目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2...目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2022年12月发表文献进行计量学可视化分析,分析内容为发表文章的年度分布、被引情况、关键词的共现、聚类、时间线图和国家、机构、基金等。结果通过对313篇基于NHANES数据库的肝脏疾病领域文献进行可视化分析显示,该领域的发文量呈逐年递增,美国是发文量及中心性居首,伊诺瓦卫生系统为发文量最多的机构,美国卫生部人类服务部是资助该领域最多的基金资助机构,对关键词共现、聚类、时间线图分析提示非酒精性脂肪性肝病、代谢相关脂肪性肝病(MAFLD)、肝纤维化、代谢综合征方面为研究热门。结论代谢性肝病、病毒性肝炎和肝纤维化是肝病的主要研究热点。流行病学调查、危险因素评估和诊断方法是主要的分析方法。营养干预和肝病预防是未来的研究方向。机器学习在数据挖掘中具有广泛的适用性。展开更多
无节制地饮酒（酗酒）在年轻人中流行率最高,然而,酗酒对年龄18～45岁的个体血压和其他心血管健康指标的影响知之甚少。为了确定长期酗酒对血压、血脂和血糖水平的影响,并确定这些关联在男性和女性之间是否存在差异,Piano等分析了来自...无节制地饮酒（酗酒）在年轻人中流行率最高,然而,酗酒对年龄18～45岁的个体血压和其他心血管健康指标的影响知之甚少。为了确定长期酗酒对血压、血脂和血糖水平的影响,并确定这些关联在男性和女性之间是否存在差异,Piano等分析了来自美国国家健康与营养调查（the US national health and nutrition examination survey）的数据.展开更多
Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained ...Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained elevations in ALT and serum leptin in NHANES III participants. Methods: A total of 6343 adults who had fasting serum leptin and ALT measured as part of NHANES III constituted our study group. From this database, we have constructed cohorts of patients with unexplained elevations in ALT according to published criteria and compared their serum leptin levels to matched controls without liver disease and matched controls with hepatitis C. Leptin was also compared between patients with unexplained elevations in ALT with and without metabolic syndrome. Results: Serum leptin in 288 patients with unexplained elevations in ALT was 13.3 ±9.9 ng/mL and was not significantly different than 720 controls without liver disease (13.6 ±11.9 ng/mL, P = 0.6). Serum leptin in another group of patients with unexplained elevations in ALT and hepatitis C controls was also not significantly different (8.0 ±4.8 vs. 8.8 ±7.4 ng/mL, respectively, P = 0.5). There was no independent relationship between the presence of metabolic syndrome and serum leptin in individuals with unexplained elevations in ALT (P = 0.8). Conclusions: Individuals with unexplained elevations in ALT did not have higher levels of serum leptin than the matched controls. As unexplained elevations in ALT may signify the presence of non-alcoholic fatty liver disease in NHANES III participants, our data provide indirect evidence against a role for serum leptin in the pathogenesis of nonalcoholic fatty liver disease.展开更多
文摘目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2022年12月发表文献进行计量学可视化分析,分析内容为发表文章的年度分布、被引情况、关键词的共现、聚类、时间线图和国家、机构、基金等。结果通过对313篇基于NHANES数据库的肝脏疾病领域文献进行可视化分析显示,该领域的发文量呈逐年递增,美国是发文量及中心性居首,伊诺瓦卫生系统为发文量最多的机构,美国卫生部人类服务部是资助该领域最多的基金资助机构,对关键词共现、聚类、时间线图分析提示非酒精性脂肪性肝病、代谢相关脂肪性肝病(MAFLD)、肝纤维化、代谢综合征方面为研究热门。结论代谢性肝病、病毒性肝炎和肝纤维化是肝病的主要研究热点。流行病学调查、危险因素评估和诊断方法是主要的分析方法。营养干预和肝病预防是未来的研究方向。机器学习在数据挖掘中具有广泛的适用性。
文摘无节制地饮酒（酗酒）在年轻人中流行率最高,然而,酗酒对年龄18～45岁的个体血压和其他心血管健康指标的影响知之甚少。为了确定长期酗酒对血压、血脂和血糖水平的影响,并确定这些关联在男性和女性之间是否存在差异,Piano等分析了来自美国国家健康与营养调查（the US national health and nutrition examination survey）的数据.
文摘Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained elevations in ALT and serum leptin in NHANES III participants. Methods: A total of 6343 adults who had fasting serum leptin and ALT measured as part of NHANES III constituted our study group. From this database, we have constructed cohorts of patients with unexplained elevations in ALT according to published criteria and compared their serum leptin levels to matched controls without liver disease and matched controls with hepatitis C. Leptin was also compared between patients with unexplained elevations in ALT with and without metabolic syndrome. Results: Serum leptin in 288 patients with unexplained elevations in ALT was 13.3 ±9.9 ng/mL and was not significantly different than 720 controls without liver disease (13.6 ±11.9 ng/mL, P = 0.6). Serum leptin in another group of patients with unexplained elevations in ALT and hepatitis C controls was also not significantly different (8.0 ±4.8 vs. 8.8 ±7.4 ng/mL, respectively, P = 0.5). There was no independent relationship between the presence of metabolic syndrome and serum leptin in individuals with unexplained elevations in ALT (P = 0.8). Conclusions: Individuals with unexplained elevations in ALT did not have higher levels of serum leptin than the matched controls. As unexplained elevations in ALT may signify the presence of non-alcoholic fatty liver disease in NHANES III participants, our data provide indirect evidence against a role for serum leptin in the pathogenesis of nonalcoholic fatty liver disease.
