The study showed that freezing-thawing method could have a higher cellwall breakage rate,and a light injury to the active substance,which could not only increase the cell fission and growth,delay the death of Saccharo...The study showed that freezing-thawing method could have a higher cellwall breakage rate,and a light injury to the active substance,which could not only increase the cell fission and growth,delay the death of Saccharomycete cells,but also enhance CO2 production rate and quicken fermentation process when the cells were exposed to the medium with 0.5% active substance.展开更多
Neopterin is bioactive substance released by the activated monocyte/macrophage, and an early and sensitive marker used for reflection of cellular immune activation status induced by the lymphocyte macrophage system. O...Neopterin is bioactive substance released by the activated monocyte/macrophage, and an early and sensitive marker used for reflection of cellular immune activation status induced by the lymphocyte macrophage system. Observation of neopterin levels is conducive to the diagnosis and prognosis of various diseases. This article reviews the existing evidence that neopterin has an important role in cardiovascular risk, infectious diseases, malignancy, autoimmune diseases and transplantaiton.展开更多
Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochond...Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochondria-targeting agent, exhibits potential therapeutic effects for tumors. Based on the effects of DCA on tumor cellular metabolism, we carried out this study to investigate the anti-tumor activity of DCA in C6 glioma cells in vitro. The results showed that DCA was able to increase the activity of pyruvate dehydrogenase （PDH）, induce the production of reactive oxygen species （ROS） and reduce the mitochondrial membrane potential （MMP） in C6 ceils in vitro （P〈0.05 or 0.01）, indicating that the anti-tumor effects of DCA in C6 cells could be through the activation of the mitochondrial pathway. In conclusion, mitochondria could be a viable therapeutic target for the treatment of glioma.展开更多
文摘The study showed that freezing-thawing method could have a higher cellwall breakage rate,and a light injury to the active substance,which could not only increase the cell fission and growth,delay the death of Saccharomycete cells,but also enhance CO2 production rate and quicken fermentation process when the cells were exposed to the medium with 0.5% active substance.
文摘Neopterin is bioactive substance released by the activated monocyte/macrophage, and an early and sensitive marker used for reflection of cellular immune activation status induced by the lymphocyte macrophage system. Observation of neopterin levels is conducive to the diagnosis and prognosis of various diseases. This article reviews the existing evidence that neopterin has an important role in cardiovascular risk, infectious diseases, malignancy, autoimmune diseases and transplantaiton.
基金National Natural Science Foundation of China (Grant No.30873170)the National Basic Research Program of China(973 Program 2007CB935800 and 2009CB930300)
文摘Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochondria-targeting agent, exhibits potential therapeutic effects for tumors. Based on the effects of DCA on tumor cellular metabolism, we carried out this study to investigate the anti-tumor activity of DCA in C6 glioma cells in vitro. The results showed that DCA was able to increase the activity of pyruvate dehydrogenase （PDH）, induce the production of reactive oxygen species （ROS） and reduce the mitochondrial membrane potential （MMP） in C6 ceils in vitro （P〈0.05 or 0.01）, indicating that the anti-tumor effects of DCA in C6 cells could be through the activation of the mitochondrial pathway. In conclusion, mitochondria could be a viable therapeutic target for the treatment of glioma.
