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伤科接骨片对家兔骨折模型肾组织转化生长因子-β_1表达的影响 被引量:3
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作者 张继平 张奋耿 +5 位作者 宫丽 姚晖 邱建文 林爱华 许碧莲 吴铁 《广州中医药大学学报》 CAS 2008年第4期316-318,324,共4页
【目的】观察伤科接骨片对模型家兔骨折愈合过程中肾组织转化生长因子-β1(TGF-β1)表达变化的影响。【方法】选用36只雄性新西兰家兔,均复制成单侧桡骨中上1/3标准骨折模型;随机分为模型对照组和伤科接骨片组,每组18只,每组再分3个亚组... 【目的】观察伤科接骨片对模型家兔骨折愈合过程中肾组织转化生长因子-β1(TGF-β1)表达变化的影响。【方法】选用36只雄性新西兰家兔,均复制成单侧桡骨中上1/3标准骨折模型;随机分为模型对照组和伤科接骨片组,每组18只,每组再分3个亚组,每个亚组6只。术后第2天开始给药,于术后第11、21和35天分别处死各亚组动物,取肾脏,采用免疫组化染色,应用图像分析的方法测定肾组织TGF-β1表达含量。【结果】第11天和第21天时伤科接骨片组肾组织TGF-β1的表达水平均较模型对照组显著提高(P<0.05或P<0.01);第35天时伤科接骨片组与模型对照组比较差异无显著性意义(P>0.05)。【结论】伤科接骨片促进骨折愈合的作用可能与其调节肾组织TGF-β1表达水平有关。 展开更多
关键词 伤科接骨片/药理学 骨折/中药疗法 肾组织/病理学 疾病模型 动物
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通脉口服液对实验性糖尿病肾病模型大鼠肾脏病理及转化生长因子β_1的影响 被引量:7
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作者 范萍 杨霓芝 《广州中医药大学学报》 CAS 2008年第6期514-518,共5页
【目的】观察通脉口服液对实验性糖尿病肾病(DN)模型大鼠肾脏病理及转化生长因子β1(TGFβ-1)的影响。【方法】选用SD雄性大鼠40例,随机分为正常对照组(8只)和造模组(32只)。正常对照组给予腹腔注射55 mg/kg无菌柠檬酸—柠檬酸钠缓冲液... 【目的】观察通脉口服液对实验性糖尿病肾病(DN)模型大鼠肾脏病理及转化生长因子β1(TGFβ-1)的影响。【方法】选用SD雄性大鼠40例,随机分为正常对照组(8只)和造模组(32只)。正常对照组给予腹腔注射55 mg/kg无菌柠檬酸—柠檬酸钠缓冲液,饲普通饲料;造模组给予链脲佐菌素(STZ,剂量为55 mg/kg)单次腹腔注射,隔日饲高脂饲料,4周后筛选造模成功DN大鼠共21只,随机分为模型组(11只)和通脉组(10只)。通脉组给予通脉口服液(剂量为2.5.gkg-1.d-1),正常对照组及模型组给予生理盐水灌胃,饲料同前。6周后处死大鼠取肾组织,光学显微镜及电子显微镜下观察肾脏组织形态及超微结构变化,测量肾小球截面积(AMG)、细胞外基质截面积(AMM)、肾小球基底膜(GBM)厚度,计算AMM/AMG比值;同时采用免疫组化法测定肾组织TGFβ-1蛋白表达。【结果】肾组织病理形态学:通脉组系膜区增宽、基底膜增厚及肾小管上皮细胞空泡变性等均较模型组明显减轻;通脉组AMM/AMG值较模型组降低;GBM厚度较模型组变薄(均P<0.001);TGFβ-1主要定位在肾小管及间质处,肾小球表达较弱,通脉组免疫组化染色面密度及积分光密度均较模型组降低(P<0.001)。【结论】益气活血中药复方通脉口服液可能通过抑制肾组织TGFβ-1表达,减轻肾脏病理损害,发挥对DN的肾脏保护作用。 展开更多
关键词 通脉口服液/药理学 糖尿病病/中药疗法 肾组织/病理学 组织/超微结构 疾病模型 动物 大鼠
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Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome 被引量:7
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作者 Hong-sheng LU Mei-fu GAN Han-song CHEN Shan-qiang HUANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2008年第6期500-505,共6页
The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare,for both tumors present usually as separate entities.There are only 16 such cases reported worldwide.To the best of our knowledge,the ca... The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare,for both tumors present usually as separate entities.There are only 16 such cases reported worldwide.To the best of our knowledge,the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported.A 32-year-old Chinese woman with 4-year history of hypertension was presented in our study.Computed tomography(CT)of the abdomen showed a large heterogene- ously-enhancing mass(4.5 cm in diameter)in the left suprarenal region.Clinical history and laboratory results suggest a metabolic disorder as Conn's syndrome.The patient underwent a left adrenalectomy,and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing myelolipoma.The patient was postoperatively well and discharged uneventfully.In the present case report,we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with Conn's syndrome,and the methods of the diagnosis and differential diagnosis. 展开更多
关键词 Adrenal gland Myxoid adrenal cortical adenoma MYELOLIPOMA Conn's syndrome PATHOLOGY IMMUNOHISTOCHEMISTRY
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Pseudomelanosis duodeni associated with chronic renal failure 被引量:2
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作者 Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado +4 位作者 Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第12期1414-1416,共3页
Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We ... Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. 展开更多
关键词 Pseudomelanosis duodeni Chronic renal fail-ure Diabetes mellitus Anti hypertensive drugs Gastro-duodenal endoscopy
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Renal Collecting Duct Cancer: a Report of 2 Cases
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作者 Shiying Zhou 《Chinese Journal of Clinical Oncology》 CSCD 2005年第5期834-836,共3页
Renal collecting duct cancer is a rare malignant tumor, which accounts for 1% to 2% of epithelial kidney tumors. Its pathologial appearance has been easily misdiagnosed as a mammilliform renal cell carcinoma or as oth... Renal collecting duct cancer is a rare malignant tumor, which accounts for 1% to 2% of epithelial kidney tumors. Its pathologial appearance has been easily misdiagnosed as a mammilliform renal cell carcinoma or as other tumors. The malignancy of renal collecting duct cancer is high, with early metastasis and poor prognosis. The clinical data for 2 cases of the tumor are discussed in this report, including reports on the histopathology and the changes in immunohistochemistry. 展开更多
关键词 collecting duct cancer case report.
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Evaluation of nephron sparing surgery for renal tumors:a single institution experience
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作者 Hytham Abd-elkareem Ahmed Abdelhamid Hussein Ezzat Ismael Mourad 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第9期517-522,共6页
Objective:The aim of the study was to report the experience of National Cancer Institute(NCI),Cairo University,Egypt,in managing various benign and malignant renal tumors with nephron sparing surgery(NSS),and to asses... Objective:The aim of the study was to report the experience of National Cancer Institute(NCI),Cairo University,Egypt,in managing various benign and malignant renal tumors with nephron sparing surgery(NSS),and to assess its safety and feasibility.Methods:Reviewing the literature for NSS,and records of patients who underwent NSS in the period from January 2000 to December 2009 at National Cancer Institute,Cairo University regarding the patient and tumor related characteristics,the indication for NSS,operative technique,postoperative complications,full histopathological data,and follow up results.Results:The total number of patients was 17.Mean age at surgery was 30.7 years(range 1.5-65 years).Five patients had bilateral tumors during surgery.The mean tumor size was 4.5 cm(range 1-9 cm).All patients had normal preoperative kidney functions.Seven patients had an absolute indication for NSS,6 patients had a relative indication,and 4 patients had an elective indication.All the 5 patients with bilateral tumors underwent bilateral simultaneous surgery.Cold ischemia was used in 8 patients,1 patient was exposed to warm ischemia,manual compression was used in 2 patients,and no vascular control was applied in 6 patients.Complications were encountered in 2 patients,one of them had urinary leakage which needed reoperation,and the other had subcutaneous hematoma which was treated conservatively.Histopathological analysis revealed Wilm's tumor(8 patients),angiomyolipoma(4 patients),renal cell carcinoma(4 patients),and hydatid cyst(1 patient).All patients had negative surgical margin.For patients with Wilm's tumor,the mean follow up was 21.4 months(range 0-94 months),2 patients had local recurrence,and 1 patient had distant metastasis.For patients with RCC,the mean follow up was 15.3 months(5-33 months),no patients had local recurrence or distant metastasis.All patients had normal kidney functions during postoperative and follow up periods.Conclusion:NSS is a feasible safe procedure that can be done with acceptable complications rate and it provides a good solution for patients with bilateral tumors,early localized renal cell carcinoma,and benign tumors. 展开更多
关键词 nephron sparing surgery(NSS) renal tumors EVALUATION
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