Gliomatosis Cerebri （GC） is a rare tumor of the central nervous system. It is defined as a diffuse glial tumor that extensively infiltrates the brain, involving more than two lobes. And it is listed as a subtype of ...Gliomatosis Cerebri （GC） is a rare tumor of the central nervous system. It is defined as a diffuse glial tumor that extensively infiltrates the brain, involving more than two lobes. And it is listed as a subtype of astrocytic tumors according to the newest 2007 （4th edition） WHO classification of tumors of the Central Nervous System. GC can be subdivided into Type I and Type II. Clinical findings for patients with GC are usually subtle and nonspecific. The lesions of GC generally show hypo, or isodensity on CT; a poorly defined diffuse hypoor isointense signal on Tl-weighted images, and a scattered diffuse hyperintense signal on T2-weighted images. Histological examination of GC reveals widespread infiltration of neoplastic glial cells with minimal destruction of pre-existing structures. Diagnosis of GC can be ascertained on the basis of a combination of clinical, radiological and pathological data. The treatment of GC includes radiotherapy and chemotherapy; however, the optimal therapeutic strategy is still not well established and prognosis of GC remains poor. This report reviews in detail the aspects of GC mentioned above, and three controversial issues are also discussed in the report.展开更多
Objective:To explore the mechanism of Xiaotan Sanjie Recipe (XtSjR, Recipe for dissolving phlegm to eliminate stagnation) in inhibiting proliferation of gastric cancer cells. Methods: The nude mouse human gastric canc...Objective:To explore the mechanism of Xiaotan Sanjie Recipe (XtSjR, Recipe for dissolving phlegm to eliminate stagnation) in inhibiting proliferation of gastric cancer cells. Methods: The nude mouse human gastric cancer MKN-45 in situ transplantation tumor model was established by use of OB glue, and 40 model mice were randomized into 5 groups, model group, low-dose XtSjR group, middle-dose XtSjR group, high-dose XtSjR group, and 5-Fu group, 8 rats in each group. Human gastric cancer MKN-45 telomerase reverse transcriptase (hTERT) protein and mRNA expressions were assayed by immunohistochemical method and real-time fluorescence quantitative RT-PCR, and influences of XtSjR on the expressions of hTERT protein and mRNA were investigated in the nude mouse human gastric cancer MKN-45 in situ tumor transplantation model. Results: 1) There were significant differences in the mean tumor weight between the low-, middle-, high-dose XtSjR groups and the model group (all P<0.01); 2) There were significant differences in the hTERT positive expression rate between the middle-and high-dose XtSjR groups and the model group (P<0.05 or P<0.01); 3) There were significant differences in the hTERT mRNA content between the middle-and high-dose XtSjR groups and the model group (P<0.05 or P<0.01). Conclusion: 1) XtSjR has a marked inhibitory effect on the growth of gastric cancer cells; 2) XtSjR inhibits telomerase activity by down-regulating the expressions of hTERT protein and mRNA, shortening the length of cancer cell telomeres gradually, losing the ability to infinitely proliferate, and finally inhibiting the growth and proliferation of tumor cells.展开更多
Anticipated backward stochastic differential equations, studied the first time in 2007, are equations of the following type:{-dY t = f(t1, Y t1 , Z t1 , Y t+δ(t) , Z t+ζ(t) )dt Z t dB t1 , t ∈ [0, T ], Y t = ξ t1 ...Anticipated backward stochastic differential equations, studied the first time in 2007, are equations of the following type:{-dY t = f(t1, Y t1 , Z t1 , Y t+δ(t) , Z t+ζ(t) )dt Z t dB t1 , t ∈ [0, T ], Y t = ξ t1 , t ∈ [T, T + K], Z t = η t1 , t ∈ [T, T + K].In this paper, we give a necessary and sufficient condition under which the comparison theorem holds for multidimensional anticipated backward stochastic differential equations with generators independent of the anticipated term of Z.展开更多
基金supported by grants from National Science Foundation of China(No.30672159)New Century Excellent Talents of Chinese Universities(No.NCET-06-0306)
文摘Gliomatosis Cerebri （GC） is a rare tumor of the central nervous system. It is defined as a diffuse glial tumor that extensively infiltrates the brain, involving more than two lobes. And it is listed as a subtype of astrocytic tumors according to the newest 2007 （4th edition） WHO classification of tumors of the Central Nervous System. GC can be subdivided into Type I and Type II. Clinical findings for patients with GC are usually subtle and nonspecific. The lesions of GC generally show hypo, or isodensity on CT; a poorly defined diffuse hypoor isointense signal on Tl-weighted images, and a scattered diffuse hyperintense signal on T2-weighted images. Histological examination of GC reveals widespread infiltration of neoplastic glial cells with minimal destruction of pre-existing structures. Diagnosis of GC can be ascertained on the basis of a combination of clinical, radiological and pathological data. The treatment of GC includes radiotherapy and chemotherapy; however, the optimal therapeutic strategy is still not well established and prognosis of GC remains poor. This report reviews in detail the aspects of GC mentioned above, and three controversial issues are also discussed in the report.
基金supported by a grant from the Postdoctoral fund of China (20060400639)
文摘Objective:To explore the mechanism of Xiaotan Sanjie Recipe (XtSjR, Recipe for dissolving phlegm to eliminate stagnation) in inhibiting proliferation of gastric cancer cells. Methods: The nude mouse human gastric cancer MKN-45 in situ transplantation tumor model was established by use of OB glue, and 40 model mice were randomized into 5 groups, model group, low-dose XtSjR group, middle-dose XtSjR group, high-dose XtSjR group, and 5-Fu group, 8 rats in each group. Human gastric cancer MKN-45 telomerase reverse transcriptase (hTERT) protein and mRNA expressions were assayed by immunohistochemical method and real-time fluorescence quantitative RT-PCR, and influences of XtSjR on the expressions of hTERT protein and mRNA were investigated in the nude mouse human gastric cancer MKN-45 in situ tumor transplantation model. Results: 1) There were significant differences in the mean tumor weight between the low-, middle-, high-dose XtSjR groups and the model group (all P<0.01); 2) There were significant differences in the hTERT positive expression rate between the middle-and high-dose XtSjR groups and the model group (P<0.05 or P<0.01); 3) There were significant differences in the hTERT mRNA content between the middle-and high-dose XtSjR groups and the model group (P<0.05 or P<0.01). Conclusion: 1) XtSjR has a marked inhibitory effect on the growth of gastric cancer cells; 2) XtSjR inhibits telomerase activity by down-regulating the expressions of hTERT protein and mRNA, shortening the length of cancer cell telomeres gradually, losing the ability to infinitely proliferate, and finally inhibiting the growth and proliferation of tumor cells.
文摘Anticipated backward stochastic differential equations, studied the first time in 2007, are equations of the following type:{-dY t = f(t1, Y t1 , Z t1 , Y t+δ(t) , Z t+ζ(t) )dt Z t dB t1 , t ∈ [0, T ], Y t = ξ t1 , t ∈ [T, T + K], Z t = η t1 , t ∈ [T, T + K].In this paper, we give a necessary and sufficient condition under which the comparison theorem holds for multidimensional anticipated backward stochastic differential equations with generators independent of the anticipated term of Z.
