Tumor-associated carbohydrate antigens （TACAs）, important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity,...Tumor-associated carbohydrate antigens （TACAs）, important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity, native TACAs cannot induce powerful immune response. The use of modified TACAs such as N-glycosides could be an alternative strategy to overcome this problem. Herein, the synthesis of N（OMe）-linked analogue of tumor-associated disaccharide antigen Thomsen-Friedenreich （TF） by the glycosylation reaction is described.展开更多
Modified tumor-associated carbohydrate antigens could be used to develop anti-cancer vaccines.Carbohydrate antigens in which thioglycosidic linkages are used instead of O-glycosidic linkages may be more immunogenic an...Modified tumor-associated carbohydrate antigens could be used to develop anti-cancer vaccines.Carbohydrate antigens in which thioglycosidic linkages are used instead of O-glycosidic linkages may be more immunogenic and may stimulate the production of antibodies capable of recognizing naturally occurring carbohydrates due to their enhanced resistance to endogenous glycosidases and their inherent non-self antigen character.For this purpose,a new S-linked tumor-associated carbohydrate antigen STn has been successfully synthesized for the first time.展开更多
基金Grant from the Ministry of Science and Technology of China(Grant No.2012ZX09502001-001)the National Natural Science Foundation of China(Grant No.81172916)
文摘Tumor-associated carbohydrate antigens （TACAs）, important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity, native TACAs cannot induce powerful immune response. The use of modified TACAs such as N-glycosides could be an alternative strategy to overcome this problem. Herein, the synthesis of N（OMe）-linked analogue of tumor-associated disaccharide antigen Thomsen-Friedenreich （TF） by the glycosylation reaction is described.
基金National Natural Science Foundation of China(Grant No.20732001).
文摘Modified tumor-associated carbohydrate antigens could be used to develop anti-cancer vaccines.Carbohydrate antigens in which thioglycosidic linkages are used instead of O-glycosidic linkages may be more immunogenic and may stimulate the production of antibodies capable of recognizing naturally occurring carbohydrates due to their enhanced resistance to endogenous glycosidases and their inherent non-self antigen character.For this purpose,a new S-linked tumor-associated carbohydrate antigen STn has been successfully synthesized for the first time.
