A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoi...A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano’s classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow- up EGD and histological examinations detected no recurrence of the disease.展开更多
In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of ga...In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of gastric perforation due to the high acidic gastric juice and violent deformation of the gastric wall.Regarding these challenges,we proposed an ionic nano-reservoir(INR)-based dual-network hydrogel,which has excellent adhesion and mechanical properties,and can be easily applied to the perforation site to block the perforation while promoting tissue repairing.The results showed that the first network made of polyacrylamide had cross-linked on the stomach tissue within 5 s under blue light,and enhanced the adhesion performance through mechanical interlock.The nano-hydroxyapatite acted as ionic INR,which can gradually release Ca^(2+) under acid environments to form the second network with sodium alginate and inhibit the swelling of hydrogel in gastric juice.Meanwhile,the adhesion was further enhanced through amide covalent bonds at the hydrogel-tissue interface with the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide(EDC/NHS).The dual network hydrogels obtained by the INR strategy could be employed as a potential therapeutic option for gastric perforation and other similar biomedical prolems.展开更多
基金Supported in part by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture in Japan
文摘A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano’s classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow- up EGD and histological examinations detected no recurrence of the disease.
基金supported by the National Natural Science Foundation of China(81971701,51832001,and 81901873)the Natural Science Foundation of Jiangsu Province(BK20201352)the Program of Jiangsu Specially-Appointed Professor。
文摘In recent years,remarkable progress has been made in the research of injectable hydrogel for internal tissue healing.However,the therapeutic outcome is usually limited when the hydrogel is used for the treatment of gastric perforation due to the high acidic gastric juice and violent deformation of the gastric wall.Regarding these challenges,we proposed an ionic nano-reservoir(INR)-based dual-network hydrogel,which has excellent adhesion and mechanical properties,and can be easily applied to the perforation site to block the perforation while promoting tissue repairing.The results showed that the first network made of polyacrylamide had cross-linked on the stomach tissue within 5 s under blue light,and enhanced the adhesion performance through mechanical interlock.The nano-hydroxyapatite acted as ionic INR,which can gradually release Ca^(2+) under acid environments to form the second network with sodium alginate and inhibit the swelling of hydrogel in gastric juice.Meanwhile,the adhesion was further enhanced through amide covalent bonds at the hydrogel-tissue interface with the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide(EDC/NHS).The dual network hydrogels obtained by the INR strategy could be employed as a potential therapeutic option for gastric perforation and other similar biomedical prolems.
