP as measurements taken when the patient was awake and the supine IOP as measurements taken when the patient was asleep for each individual. The reproduced diurnal IOP was composed of 12 measurements that included 2 to 4 IOP levels measured with the patients supine and the rest while they were sitting. Results: The peak of sitting diurnal IOP (mean± SD) for 148 patients was 16.0± 2.7 mm Hg,which was significantly lower than the peak of supine IOP (18.9± 3.9 mm Hg) or the reproduced IOP (17.5± 3.6 mm Hg) (P < .001 for both comparisons). The average reproduced IOP at each measurement time peaked at 3 AM during sleep; with sitting diurnal IOP or supine diurnal IOP,the peak IOPs were at noon. Twenty-nine patients (20% ) with an IOP less than 21mmHg during clinic hours had a reproduced IOP of 21mmHg or greater while asleep,compared with only 5 patients (3% ) when the patients were sitting only. Conclusions: In patients with primary open-angle glaucoma and IOPs less than 21 mm Hg during clinic hours,20% of patients had a reproduced IOP of 21 mm Hg or greater,compared with only 3% who had an IOP of 21 mm Hg or greater while sitting. Intraocular pressures peaked in most patients during sleep.展开更多
PURPOSE: The aim of this study was to develop a predictive model based on preoperative variables for estimating postoperative intraocular pressure (IOP) of those eyes undergoing LASIK surgery,to predict the amount of ...PURPOSE: The aim of this study was to develop a predictive model based on preoperative variables for estimating postoperative intraocular pressure (IOP) of those eyes undergoing LASIK surgery,to predict the amount of underestimated IOP after LASIK for myopia and myopic astigmatism. DESIGN: Pretest-post-test longitudinal study. METHODS: Both eyes of 193 eligible subjects who underwent LASIK procedures at the Department of Ophthalmology,National Taiwan University Hospital,from July 2000 to December 2002 for myopia and myopic astigmatism were identified to build up the predictive models. IOPs were measured with noncontact air-puff tonometry. Information on age,gender,preoperative central corneal thickness (CCT),preoperative central corneal curvature (CCK),preoperative spherical equivalent refractive error,and ablation depth was collected and applied for predicting postoperative IOP after LASIK based on linear mixed model. RESULTS: Significant predictors for postoperative IOP after myopic LASIK procedures included age,gender,preoperative IOP,ablation depth,preoperativeCCT,and preoperative spherical equivalent refractive errors. The linear mixed model,taking into account these significant preoperative correlates and the correlation of IOPs between both eyes of the same patient,explained 91% of the variation of postoperative IOP. CONCLUSIONS: A statistical model was developed for predicting the amount of underestimated IOP after LASIK for myopia and myopic astigmatism,which is of clinical importance to uncover ocular hypertension among patients whose information on postoperative IOP immediately after LASIK is not available.展开更多
Objective:We evaluated the correlation between intracranial(ICP)and intraocular pressure(IOP).Methods:Of the 77 patients who underwent a lumbar puncture,27 were excluded secondary to a history of glaucoma,using drugs ...Objective:We evaluated the correlation between intracranial(ICP)and intraocular pressure(IOP).Methods:Of the 77 patients who underwent a lumbar puncture,27 were excluded secondary to a history of glaucoma,using drugs effective on IOP,and abnormal funduscopic examination.ICP was measured by lumbar puncture.IOP was measured by two scales of Schiotz tonometer in both eyes,and the mean was calculated.Results:We found a significant correlation between ICP and mean IOP(p< 0.001;r=0.955).Body mass index,age,and disease type had no significant effect on this correlation.Interpretation:IOP is correlated with ICP.展开更多
文摘Objective:To characterize diurnal intraocular pressure (IOP)-changes in primary open-angle glaucoma by reproducing IOPs based on patient posture. Methods: In 148 patients with untreated primary open-angle glaucoma who had IOPs recorded during clinic hours that were less than 21 mm Hg (average,14.8± 3.2 mm Hg),we measured IOP by noncontact tonometry every 2 hours from 6 AM to midnight and every 3 hours from midnight to 6 AM with patients sitting and supine. The IOP was reproduced by designating the sitting IOP as measurements taken when the patient was awake and the supine IOP as measurements taken when the patient was asleep for each individual. The reproduced diurnal IOP was composed of 12 measurements that included 2 to 4 IOP levels measured with the patients supine and the rest while they were sitting. Results: The peak of sitting diurnal IOP (mean± SD) for 148 patients was 16.0± 2.7 mm Hg,which was significantly lower than the peak of supine IOP (18.9± 3.9 mm Hg) or the reproduced IOP (17.5± 3.6 mm Hg) (P < .001 for both comparisons). The average reproduced IOP at each measurement time peaked at 3 AM during sleep; with sitting diurnal IOP or supine diurnal IOP,the peak IOPs were at noon. Twenty-nine patients (20% ) with an IOP less than 21mmHg during clinic hours had a reproduced IOP of 21mmHg or greater while asleep,compared with only 5 patients (3% ) when the patients were sitting only. Conclusions: In patients with primary open-angle glaucoma and IOPs less than 21 mm Hg during clinic hours,20% of patients had a reproduced IOP of 21 mm Hg or greater,compared with only 3% who had an IOP of 21 mm Hg or greater while sitting. Intraocular pressures peaked in most patients during sleep.
文摘PURPOSE: The aim of this study was to develop a predictive model based on preoperative variables for estimating postoperative intraocular pressure (IOP) of those eyes undergoing LASIK surgery,to predict the amount of underestimated IOP after LASIK for myopia and myopic astigmatism. DESIGN: Pretest-post-test longitudinal study. METHODS: Both eyes of 193 eligible subjects who underwent LASIK procedures at the Department of Ophthalmology,National Taiwan University Hospital,from July 2000 to December 2002 for myopia and myopic astigmatism were identified to build up the predictive models. IOPs were measured with noncontact air-puff tonometry. Information on age,gender,preoperative central corneal thickness (CCT),preoperative central corneal curvature (CCK),preoperative spherical equivalent refractive error,and ablation depth was collected and applied for predicting postoperative IOP after LASIK based on linear mixed model. RESULTS: Significant predictors for postoperative IOP after myopic LASIK procedures included age,gender,preoperative IOP,ablation depth,preoperativeCCT,and preoperative spherical equivalent refractive errors. The linear mixed model,taking into account these significant preoperative correlates and the correlation of IOPs between both eyes of the same patient,explained 91% of the variation of postoperative IOP. CONCLUSIONS: A statistical model was developed for predicting the amount of underestimated IOP after LASIK for myopia and myopic astigmatism,which is of clinical importance to uncover ocular hypertension among patients whose information on postoperative IOP immediately after LASIK is not available.
文摘Objective:We evaluated the correlation between intracranial(ICP)and intraocular pressure(IOP).Methods:Of the 77 patients who underwent a lumbar puncture,27 were excluded secondary to a history of glaucoma,using drugs effective on IOP,and abnormal funduscopic examination.ICP was measured by lumbar puncture.IOP was measured by two scales of Schiotz tonometer in both eyes,and the mean was calculated.Results:We found a significant correlation between ICP and mean IOP(p< 0.001;r=0.955).Body mass index,age,and disease type had no significant effect on this correlation.Interpretation:IOP is correlated with ICP.
