目的探讨超声引导细针穿刺活检技术鉴别诊断甲状腺影像报告与数据系统(thyroid imaging reporting and data system,TI-RADS)4类甲状腺结节良恶性的临床价值。方法选择2021年3月—2022年6月赣州市赣县区人民医院收治的TI-RADS 4类甲状...目的探讨超声引导细针穿刺活检技术鉴别诊断甲状腺影像报告与数据系统(thyroid imaging reporting and data system,TI-RADS)4类甲状腺结节良恶性的临床价值。方法选择2021年3月—2022年6月赣州市赣县区人民医院收治的TI-RADS 4类甲状腺结节患者50例(共72个结节),所有患者均行超声引导细针穿刺活检技术检查,并与术后病理结果进行比较,分析超声引导细针穿刺活检技术鉴别诊断TI-RADS 4类甲状腺结节良恶性的效能。结果术后病理检查结果显示,良性结节40个,包括乳头型腺瘤、滤泡型腺瘤、结节性甲状腺肿、亚急性甲状腺炎、桥本甲状腺炎结节;恶性结节32个,包括乳头状癌、滤泡性癌、未分化癌、髓样癌。纳入研究的72个可疑甲状腺结节中,超声引导细针穿刺活检呈恶性的结节31个、良性41个,TI-RADS 4a、4b、4c类Kappa值分别为0.862、0.768、0.821,均>0.75,超声引导细针穿刺活检技术与术后病理结果具有较好的一致性。超声引导细针穿刺活检技术鉴别诊断TI-RADS 4类甲状腺结节良恶性的特异度、灵敏度、准确度、阳性预测值、阴性预测值分别为90.00%、84.38%、87.50%、87.10%、87.80%。结论应用超声引导细针穿刺活检技术鉴别诊断TI-RADS 4类甲状腺结节的良恶性性质具有较好的临床诊断意义,能够提高临床诊断灵敏度与准确率。展开更多
目的:探究甲状腺癌的临床病理特点及细针穿刺活检技术。方法:选取2023年1月到2024年6月我院100例甲状腺癌患者,术前全部接受细针穿刺活检技术检查,然后予以手术病理检查,对比两种诊断方式的结果。结果:所有患者中,以女性为主,≥45岁以...目的:探究甲状腺癌的临床病理特点及细针穿刺活检技术。方法:选取2023年1月到2024年6月我院100例甲状腺癌患者,术前全部接受细针穿刺活检技术检查,然后予以手术病理检查,对比两种诊断方式的结果。结果:所有患者中,以女性为主,≥45岁以上为高发年龄段,城市发病群体更多。疾病类型中,以乳头状甲状腺癌为主。多数患者的肿瘤直径一般在1 cm及以下,病灶往往为多个。两种诊断方式下的疾病检出率均较高,差异无统计学意义(P > 0.05)。结论:细针穿刺活检技术检查具有一定意义,疾病检出率高,且其结果能够反应疾病的病理特点,可为医生的诊治提供科学参考。Objective: To investigate the clinicopathologic features and fine needle aspiration biopsy technique of the thyroid cancer. Methods: A total of 100 patients with thyroid cancer from January 2023 to June 2024 in our hospital were examined by fine needle aspiration biopsy before operation, and then underwent surgical pathological examination. Compare the results of the two diagnostic methods. Results: Most of the patients were female, over 45 years old was the high incidence age group, and more patients were found in urban area. Most of the diseases are papillary thyroid cancer. In most patients, the diameter of the tumor is usually less than 1 cm and the lesions are usually multiple. There was no significant difference between the two diagnostic methods (P > 0.05). Conclusion: The fine needle aspiration biopsy technique has certain significance, the disease detection rate is high, and its results can reflect the pathological characteristics of the disease, and can provide scientific reference for doctors’ diagnosis and treatment.展开更多
目的:探讨BRAF V600E基因检测在诊断意义不明确的细胞非典型病变或滤泡性病变(atypia of undetermined significance or follicular lesion of undetermined significance,AUS/FLUS)结节良恶性中的临床应用价值。方法:回顾并分析南京医...目的:探讨BRAF V600E基因检测在诊断意义不明确的细胞非典型病变或滤泡性病变(atypia of undetermined significance or follicular lesion of undetermined significance,AUS/FLUS)结节良恶性中的临床应用价值。方法:回顾并分析南京医科大学附属南京医院(南京市第一医院)2019年3月—2022年10月术前经超声引导下细针穿刺活检(fine-needle aspiration biopsy,FNAB)诊断为AUS/FLUS,有完整超声评估报告、BRAF V600E检测结果的患者共96例,97个结节,以术后病理学检查为金标准,运用统计学方法研究BRAF V600E基因检测对诊断AUS/FLUS结节良恶性的应用价值。结果:97个AUS/FLUS结节的术后组织学病理中,良性11个,恶性86个,BRAF V600E基因突变71个,且病理学类型均为甲状腺乳头状癌(papillary carcinoma of the thyroid,PTC)。BRAF V600E基因检测诊断AUS/FLUS结节良恶性的灵敏度、特异度、准确度分别为82.6%、100.0%、84.5%。通过计算受试者工作特征(receiver operating characteristic,ROC)曲线的曲线下面积(area under the curve,AUC),证实BRAF V600E基因检测对AUS/FLUS结节的良恶性有较高的诊断价值。BRAF V600E基因突变可以提高AUS/FLUS结节的恶性检出率(P<0.05)。结论:BRAF V600E基因检测对AUS/FLUS结节良恶性具有较高的诊断价值,联合FNAB可提高AUS/FLUS结节的恶性检出率,对临床制订治疗方案有很大帮助。展开更多
文摘目的:探究甲状腺癌的临床病理特点及细针穿刺活检技术。方法:选取2023年1月到2024年6月我院100例甲状腺癌患者,术前全部接受细针穿刺活检技术检查,然后予以手术病理检查,对比两种诊断方式的结果。结果:所有患者中,以女性为主,≥45岁以上为高发年龄段,城市发病群体更多。疾病类型中,以乳头状甲状腺癌为主。多数患者的肿瘤直径一般在1 cm及以下,病灶往往为多个。两种诊断方式下的疾病检出率均较高,差异无统计学意义(P > 0.05)。结论:细针穿刺活检技术检查具有一定意义,疾病检出率高,且其结果能够反应疾病的病理特点,可为医生的诊治提供科学参考。Objective: To investigate the clinicopathologic features and fine needle aspiration biopsy technique of the thyroid cancer. Methods: A total of 100 patients with thyroid cancer from January 2023 to June 2024 in our hospital were examined by fine needle aspiration biopsy before operation, and then underwent surgical pathological examination. Compare the results of the two diagnostic methods. Results: Most of the patients were female, over 45 years old was the high incidence age group, and more patients were found in urban area. Most of the diseases are papillary thyroid cancer. In most patients, the diameter of the tumor is usually less than 1 cm and the lesions are usually multiple. There was no significant difference between the two diagnostic methods (P > 0.05). Conclusion: The fine needle aspiration biopsy technique has certain significance, the disease detection rate is high, and its results can reflect the pathological characteristics of the disease, and can provide scientific reference for doctors’ diagnosis and treatment.
文摘目的:探讨BRAF V600E基因检测在诊断意义不明确的细胞非典型病变或滤泡性病变(atypia of undetermined significance or follicular lesion of undetermined significance,AUS/FLUS)结节良恶性中的临床应用价值。方法:回顾并分析南京医科大学附属南京医院(南京市第一医院)2019年3月—2022年10月术前经超声引导下细针穿刺活检(fine-needle aspiration biopsy,FNAB)诊断为AUS/FLUS,有完整超声评估报告、BRAF V600E检测结果的患者共96例,97个结节,以术后病理学检查为金标准,运用统计学方法研究BRAF V600E基因检测对诊断AUS/FLUS结节良恶性的应用价值。结果:97个AUS/FLUS结节的术后组织学病理中,良性11个,恶性86个,BRAF V600E基因突变71个,且病理学类型均为甲状腺乳头状癌(papillary carcinoma of the thyroid,PTC)。BRAF V600E基因检测诊断AUS/FLUS结节良恶性的灵敏度、特异度、准确度分别为82.6%、100.0%、84.5%。通过计算受试者工作特征(receiver operating characteristic,ROC)曲线的曲线下面积(area under the curve,AUC),证实BRAF V600E基因检测对AUS/FLUS结节的良恶性有较高的诊断价值。BRAF V600E基因突变可以提高AUS/FLUS结节的恶性检出率(P<0.05)。结论:BRAF V600E基因检测对AUS/FLUS结节良恶性具有较高的诊断价值,联合FNAB可提高AUS/FLUS结节的恶性检出率,对临床制订治疗方案有很大帮助。
