Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein...Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein-Barr Virus (EBV) at some extracutaneous sites is well documented. In contrast, the presence of EBV in LELCs has never been shown in either Caucasians or Asian patients. We present the first case of LELCs in a Tunisian patient, a 78-year-old woman who presented with a nodule of the right cheek of 2 months’duration. The patient underwent surgical excision and there was no evidence of local recurrence 6 months later. Histologically, the entire dermis was occupied by lobules composed of atypical epithelial cells surrounded by a dense lymphoplasmacytic infiltrate. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. In situ hybridization investigations for the presence of EBV-encoded RNA showed negative results. Our findings suggest that LELCs is not related to EBV among North African patients.展开更多
突尼斯国立农学院(Istitut National A-gronomique de Tunis简称INAT)1898年1月法国人创办,是一所培养农业工程师的学校,受农业部和教育科学部领导。该院共有110名教员(其中教授30多名),20多名外国教师和30多名外国技术人员,400名职工;...突尼斯国立农学院(Istitut National A-gronomique de Tunis简称INAT)1898年1月法国人创办,是一所培养农业工程师的学校,受农业部和教育科学部领导。该院共有110名教员(其中教授30多名),20多名外国教师和30多名外国技术人员,400名职工;现有514名学生,博士和硕士生占23％。已培养2000多名农业工程师,其中突尼斯人925人、77％在农业部各司局、教学科研单位和生产组织工作。该院学制四年,本科生入学后第一年读预备班,通过后,学专业(农学、种植、土壤学、耕地保护、园艺、动物生产科学。展开更多
文摘Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein-Barr Virus (EBV) at some extracutaneous sites is well documented. In contrast, the presence of EBV in LELCs has never been shown in either Caucasians or Asian patients. We present the first case of LELCs in a Tunisian patient, a 78-year-old woman who presented with a nodule of the right cheek of 2 months’duration. The patient underwent surgical excision and there was no evidence of local recurrence 6 months later. Histologically, the entire dermis was occupied by lobules composed of atypical epithelial cells surrounded by a dense lymphoplasmacytic infiltrate. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. In situ hybridization investigations for the presence of EBV-encoded RNA showed negative results. Our findings suggest that LELCs is not related to EBV among North African patients.
文摘突尼斯国立农学院(Istitut National A-gronomique de Tunis简称INAT)1898年1月法国人创办,是一所培养农业工程师的学校,受农业部和教育科学部领导。该院共有110名教员(其中教授30多名),20多名外国教师和30多名外国技术人员,400名职工;现有514名学生,博士和硕士生占23％。已培养2000多名农业工程师,其中突尼斯人925人、77％在农业部各司局、教学科研单位和生产组织工作。该院学制四年,本科生入学后第一年读预备班,通过后,学专业(农学、种植、土壤学、耕地保护、园艺、动物生产科学。
