Plaque formation is a characteristic finding in patients with psoriasis and re flects cytokine-induced keratinocyte proliferation and/or impaired apoptosis of keratinocytes. Antithyroid thioureylenes such as propylthi...Plaque formation is a characteristic finding in patients with psoriasis and re flects cytokine-induced keratinocyte proliferation and/or impaired apoptosis of keratinocytes. Antithyroid thioureylenes such as propylthiouracil (PTU) and met himazole (MMI) are effective in the treatment of plaque psoriasis. Following PTU and MMI treatment, proliferative cell nuclear antigen (PCNA) expression is sign ificantly reduced, suggesting that these medications have an antiproliferative effect. p 16 is an antiapoptotic protein that is present in relative abundance in psoriati c plaques and is believed to play a potential role in the persistent senescence and impaired apoptosis of the keratinocytes in the plaque. This study examined p 16 expression in biopsy samples of eight patients with plaque psoriasis given 30 0 mg of propylthiouracil in divided doses for 3 months. Despite significant clin ical and histological improvement with PTUtreatment,p16expressionwasessentiallyu nchanged,suggesting that the beneficial effect of PTU in psoriasis is not mediat ed through a decrease in p16 expression. The effect of PTU on other antiapoptoti c proteins such as bcl-xL remains to be determined.展开更多
文摘Plaque formation is a characteristic finding in patients with psoriasis and re flects cytokine-induced keratinocyte proliferation and/or impaired apoptosis of keratinocytes. Antithyroid thioureylenes such as propylthiouracil (PTU) and met himazole (MMI) are effective in the treatment of plaque psoriasis. Following PTU and MMI treatment, proliferative cell nuclear antigen (PCNA) expression is sign ificantly reduced, suggesting that these medications have an antiproliferative effect. p 16 is an antiapoptotic protein that is present in relative abundance in psoriati c plaques and is believed to play a potential role in the persistent senescence and impaired apoptosis of the keratinocytes in the plaque. This study examined p 16 expression in biopsy samples of eight patients with plaque psoriasis given 30 0 mg of propylthiouracil in divided doses for 3 months. Despite significant clin ical and histological improvement with PTUtreatment,p16expressionwasessentiallyu nchanged,suggesting that the beneficial effect of PTU in psoriasis is not mediat ed through a decrease in p16 expression. The effect of PTU on other antiapoptoti c proteins such as bcl-xL remains to be determined.
