目的:了解成人高血压、糖尿病与肥胖的关系,为心脑血管疾病的防治提供依据。方法:参照1995年全国糖尿病流行病学调查操作指南,随机抽取3个生活小区的成人居民作为调查对象。结果:此次调查实际人数为2932人,其中有效资料份数为2891份,有...目的:了解成人高血压、糖尿病与肥胖的关系,为心脑血管疾病的防治提供依据。方法:参照1995年全国糖尿病流行病学调查操作指南,随机抽取3个生活小区的成人居民作为调查对象。结果:此次调查实际人数为2932人,其中有效资料份数为2891份,有效率98.60%。标化后的高血压患病率为10.95%(男12.02%,女9.86%)。标化后的肥胖现患率为3.23%(男3.05%,女3.42%),超重现患率为19.55%(男24.42%,女16.50%)。不同B M I高血压患病率差异有显著性(χ2=113.36,P<0.01)。随着B M I的增大,高血压患病率有逐渐上升的趋势。有651人做空腹血糖、餐后血糖或口服葡萄糖耐量试验。结果显示,B M I≥24葡萄糖耐量异常患病率为11.43%(32/280),高于B M I<24葡萄糖耐量异常的患病率犤6.74%(25/371)犦(χ2=4.39,P<0.05);有高血压者葡萄糖耐量异常患病率为16.38%(19/116),高于无高血压者葡萄糖耐量异常的患病率犤7.10%(38/535)犦(χ2=10.27,P<0.005)。结论:超重、肥胖组的葡萄糖耐量异常患病率及高血压患病率均高于非肥胖组。肥胖与高血压、糖尿病往往共存,是心脑血管疾病的危险因素。控制胰岛素抵抗,去除可能导致胰岛素抵抗的因素,改善高胰岛素血症,对高血压、糖尿病、心脑血管病的防治有着极其重要的意义。展开更多
Recently, obesity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease. There is more and more sufficient evidence that excess body weight is an avoidable cause of excess cancers including ga...Recently, obesity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease. There is more and more sufficient evidence that excess body weight is an avoidable cause of excess cancers including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal cancers. The mechanism that obesity association with cancer is remains not well understood. There be some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors （IGFs）, sex hormones, adipocytokines, intlammatory cytokines, c-Myc （or Myc） oncogenic transcription factor, obesity-induced hypoxia and Warburg effect, and so on. In the future, the potential mechanisms and conclusions in obesity associated with increased risk for developing cancer, and the underlying cellular and molecular mechanisms will be studied.展开更多
文摘目的:了解成人高血压、糖尿病与肥胖的关系,为心脑血管疾病的防治提供依据。方法:参照1995年全国糖尿病流行病学调查操作指南,随机抽取3个生活小区的成人居民作为调查对象。结果:此次调查实际人数为2932人,其中有效资料份数为2891份,有效率98.60%。标化后的高血压患病率为10.95%(男12.02%,女9.86%)。标化后的肥胖现患率为3.23%(男3.05%,女3.42%),超重现患率为19.55%(男24.42%,女16.50%)。不同B M I高血压患病率差异有显著性(χ2=113.36,P<0.01)。随着B M I的增大,高血压患病率有逐渐上升的趋势。有651人做空腹血糖、餐后血糖或口服葡萄糖耐量试验。结果显示,B M I≥24葡萄糖耐量异常患病率为11.43%(32/280),高于B M I<24葡萄糖耐量异常的患病率犤6.74%(25/371)犦(χ2=4.39,P<0.05);有高血压者葡萄糖耐量异常患病率为16.38%(19/116),高于无高血压者葡萄糖耐量异常的患病率犤7.10%(38/535)犦(χ2=10.27,P<0.005)。结论:超重、肥胖组的葡萄糖耐量异常患病率及高血压患病率均高于非肥胖组。肥胖与高血压、糖尿病往往共存,是心脑血管疾病的危险因素。控制胰岛素抵抗,去除可能导致胰岛素抵抗的因素,改善高胰岛素血症,对高血压、糖尿病、心脑血管病的防治有着极其重要的意义。
文摘Recently, obesity is a well-recognized risk factor of type 2 diabetes and cardiovascular disease. There is more and more sufficient evidence that excess body weight is an avoidable cause of excess cancers including gastrointestinal, endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal cancers. The mechanism that obesity association with cancer is remains not well understood. There be some most studied hypothesized mechanisms such as, high levels of insulin and free levels of insulin-like growth factors （IGFs）, sex hormones, adipocytokines, intlammatory cytokines, c-Myc （or Myc） oncogenic transcription factor, obesity-induced hypoxia and Warburg effect, and so on. In the future, the potential mechanisms and conclusions in obesity associated with increased risk for developing cancer, and the underlying cellular and molecular mechanisms will be studied.
