Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibit...Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects展开更多
Purpose: To investigate the interactions between muscarinic and beta-adrenergic drugs in the iris sphincter relaxation Methods: Intact bovine iris sphincters were incubated in organ bath and challenged with appropriat...Purpose: To investigate the interactions between muscarinic and beta-adrenergic drugs in the iris sphincter relaxation Methods: Intact bovine iris sphincters were incubated in organ bath and challenged with appropriate beta-adrenergic agonists and/or muscarinic antagonists. Tension was measured by a force trans-展开更多
文摘Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects
文摘Purpose: To investigate the interactions between muscarinic and beta-adrenergic drugs in the iris sphincter relaxation Methods: Intact bovine iris sphincters were incubated in organ bath and challenged with appropriate beta-adrenergic agonists and/or muscarinic antagonists. Tension was measured by a force trans-
