Successful innovation is so important that enterprise scientifically manages the process and risk of technological innovation. Firstly, the process of innovation is generalized to seven stages including formation of i...Successful innovation is so important that enterprise scientifically manages the process and risk of technological innovation. Firstly, the process of innovation is generalized to seven stages including formation of innovation idea, investigation and evaluation, research and development, middle test, mass production, marketing and selling, after service and feedback. Secondly, the origin of risk in the process of innovation is analyzed. The purpose is to help enterprise identify risk and take countermeasure to minimize the potential loss and maximize the potential income.展开更多
There is an intrinsic traction force in the technological development which has various manifestations. It is from nonlinear interaction that occurs among the essential elements of technology and among the relevant te...There is an intrinsic traction force in the technological development which has various manifestations. It is from nonlinear interaction that occurs among the essential elements of technology and among the relevant technology. It is not the only decisive factor but to interweave with other tensions in the development of technology.展开更多
Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Followin...Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Following 20 years of developments, GLP system has already been established in this country. This review firstly evaluated all the institutions in this field, and described the annual number and total number of institutions, the distribution of GLP institutions, the types of GLP institutions, and the service provided by these GLP institutions. Since the initiation of the National Key Technology R＆D Program during the 11 th Five-Year Plan, it had a significant effect on the development of GLP. Therefore, the institutions which have undertaken projects from this program will be introduced later. We also described the infrastructure of hardware and software in GLP institutions along with their faults, such as variation in development and the lack of innovation.展开更多
OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study wa...OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study was conducted in 399 patients after resection of small HCC who were admitted between January 1987 and December 2008 in the Department of Hepatobiliary Surgery and Center of Minimlly Invasive Surgery,First Affiliated Hospital of Guangxi Medical University.Four groups were based on different therapy modes:a TCM-only(TCMO) group,a TCM combined with interventional therapy(TCM-IT) group,an interventional therapy-only(ITO) group,and a simple operation(SO) group.Prognostic factors were correlated with overall survival(OS) and OS rates were calculated with the Kaplan-Meier method,and multivariate analyses for factors affecting survival were evaluated by the Cox proportional hazard model.RESULTS:The median OS was 151.20 months in the TCM-IT group,43.87 months in the ITO group,and 20.77 months in the SO group.All survival rates of the TCMO group were higher than those of the other three groups(>50%).The 5-,10-,and 15-year OS in the TCMO and ITO patients were 83.94%,45.50%,and 71.22% and 33.34%,55.58%,and 9.26%,respectively(risk ratio,0.209;95% confidence interval,0.126-0.347;P=0.000).Multivariate analysis revealed that the independent risk factors were therapy mode(P=0.000),sex(P=0.005),family history(P=0.011),TNM Classification of Malignant Tumor staging(P=0.000),medical care-seeking behavior(P=0.021),and maximum diameter(P=0.030).CONCLUSION:Long-term oral use of compound RJH tablets may improve OS for small HCC after resection compared with IT.展开更多
Responsible research and innovation （RRI） represents a new evotvtng approach to governing research and innovation that takes into account potential impacts on the environment and society. Most published studies on R...Responsible research and innovation （RRI） represents a new evotvtng approach to governing research and innovation that takes into account potential impacts on the environment and society. Most published studies on RRI focus on the social benefits of research and innovation through examining RRI＇s definitions and approaches for its implementation. In contrast, the present study addresses the influence of RRI on economic growth, and discusses the situations in which RRI will benefit economies. Our study finds that for its implementation to be successful RRI needs to meet certain conditions, and that its implementation is not always beneficial to economic growth. To achieve a better result from RRI as part of an innovation policy, each country should balance the push and pull power of RRI to make sure that it becomes a building block rather than a stumbling block for innovation, economic growth and social welfare. To assure that RRI can be successfully implemented, China needs to strengthen and improve the participation mechanisms for stakeholders in major scientific and technological innovative activities.展开更多
文摘Successful innovation is so important that enterprise scientifically manages the process and risk of technological innovation. Firstly, the process of innovation is generalized to seven stages including formation of innovation idea, investigation and evaluation, research and development, middle test, mass production, marketing and selling, after service and feedback. Secondly, the origin of risk in the process of innovation is analyzed. The purpose is to help enterprise identify risk and take countermeasure to minimize the potential loss and maximize the potential income.
文摘There is an intrinsic traction force in the technological development which has various manifestations. It is from nonlinear interaction that occurs among the essential elements of technology and among the relevant technology. It is not the only decisive factor but to interweave with other tensions in the development of technology.
基金National Special Project Funds(Grant No.2012ZX09302,2013ZX09302)
文摘Good laboratory practice（GLP） plays an important role in pre-clinical studies, which are a key stage in new drug research and development（R＆D）. The development of GLP in China started in the late 1990 s. Following 20 years of developments, GLP system has already been established in this country. This review firstly evaluated all the institutions in this field, and described the annual number and total number of institutions, the distribution of GLP institutions, the types of GLP institutions, and the service provided by these GLP institutions. Since the initiation of the National Key Technology R＆D Program during the 11 th Five-Year Plan, it had a significant effect on the development of GLP. Therefore, the institutions which have undertaken projects from this program will be introduced later. We also described the infrastructure of hardware and software in GLP institutions along with their faults, such as variation in development and the lack of innovation.
基金Supported by Grants from the 11th National Key Technology R&D Program(No.2006BAI04A06)E-institutes of Shanghai Municipal Education Commission Support Program(No.E03008)
文摘OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study was conducted in 399 patients after resection of small HCC who were admitted between January 1987 and December 2008 in the Department of Hepatobiliary Surgery and Center of Minimlly Invasive Surgery,First Affiliated Hospital of Guangxi Medical University.Four groups were based on different therapy modes:a TCM-only(TCMO) group,a TCM combined with interventional therapy(TCM-IT) group,an interventional therapy-only(ITO) group,and a simple operation(SO) group.Prognostic factors were correlated with overall survival(OS) and OS rates were calculated with the Kaplan-Meier method,and multivariate analyses for factors affecting survival were evaluated by the Cox proportional hazard model.RESULTS:The median OS was 151.20 months in the TCM-IT group,43.87 months in the ITO group,and 20.77 months in the SO group.All survival rates of the TCMO group were higher than those of the other three groups(>50%).The 5-,10-,and 15-year OS in the TCMO and ITO patients were 83.94%,45.50%,and 71.22% and 33.34%,55.58%,and 9.26%,respectively(risk ratio,0.209;95% confidence interval,0.126-0.347;P=0.000).Multivariate analysis revealed that the independent risk factors were therapy mode(P=0.000),sex(P=0.005),family history(P=0.011),TNM Classification of Malignant Tumor staging(P=0.000),medical care-seeking behavior(P=0.021),and maximum diameter(P=0.030).CONCLUSION:Long-term oral use of compound RJH tablets may improve OS for small HCC after resection compared with IT.
基金This article was written with support from the European Community＇s Seventh Framework Programme （Grant No. 321400） and the National Natural Science Foundation （Grant No. 71503263）.
文摘Responsible research and innovation （RRI） represents a new evotvtng approach to governing research and innovation that takes into account potential impacts on the environment and society. Most published studies on RRI focus on the social benefits of research and innovation through examining RRI＇s definitions and approaches for its implementation. In contrast, the present study addresses the influence of RRI on economic growth, and discusses the situations in which RRI will benefit economies. Our study finds that for its implementation to be successful RRI needs to meet certain conditions, and that its implementation is not always beneficial to economic growth. To achieve a better result from RRI as part of an innovation policy, each country should balance the push and pull power of RRI to make sure that it becomes a building block rather than a stumbling block for innovation, economic growth and social welfare. To assure that RRI can be successfully implemented, China needs to strengthen and improve the participation mechanisms for stakeholders in major scientific and technological innovative activities.
