A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma.Prior biopsies obtained from ...A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma.Prior biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without dysplasia.Although operator-dependent,repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course.展开更多
Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is stil...Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.展开更多
Wnts are a highly conserved family of Upid-modified glycoproteins that work as morphogens to activate several signaling pathways, leading to remodeling of the cytoskeleton and the regulation of gene transcription. Wnt...Wnts are a highly conserved family of Upid-modified glycoproteins that work as morphogens to activate several signaling pathways, leading to remodeling of the cytoskeleton and the regulation of gene transcription. Wnt signaling regulates multiple cellular functions and cell systems, including the development and maintenance of midbrain dopaminergic （m DA） neurons. These neurons are of consid- erable interest for regenerative medicine because their degeneration results in Parkinson＇s disease （PD）. This review focuses on new advances in understanding key functions of Wnts in mDA neuron development and using novel tools to regulate Wnt signaling in re- generative medicine for PD. Particularly, recent reports indicate that appropriate levels of Wnt signaling are essential to improve the quantity and quality of stem ceil- or reprogrammed ceU-derived mDA neurons to be used in drug discovery and cell replacement therapy for PD.展开更多
文摘A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma.Prior biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without dysplasia.Although operator-dependent,repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course.
基金Project supported by the National Natural Science Foundation of China(Nos.81472504,81401822,and 81572177)the Science and Technology Foundation of Zhejiang Province(No.2016C33151)+1 种基金the Medical Science and Technology Project of Zhejiang Province of China(Nos.2016146428,2016KYA096,and 2017KY071)the Zhejiang Provincial Natural Science Foundation of China(Nos.Y17H160033,LQ14H060002,and LY14H060004)
文摘Spinal cord injury(SCI),which is much in the public eye,is still a refractory disease compromising the well-being of both patients and society.In spite of there being many methods dealing with the lesion,there is still a deficiency in comprehensive strategies covering all facets of this damage.Further,we should also mention the structure called the corticospinal tract(CST)which plays a crucial role in the motor responses of organisms,and it will be the focal point of our attention.In this review,we discuss a variety of strategies targeting different dimensions following SCI and some treatments that are especially efficacious to the CST are emphasized.Over recent decades,researchers have developed many effective tactics involving five approaches:(1)tackle more extensive regions;(2)provide a regenerative microenvironment;(3)provide a glial microenvironment;(4)transplantation;and(5)other auxiliary methods,for instance,rehabilitation training and electrical stimulation.We review the basic knowledge on this disease and correlative treatments.In addition,some well-formulated perspectives and hypotheses have been delineated.We emphasize that such a multifaceted problem needs combinatorial approaches,and we analyze some discrepancies in past studies.Finally,for the future,we present numerous brand-new latent tactics which have great promise for curbing SCI.
文摘Wnts are a highly conserved family of Upid-modified glycoproteins that work as morphogens to activate several signaling pathways, leading to remodeling of the cytoskeleton and the regulation of gene transcription. Wnt signaling regulates multiple cellular functions and cell systems, including the development and maintenance of midbrain dopaminergic （m DA） neurons. These neurons are of consid- erable interest for regenerative medicine because their degeneration results in Parkinson＇s disease （PD）. This review focuses on new advances in understanding key functions of Wnts in mDA neuron development and using novel tools to regulate Wnt signaling in re- generative medicine for PD. Particularly, recent reports indicate that appropriate levels of Wnt signaling are essential to improve the quantity and quality of stem ceil- or reprogrammed ceU-derived mDA neurons to be used in drug discovery and cell replacement therapy for PD.
