Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this s...Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this study is to investigate the association of a cytosine-adenine （CA） repeat polymorphism in the fifth intron of the ESR2 gene with PMO in Chinese Han population. The CA repeat polymorphism was genotyped in a case-control study, involving 78 femoral neck PMO patients vs. 122 controls and 108 lumbar spine （L2-4） PMO patients vs. 92 controls. The （CA）n〈22 and （CA）n≥22 alleles were designated short （S） and long （L）, respectively. ESR2 genotype was categorically defined as SS （2 S alleles）, SL （having the mixed S and L alleles）, and LL （2 L alleles）. At both the femoral neck and the L2-4 region, LL genotype and L allele frequencies of the PMO group were significantly higher than those of the control group （P〈0.01）. The subjects with the SL, the LL, and the combined SL and LL genotype had a significant increased risk of PMO when compared with those with the SS genotype （P〈0.05）. After adjustments for age, years since menopause, menopausal age, and body mass index, logistic regression analysis showed that the subjects with the combined SL and LL genotype had increased risk of PMO when compared with those with the SS genotype both at the femoral neck （adjusted OR 4.923, 95% CI 1.986-12.203 , P=0.001） and the L2-4 （adjusted OR 2.267, 95% CI 1.121-4.598, P=0.023）. This extensive association study has identified the ESR2 CA repeat polymorphism to be independently associated with PMO at the femoral neck and the L2-4 in Chinese Han population. The data also suggested that the presence of the L allele may dominantly increase the risk of PMO at the two regions.展开更多
According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by th... According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.……展开更多
Primary osteoporosis, a commonly encountered metabolic bone disease in the postmenopausal women and the aged people, can be classified by modern medicine into postmenopausal osteoporosis (Type I) and senile osteop... Primary osteoporosis, a commonly encountered metabolic bone disease in the postmenopausal women and the aged people, can be classified by modern medicine into postmenopausal osteoporosis (Type I) and senile osteoporosis (Type II). The disease seriously affects health and quality of life of the people as it often cause ostealgia, fracture and the secondary symptoms or diseases. Presently, the pharmacotherapy (including both Chinese herbal drugs and western drugs) remains the first among all other therapeutic methods which are mainly adopted in treatment of the disease at home and abroad. Studies related have been curried out quite early and systematically, and considerable progress has been made, but limit of the pharmacotherapy has also been found. Certain non-drug treatments (such as dietetic therapy, physical exercise, acupuncture and moxibustion, and qigong, especially acupuncture and moxibustion therapy, although with a late start, have been proved effective with satisfactory results. The following is a summary of all the contributions concerned.……展开更多
Osteoporosis is a disease characterized by a low bone mineral density and structural deterioration of bone tissue. Leptin is considered to play a role in the maintenance of energy balance and body weight. Weight and b...Osteoporosis is a disease characterized by a low bone mineral density and structural deterioration of bone tissue. Leptin is considered to play a role in the maintenance of energy balance and body weight. Weight and body mass index are associated with low bone mineral density with high serum leptin concentration in older women. The study is designed to elucidate the impact of age and BMI （Body Mass Index） on osteoporotic patients （Iraqi postmenopausal women） and the functional role of leptin in those patients. A total of 72 patients divided into three groups according to BMI and two groups according to age： BMD （bone mineral density）, T-score and serum leptin concentration increased as BMI increased, while with increased age, BMD and T-score deceased and serum leptin concentration increased. There is a significant difference of BMD and T-score in BMI （25-30） group and BMI （〉 30） group from that in BMI （〈 25） group. In conclusions： Both age and BMI have an impact on osteoporosis although age shows more impact on the severity of the disease than does BMI. Studying the direct impact of leptin on BMD may open the way in using new methods in treating and preventing the osteoporosis in patients with risk factors.展开更多
Objective: To observe the clinical efficacy of acupuncture for post- menopausal osteoporosis (PMOP). Methods: A total of 64 PMOP cases were randomized into an observation group and a control group, 32 cases in each gr...Objective: To observe the clinical efficacy of acupuncture for post- menopausal osteoporosis (PMOP). Methods: A total of 64 PMOP cases were randomized into an observation group and a control group, 32 cases in each group. Acupuncture was employed in the observation group, versus oral Osteoform capsule in the control group. After 3-month treatment, the Bone Density (BD) and Estradiol (E 2 ) were measured respectively before and after treatment, followed by statistical analysis on clinical efficacies in the two groups. Results: The total effective rate of the observation group was 81.3%, showing a statistical difference compared with the control group (P<0.05). After treatment, the BD measurements in all body regions of the observation group were significantly elevated (P<0.05), showing a statistical difference compared with the control group (P<0.05). Also, the E 2 levels in both groups were significantly increased (P<0.01), showing no between-group statistical significance (P>0.05). Conclusion: Acupuncture has exact efficacy for PMOP and is therefore effective for the prevention and treatment of PMOP.展开更多
Objective： To observe the clinical effect of combined acupuncture and medication for osteoporosis in postmenopausal women. Methods： A total of 100 cases with postmenopausal osteoporosis were randomly allocated into ...Objective： To observe the clinical effect of combined acupuncture and medication for osteoporosis in postmenopausal women. Methods： A total of 100 cases with postmenopausal osteoporosis were randomly allocated into a treatment group and a control group, 50 in each group. The cases in the treatment group were treated with electroacupuncture coupled with Calcitriol soft capsules, while the cases in the control group were treated with electroacupuncture alone. Results： There were significant differences in treatment effects between the treatment group and control group （P〈0.05）. Conclusion： Combined acupuncture and medication can obtain a marked effect for postmenopausal osteoporosis.展开更多
文摘Postmenopausal osteoporosis （PMO） is considered a polygenic disease. The estrogen receptor β （ESR2） gene is a candidate mediating the genetic influence on bone mass and the risk of osteoporosis. The aim of this study is to investigate the association of a cytosine-adenine （CA） repeat polymorphism in the fifth intron of the ESR2 gene with PMO in Chinese Han population. The CA repeat polymorphism was genotyped in a case-control study, involving 78 femoral neck PMO patients vs. 122 controls and 108 lumbar spine （L2-4） PMO patients vs. 92 controls. The （CA）n〈22 and （CA）n≥22 alleles were designated short （S） and long （L）, respectively. ESR2 genotype was categorically defined as SS （2 S alleles）, SL （having the mixed S and L alleles）, and LL （2 L alleles）. At both the femoral neck and the L2-4 region, LL genotype and L allele frequencies of the PMO group were significantly higher than those of the control group （P〈0.01）. The subjects with the SL, the LL, and the combined SL and LL genotype had a significant increased risk of PMO when compared with those with the SS genotype （P〈0.05）. After adjustments for age, years since menopause, menopausal age, and body mass index, logistic regression analysis showed that the subjects with the combined SL and LL genotype had increased risk of PMO when compared with those with the SS genotype both at the femoral neck （adjusted OR 4.923, 95% CI 1.986-12.203 , P=0.001） and the L2-4 （adjusted OR 2.267, 95% CI 1.121-4.598, P=0.023）. This extensive association study has identified the ESR2 CA repeat polymorphism to be independently associated with PMO at the femoral neck and the L2-4 in Chinese Han population. The data also suggested that the presence of the L allele may dominantly increase the risk of PMO at the two regions.
文摘 According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.……
文摘 Primary osteoporosis, a commonly encountered metabolic bone disease in the postmenopausal women and the aged people, can be classified by modern medicine into postmenopausal osteoporosis (Type I) and senile osteoporosis (Type II). The disease seriously affects health and quality of life of the people as it often cause ostealgia, fracture and the secondary symptoms or diseases. Presently, the pharmacotherapy (including both Chinese herbal drugs and western drugs) remains the first among all other therapeutic methods which are mainly adopted in treatment of the disease at home and abroad. Studies related have been curried out quite early and systematically, and considerable progress has been made, but limit of the pharmacotherapy has also been found. Certain non-drug treatments (such as dietetic therapy, physical exercise, acupuncture and moxibustion, and qigong, especially acupuncture and moxibustion therapy, although with a late start, have been proved effective with satisfactory results. The following is a summary of all the contributions concerned.……
文摘Osteoporosis is a disease characterized by a low bone mineral density and structural deterioration of bone tissue. Leptin is considered to play a role in the maintenance of energy balance and body weight. Weight and body mass index are associated with low bone mineral density with high serum leptin concentration in older women. The study is designed to elucidate the impact of age and BMI （Body Mass Index） on osteoporotic patients （Iraqi postmenopausal women） and the functional role of leptin in those patients. A total of 72 patients divided into three groups according to BMI and two groups according to age： BMD （bone mineral density）, T-score and serum leptin concentration increased as BMI increased, while with increased age, BMD and T-score deceased and serum leptin concentration increased. There is a significant difference of BMD and T-score in BMI （25-30） group and BMI （〉 30） group from that in BMI （〈 25） group. In conclusions： Both age and BMI have an impact on osteoporosis although age shows more impact on the severity of the disease than does BMI. Studying the direct impact of leptin on BMD may open the way in using new methods in treating and preventing the osteoporosis in patients with risk factors.
基金supported by Changsha Hospital of Traditional Chinese Medicine
文摘Objective: To observe the clinical efficacy of acupuncture for post- menopausal osteoporosis (PMOP). Methods: A total of 64 PMOP cases were randomized into an observation group and a control group, 32 cases in each group. Acupuncture was employed in the observation group, versus oral Osteoform capsule in the control group. After 3-month treatment, the Bone Density (BD) and Estradiol (E 2 ) were measured respectively before and after treatment, followed by statistical analysis on clinical efficacies in the two groups. Results: The total effective rate of the observation group was 81.3%, showing a statistical difference compared with the control group (P<0.05). After treatment, the BD measurements in all body regions of the observation group were significantly elevated (P<0.05), showing a statistical difference compared with the control group (P<0.05). Also, the E 2 levels in both groups were significantly increased (P<0.01), showing no between-group statistical significance (P>0.05). Conclusion: Acupuncture has exact efficacy for PMOP and is therefore effective for the prevention and treatment of PMOP.
基金Science & Technology Planning Project by the Zhejiang Provincial Science and Technology Bureau (2008C30003)
文摘Objective： To observe the clinical effect of combined acupuncture and medication for osteoporosis in postmenopausal women. Methods： A total of 100 cases with postmenopausal osteoporosis were randomly allocated into a treatment group and a control group, 50 in each group. The cases in the treatment group were treated with electroacupuncture coupled with Calcitriol soft capsules, while the cases in the control group were treated with electroacupuncture alone. Results： There were significant differences in treatment effects between the treatment group and control group （P〈0.05）. Conclusion： Combined acupuncture and medication can obtain a marked effect for postmenopausal osteoporosis.
