The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for...The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).展开更多
For a nation, culture is not only the promotion and enhancement to the national spirit and the realm of life, but also an essential content and indispensable support force to achieve economic development, it is the im...For a nation, culture is not only the promotion and enhancement to the national spirit and the realm of life, but also an essential content and indispensable support force to achieve economic development, it is the important cause and prominent of the overall strength and the main carrier and specific embodiment of a nation＇s ＂soft power＂, besides, it also represents the degree of civilization, level of development and height of this nation. Culture and cultural industry endow with the modern culture with new meaning, it requires that at the time we achieve the prosperity and development of culture, we must actively explore and operate a scientific mechanism which is most able to release the energy of the culture and play cultural efficiency, and then develop the industrial pathway of the cultural. Cultural industry is a little different from the general industry. This causes the special natm-e of the cultural industry which is different from other industries. Different water and soil raised different people, inheriting national culture and developing cultural industry can be described as the unity of the three ones.展开更多
From the aspect of administrative law to analyze the needs of the ＂public interest＂, evaluate the study of traditional administrative law definition of ＂public interest＂ extensive oversight and administrative miss...From the aspect of administrative law to analyze the needs of the ＂public interest＂, evaluate the study of traditional administrative law definition of ＂public interest＂ extensive oversight and administrative mission and different levels of resistance, from the perspective of administrative policy on science policy the role of the administrative process of the formation of the special nature of administrative law, reflecting the interests of the mechanism of the modem state, the role of public opinion and how to grasp the meaning of the people said that other issues were discussed, in order to reveal the modem administrative law, research must pay attention to the value and benefits of diversification, the complexity of the method.展开更多
文摘The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).
文摘For a nation, culture is not only the promotion and enhancement to the national spirit and the realm of life, but also an essential content and indispensable support force to achieve economic development, it is the important cause and prominent of the overall strength and the main carrier and specific embodiment of a nation＇s ＂soft power＂, besides, it also represents the degree of civilization, level of development and height of this nation. Culture and cultural industry endow with the modern culture with new meaning, it requires that at the time we achieve the prosperity and development of culture, we must actively explore and operate a scientific mechanism which is most able to release the energy of the culture and play cultural efficiency, and then develop the industrial pathway of the cultural. Cultural industry is a little different from the general industry. This causes the special natm-e of the cultural industry which is different from other industries. Different water and soil raised different people, inheriting national culture and developing cultural industry can be described as the unity of the three ones.
文摘From the aspect of administrative law to analyze the needs of the ＂public interest＂, evaluate the study of traditional administrative law definition of ＂public interest＂ extensive oversight and administrative mission and different levels of resistance, from the perspective of administrative policy on science policy the role of the administrative process of the formation of the special nature of administrative law, reflecting the interests of the mechanism of the modem state, the role of public opinion and how to grasp the meaning of the people said that other issues were discussed, in order to reveal the modem administrative law, research must pay attention to the value and benefits of diversification, the complexity of the method.
