结肠管腔中心线的提取在结肠疾病的计算机辅助检测中起到重要的作用,对中心线提取结果的定量评价一直是辅助检测中的难点。从中心线参数方程和截面方程两方面考虑,生成了20套仿真数据,模拟了结肠高曲率、褶皱和管腔的形态特点,提出了一...结肠管腔中心线的提取在结肠疾病的计算机辅助检测中起到重要的作用,对中心线提取结果的定量评价一直是辅助检测中的难点。从中心线参数方程和截面方程两方面考虑,生成了20套仿真数据,模拟了结肠高曲率、褶皱和管腔的形态特点,提出了一系列评价准则。还对最小路径(DIJ)和最大生成树(MST)算法及作者提出的基于生成树的中心线快速提取算法(Fast centerline extraction algorithm based on Maximal Spanning Tree,简称FMST)进行了性能比较。实验结果验证了最大生成树算法解决了中心线在高曲率的拐角问题,保持中心线提取准确率同时,提取速度平均提高80%以上,是三种算法中性能最好的。展开更多
Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with t...Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.展开更多
Objective To observe the influence of Shenqing Recipe (SQR), a kind of Traditional Chinese Medicine, on the morphology and quantity of colonic interstitial ceils of Cajal (ICC) in trinitrobenzene sulfonic acid (TNBS)-...Objective To observe the influence of Shenqing Recipe (SQR), a kind of Traditional Chinese Medicine, on the morphology and quantity of colonic interstitial ceils of Cajal (ICC) in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis, and to investigate the possible mechanism of SQR in regulating intestinal dynamics. Methods Sixty rats were randomly divided into normal control, model Ⅰ , model Ⅱ, mesalazine, and high-dose, and low-dose SQR groups with 10 rats in each group. TNBS (10 mg) dissolved in 50% ethanol was instilled into the lumen of the rat colon of the latter five groups to induce colitis. On the 4th day after administration of TNBS, each treatment group was administered one of the following formulations by enteroclysis gavage once a day for 7 days: 600 mg·kg^-1·d^-1 mesalazine, 2.4g^-1·d^-1 SQR, and 1.2g^-1·d^-1 SQR. Model Ⅱ rats received normal saline solution. After 7 days colonic samples were collected. While the colonic samples of model I group were collected on the 3rd day after TNBS administered. Ultrastructure of ICC in the damaged colonic tissues was observed with transmission electron microscope. Expression of c-kit protein in colonic tissue was determined by immunohistochemical staining and Western blot. Results The ultrastructure of colonic ICC in the rat model of TNBS-induced colitis showed a severe injury, and administration of SQR or mesalazine reduced the severity of injury. Similarly, the expression of c-kit protein of TNBS-induced colitis rat model was significantly decreased compared with the normal control group (P〈0.05). Treatment with SQR or mesalazine significantly increased the expression of c-kit protein compared with the administration of control formulations (P〈0.05), especially the high-dose SQR group. Conclusion SQR could alleviate and repair the injured ICC, and improve its quantity, which might be involved in regulating intestinal motility.展开更多
文摘结肠管腔中心线的提取在结肠疾病的计算机辅助检测中起到重要的作用,对中心线提取结果的定量评价一直是辅助检测中的难点。从中心线参数方程和截面方程两方面考虑,生成了20套仿真数据,模拟了结肠高曲率、褶皱和管腔的形态特点,提出了一系列评价准则。还对最小路径(DIJ)和最大生成树(MST)算法及作者提出的基于生成树的中心线快速提取算法(Fast centerline extraction algorithm based on Maximal Spanning Tree,简称FMST)进行了性能比较。实验结果验证了最大生成树算法解决了中心线在高曲率的拐角问题,保持中心线提取准确率同时,提取速度平均提高80%以上,是三种算法中性能最好的。
基金Supported by A grant from the Ministero della Salute, Rome, within the framework of the Progetto Integrato Oncologia-Advanced Molecular Diagnostics "Multidimensional characterization of solid tumors" and Lega Italiana per la Lotta Contro i Tumori, sezione Milanese
文摘Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.
基金Supported by the Shanghai Committee of Science and Technology Foundation for Research Discipline Project (06411941)the Shanghai Leading Academic Discipline Project (J50305)
文摘Objective To observe the influence of Shenqing Recipe (SQR), a kind of Traditional Chinese Medicine, on the morphology and quantity of colonic interstitial ceils of Cajal (ICC) in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis, and to investigate the possible mechanism of SQR in regulating intestinal dynamics. Methods Sixty rats were randomly divided into normal control, model Ⅰ , model Ⅱ, mesalazine, and high-dose, and low-dose SQR groups with 10 rats in each group. TNBS (10 mg) dissolved in 50% ethanol was instilled into the lumen of the rat colon of the latter five groups to induce colitis. On the 4th day after administration of TNBS, each treatment group was administered one of the following formulations by enteroclysis gavage once a day for 7 days: 600 mg·kg^-1·d^-1 mesalazine, 2.4g^-1·d^-1 SQR, and 1.2g^-1·d^-1 SQR. Model Ⅱ rats received normal saline solution. After 7 days colonic samples were collected. While the colonic samples of model I group were collected on the 3rd day after TNBS administered. Ultrastructure of ICC in the damaged colonic tissues was observed with transmission electron microscope. Expression of c-kit protein in colonic tissue was determined by immunohistochemical staining and Western blot. Results The ultrastructure of colonic ICC in the rat model of TNBS-induced colitis showed a severe injury, and administration of SQR or mesalazine reduced the severity of injury. Similarly, the expression of c-kit protein of TNBS-induced colitis rat model was significantly decreased compared with the normal control group (P〈0.05). Treatment with SQR or mesalazine significantly increased the expression of c-kit protein compared with the administration of control formulations (P〈0.05), especially the high-dose SQR group. Conclusion SQR could alleviate and repair the injured ICC, and improve its quantity, which might be involved in regulating intestinal motility.
