Objective: To investigate the expression of CD28 and CTLA- 4, two costimulatory molecules involved in T-cell activation at the maternal-fetal interface in women with unexplained pregnancy loss. Methods: A total of 57 ...Objective: To investigate the expression of CD28 and CTLA- 4, two costimulatory molecules involved in T-cell activation at the maternal-fetal interface in women with unexplained pregnancy loss. Methods: A total of 57 women, 39 with unexplained spontaneous abortion (SA) and 18 with unexplained recurrent spontaneous abortion (RSA), were enrolled in the study. A high-resolution spectratyping analysis of fluorescent bands was performed to detect CD28 and CTLA- 4 expression in decidual tissues. Results: The mean expression of CTLA-4 mRNA was significantly higher in women with SA than in controls (P < 0.05). Moreover, the expression of CTLA-4 was higher in SA patients with genotype AA and phenotype A+ (AA + AG) than in controls (P < 0.01). The expression of CTLA-4 was not significantly different in patients with RSA and in controls. The expression of CD28 was significantly decreased in patients with RSA (P < 0.01) and SA (P < 0.05) compared with controls. The mean ratios of CTLA-4/CD28 were significantly higher in patients with RSA (P < 0.01) and SA (P < 0.05) than in controls. Conclusions: This study suggests that an imbalance in CTLA-4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss.展开更多
细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocyte associated antigen-4,CTLA-4)是一种跨膜蛋白质,能够抑制T细胞的增殖与活化,降低机体抗肿瘤免疫反应。CTLA-4与多种肿瘤的形成相关,其与肺癌的内在联系也备受关注。同时在肺癌的免...细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocyte associated antigen-4,CTLA-4)是一种跨膜蛋白质,能够抑制T细胞的增殖与活化,降低机体抗肿瘤免疫反应。CTLA-4与多种肿瘤的形成相关,其与肺癌的内在联系也备受关注。同时在肺癌的免疫治疗中CTLA-4也扮演着重要的角色。本文就近年来CTLA-4与肺癌的研究进展进行综述。展开更多
文摘Objective: To investigate the expression of CD28 and CTLA- 4, two costimulatory molecules involved in T-cell activation at the maternal-fetal interface in women with unexplained pregnancy loss. Methods: A total of 57 women, 39 with unexplained spontaneous abortion (SA) and 18 with unexplained recurrent spontaneous abortion (RSA), were enrolled in the study. A high-resolution spectratyping analysis of fluorescent bands was performed to detect CD28 and CTLA- 4 expression in decidual tissues. Results: The mean expression of CTLA-4 mRNA was significantly higher in women with SA than in controls (P < 0.05). Moreover, the expression of CTLA-4 was higher in SA patients with genotype AA and phenotype A+ (AA + AG) than in controls (P < 0.01). The expression of CTLA-4 was not significantly different in patients with RSA and in controls. The expression of CD28 was significantly decreased in patients with RSA (P < 0.01) and SA (P < 0.05) compared with controls. The mean ratios of CTLA-4/CD28 were significantly higher in patients with RSA (P < 0.01) and SA (P < 0.05) than in controls. Conclusions: This study suggests that an imbalance in CTLA-4/CD28 expression or suppressed T-cell activity at the maternal-fetal interface may confer susceptibility to unexplained pregnancy loss.
文摘细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocyte associated antigen-4,CTLA-4)是一种跨膜蛋白质,能够抑制T细胞的增殖与活化,降低机体抗肿瘤免疫反应。CTLA-4与多种肿瘤的形成相关,其与肺癌的内在联系也备受关注。同时在肺癌的免疫治疗中CTLA-4也扮演着重要的角色。本文就近年来CTLA-4与肺癌的研究进展进行综述。
