Objective: To study the effect of vancomycin (V) with multiple intravenous injections on the inner ear of albino guinea pigs. Methods: Three groups of animals were injected with vancomycin hydrochloride (54, 108, 216 ...Objective: To study the effect of vancomycin (V) with multiple intravenous injections on the inner ear of albino guinea pigs. Methods: Three groups of animals were injected with vancomycin hydrochloride (54, 108, 216 mg/kg respectively once a day for 14 d). Two groups were treated with gentamycin (GM) (80 mg·kg -1 ·d -1 ) and saline respectively as control groups. Auditory brainstem responses (ABR) and the duration of post-rotatory nystagmus (PRN) were measured before and after administration. Surface preparation and scanning electron microscopy (SEM) of the cochlea were performed for histological examination. Results: In V 54, 108 mg/kg group, similar to saline control, there was 0-1.1 dB of threshold shift. In V 216 mg/kg group, average hearing loss was 1.0-5.7 dB immediately after administration and 1.3-3.8 dB after 14 d, which was significantly lower than those in GM control group. As the saline control, no significant difference was found in PRN in all V groups before and after treatment; while in the GM group, PRN decreased significantly after treatment. Morphological evaluation demonstrated that in all V and saline animals there was no obvious missing of outer and inner hair cells and SEM showed normal surface morphology. In the GM group, there was 10%-30% of outer and inner hair cells lost in the basal turn. Conclusion: The ototoxicity of vancomycin is absent or minimal after multiple introvenous administration within this dose range.展开更多
Rockfalls can cause serious damage to people,property,facilities and transportation corridors.Furthermore,rockfalls are major hazards in mountain areas with negative impacts on individual trees and forested ecosystems...Rockfalls can cause serious damage to people,property,facilities and transportation corridors.Furthermore,rockfalls are major hazards in mountain areas with negative impacts on individual trees and forested ecosystems.We conducted a study of rockfall events on 117 mapped(91% of total trees in the stand with>1.3 m in height and>5 cm diameter at breast height)Turkish fir trees(Abies bornmuelleriana Mattf.)in a stand within the Kayaarkasi-Topular Village,Inebolu district, Kastamonu province of Turkey.The study site of 0.35 Ha is located on the transition zone of frequently passing rockfall fragments(～40 cm in diameter) generally causing healable injuries.Parameters of trees and injuries were recorded and analysed as to injury number,height and size.Bivariate correlation analysis were used to investigate the relationships between:a)diameter at breast height and number of injuries per tree,b)diameter at breast height and total injury size,c)the number of injuries and total injury size and d)the number of injuries per tree and distance from the source of the rockfall area.Results indicate that the average height of injury,average number of injuries and average injury area to be 81.3 cm(STDEV:49.8),7.46(STDEV:4.4)and 628.6 cm2 (STDEV:678.2),respectively.In total 84% of all injuries were recorded within 160°sector at the upslope side of trees and callus tissue that had closed wounds was observed in 79.1% of all injuries. Furthermore 14.5% of injured trees had callus tissue in the process of closing wounds while 6.4% of injuries had not formed any callus tissue.The most common injury types were bark and wood injuries. Bivariate correlation analysis indicated strong relationships between diameter at breast height and the number of injuries(rs=0.524),injury number and total injury area(rs=0.653)and distance from rockfall area and injury numbers relations(rs=-0.518).A weaker relationship was found between diameter at breast height and total injury area(rs=0.363).These results indicate that bigger trees are more prone to rockfall injuries.As expected,trees further from the rockfall area seem to be less prone to rockfall injuries.From our results,it can be inferred that the protection of people and property can be increased through the maintanance of forest in areas immediately below areas prone to rockfall.This stand is still managed in selective forest management system.In order to protect the settlement at the deposition zone it has to manage for protective goals with uneven-aged and multilayered stand structure.展开更多
Objective:: To explore the characteristics and treatment of temporal bone fractures and injuries in the medial-inner ear. Methods: The clinical data of 48 cases of temporal bone fractures admitted to our hospital from...Objective:: To explore the characteristics and treatment of temporal bone fractures and injuries in the medial-inner ear. Methods: The clinical data of 48 cases of temporal bone fractures admitted to our hospital from January 1989 to November 1999 were retrospectively analyzed. Results: Forty-eight patients with temporal bone fractures accounted for 17.00 % of the homochronous craniofacial fractures. Of the 48 cases, temporal bone fractures induced by traffic accidents accounted for 66.67 %, capillary fractures for 93.75 %, medial-inner ear injuries or craniocerebral injuries for 77.08 % and hearing loss or tinnitus for 48.00 %. The cerebrospinal fluid (CSF) otorrhea and facioplegia accounted for 36.70 % and 3.00 %, respectively, in the longitudinal fractures, while they were 25.00 % and 37.50 %, respectively, in the transversal fractures. Primary emergent operations were performed on 46 cases and neurosurgery accounted for 46.00 %. Secondary procedures accounted for 16.70 %. As a result, 43 cases survived ( 89.58 %) and 5 died ( 10.41 %). Conclusions: Traffic injury is the first high-dangerous factor for temporal bone fractures, which are often complicated with medial-inner ear or craniocerebral injury. The CSF otorrhea is common in the longitudinal fractures and facioplegia is common in the transversal fractures. The key step is to rescue the life, keep the airway unobstructed and maintain the circulation in the primary emergency treatment.展开更多
文摘Objective: To study the effect of vancomycin (V) with multiple intravenous injections on the inner ear of albino guinea pigs. Methods: Three groups of animals were injected with vancomycin hydrochloride (54, 108, 216 mg/kg respectively once a day for 14 d). Two groups were treated with gentamycin (GM) (80 mg·kg -1 ·d -1 ) and saline respectively as control groups. Auditory brainstem responses (ABR) and the duration of post-rotatory nystagmus (PRN) were measured before and after administration. Surface preparation and scanning electron microscopy (SEM) of the cochlea were performed for histological examination. Results: In V 54, 108 mg/kg group, similar to saline control, there was 0-1.1 dB of threshold shift. In V 216 mg/kg group, average hearing loss was 1.0-5.7 dB immediately after administration and 1.3-3.8 dB after 14 d, which was significantly lower than those in GM control group. As the saline control, no significant difference was found in PRN in all V groups before and after treatment; while in the GM group, PRN decreased significantly after treatment. Morphological evaluation demonstrated that in all V and saline animals there was no obvious missing of outer and inner hair cells and SEM showed normal surface morphology. In the GM group, there was 10%-30% of outer and inner hair cells lost in the basal turn. Conclusion: The ototoxicity of vancomycin is absent or minimal after multiple introvenous administration within this dose range.
文摘Rockfalls can cause serious damage to people,property,facilities and transportation corridors.Furthermore,rockfalls are major hazards in mountain areas with negative impacts on individual trees and forested ecosystems.We conducted a study of rockfall events on 117 mapped(91% of total trees in the stand with>1.3 m in height and>5 cm diameter at breast height)Turkish fir trees(Abies bornmuelleriana Mattf.)in a stand within the Kayaarkasi-Topular Village,Inebolu district, Kastamonu province of Turkey.The study site of 0.35 Ha is located on the transition zone of frequently passing rockfall fragments(～40 cm in diameter) generally causing healable injuries.Parameters of trees and injuries were recorded and analysed as to injury number,height and size.Bivariate correlation analysis were used to investigate the relationships between:a)diameter at breast height and number of injuries per tree,b)diameter at breast height and total injury size,c)the number of injuries and total injury size and d)the number of injuries per tree and distance from the source of the rockfall area.Results indicate that the average height of injury,average number of injuries and average injury area to be 81.3 cm(STDEV:49.8),7.46(STDEV:4.4)and 628.6 cm2 (STDEV:678.2),respectively.In total 84% of all injuries were recorded within 160°sector at the upslope side of trees and callus tissue that had closed wounds was observed in 79.1% of all injuries. Furthermore 14.5% of injured trees had callus tissue in the process of closing wounds while 6.4% of injuries had not formed any callus tissue.The most common injury types were bark and wood injuries. Bivariate correlation analysis indicated strong relationships between diameter at breast height and the number of injuries(rs=0.524),injury number and total injury area(rs=0.653)and distance from rockfall area and injury numbers relations(rs=-0.518).A weaker relationship was found between diameter at breast height and total injury area(rs=0.363).These results indicate that bigger trees are more prone to rockfall injuries.As expected,trees further from the rockfall area seem to be less prone to rockfall injuries.From our results,it can be inferred that the protection of people and property can be increased through the maintanance of forest in areas immediately below areas prone to rockfall.This stand is still managed in selective forest management system.In order to protect the settlement at the deposition zone it has to manage for protective goals with uneven-aged and multilayered stand structure.
文摘Objective:: To explore the characteristics and treatment of temporal bone fractures and injuries in the medial-inner ear. Methods: The clinical data of 48 cases of temporal bone fractures admitted to our hospital from January 1989 to November 1999 were retrospectively analyzed. Results: Forty-eight patients with temporal bone fractures accounted for 17.00 % of the homochronous craniofacial fractures. Of the 48 cases, temporal bone fractures induced by traffic accidents accounted for 66.67 %, capillary fractures for 93.75 %, medial-inner ear injuries or craniocerebral injuries for 77.08 % and hearing loss or tinnitus for 48.00 %. The cerebrospinal fluid (CSF) otorrhea and facioplegia accounted for 36.70 % and 3.00 %, respectively, in the longitudinal fractures, while they were 25.00 % and 37.50 %, respectively, in the transversal fractures. Primary emergent operations were performed on 46 cases and neurosurgery accounted for 46.00 %. Secondary procedures accounted for 16.70 %. As a result, 43 cases survived ( 89.58 %) and 5 died ( 10.41 %). Conclusions: Traffic injury is the first high-dangerous factor for temporal bone fractures, which are often complicated with medial-inner ear or craniocerebral injury. The CSF otorrhea is common in the longitudinal fractures and facioplegia is common in the transversal fractures. The key step is to rescue the life, keep the airway unobstructed and maintain the circulation in the primary emergency treatment.
