Mitchell's solution is commonly used to determine the required strength of vertically exposed cemented backfill in mines. Developed for drained backfill, Mitchell model assumed a zero friction angle for the backfi...Mitchell's solution is commonly used to determine the required strength of vertically exposed cemented backfill in mines. Developed for drained backfill, Mitchell model assumed a zero friction angle for the backfill. Physical model tests were performed. Good agreements were obtained between the required strengths predicted by the analytical solution and experimental results. However, it is well-known that zero friction angle can only be possible in terms of total stresses when geomaterials are submitted to unconsolidated and undrained conditions. A revisit to Mitchell's physical model tests reveals that both the laboratory tests performed for obtaining the shear strength parameters of the cemented backfill and the box stability tests were conducted under a condition close to undrained condition. This explains well the good agreement between Mitchell's solution and experimental results. Good agreements are equally obtained between Mitchell's experimental results and FLAC3 D numerical modeling of shortterm stability analyses of exposed cemented backfill.展开更多
Using the self-designed testing system, the seepage tests for cemented broken rocks were conducted, and the impact of different factors on water-resisting ability was analyzed. The results show that(1) seepage process...Using the self-designed testing system, the seepage tests for cemented broken rocks were conducted, and the impact of different factors on water-resisting ability was analyzed. The results show that(1) seepage process of the cemented broken rocks can be divided into two categories: in one category, seepage instability occurs after a period of time, in the other, the permeability decreases slowly and tends to be stable,and seepage instability does not occur;(2) cementing performance of cementing agent and grain size distribution are the decisive factors for water-resisting ability, with the increase of cementing performance and the mass percentage of large grains, the water-resisting ability of the specimen strengthens;(3)aggregate type has little effect on seepage stability, for the specimens with different aggregate types,the permeability and the duration of seepage instability have small difference;(4) initial porosity has a certain effect on the water-resisting ability of the specimen, but has no decisive role. With the increase of the initial porosity, the duration of seepage instability decreases.展开更多
AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(gr...AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.展开更多
New and high transparent structural element, steel-glass composite beam was developed in respect to fabrication, static-structural and architectural criteria and consists of steel flanges and glass web assembled toget...New and high transparent structural element, steel-glass composite beam was developed in respect to fabrication, static-structural and architectural criteria and consists of steel flanges and glass web assembled together by semi-rigid polymer adhesive, which is the key element of whole composite system. These beams can be used mainly as members of high transparent roof or floor structure as well as stiffening fins for large area glass facades. This paper deals with experimental research performed at CTU （Czech Technical University） Prague, which started by adhesive selection and initial material tests by ISO527, continued via small-scale steel-glass connection tests and graduated by full-scale tests of hybrid beams with the span of 4 m. Generalized results of these experiments, analytical and numerical studies serve as device, how to accurately predict the behavior of the beam, describe the stress distribution along the cross section and safely and economically design such a kind of structure with semi-rigid shear connection, made by polymer adhesive.展开更多
OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells BxPC-3.METHODS:The human pancreatic cancer cells BxPC-3 were treated with JLC at the co...OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells BxPC-3.METHODS:The human pancreatic cancer cells BxPC-3 were treated with JLC at the concentration of 0.05-1.00 mg/mL for 24-120 h.The inhibition rate of JLC on human pancreatic cancer cells BxPC-3 was detected by 3-(4,5-dimethiylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay.Flow cytometry was employed to measure cell apoptosis using Annexin V-FITC/Propidium iodide(AV-FITC/PI) method.Cell cycles were determined by PI staining.The expression of S100 Calcium binding protein A4(S100A4) in cell matrix was measured by enzyme-linked immunosorbent assay(ELISA).The expression levels of apoptosis-related protein such as BCL2/adenovirus E1B 19 kDa interacting protein 3(BNIP3),B-cell lymphoma/leukemia-2(Bcl-2) and Cys-teinylaspartate specific proteinase 3(Caspase-3) were detected byWestern blotting.RESULTS:JLC significantly inhibited the proliferation of human pancreatic cancer cells BxPC-3 in a dose-dependent and time-dependent manner.JLC promoted cell apoptosis and maintained cell cycle in S and G 2 /M phase rather than G 1 /G 0 phase.The expression of S100A4 in the cell matrix was reduced.The expression of cell apoptotic protein BNIP3 was increased while Bcl-2 was decreased.CONCLUSION:JLC can inhibit the proliferation of human pancreatic cancer cells BxPC-3 by stimulating cell apoptosis,arresting the cell cycle at S and G 2 /M phase which blocks the circulation of normal cell cycle and reducing the expression of S100A4 protein.Higher pro-apoptosis protein BNIP3 and lower anti-apoptosis protein Bcl-2 levels were found,which may be related to the apoptotic effects of JLC.展开更多
基金financial support from China Scholarship Council(CSC)under the Grant CSC No.201406460041financial support from the Natural Sciences and Engineering Research Council of Canada(NSERC 402318)+4 种基金the Institut de Recherche Robert-Sauvéen Santéet en Sécuritédu Travail(IRSST 2013-0029)Fonds de Recherche du Québec-Nature et Technologies(FRQNT 2015-MI-191676)the industrial partners of Research Institute on Mines and Environment(RIME UQAT-Polytechnique)The financial support from the National Science and Technology Support Program of China(No.2013BAB02B02)the Scientific Research Fund of Beijing General Research Institute of Mining and Metallurgy of China(No.YJ201507)
文摘Mitchell's solution is commonly used to determine the required strength of vertically exposed cemented backfill in mines. Developed for drained backfill, Mitchell model assumed a zero friction angle for the backfill. Physical model tests were performed. Good agreements were obtained between the required strengths predicted by the analytical solution and experimental results. However, it is well-known that zero friction angle can only be possible in terms of total stresses when geomaterials are submitted to unconsolidated and undrained conditions. A revisit to Mitchell's physical model tests reveals that both the laboratory tests performed for obtaining the shear strength parameters of the cemented backfill and the box stability tests were conducted under a condition close to undrained condition. This explains well the good agreement between Mitchell's solution and experimental results. Good agreements are equally obtained between Mitchell's experimental results and FLAC3 D numerical modeling of shortterm stability analyses of exposed cemented backfill.
基金Financial support for this work,provided by the National Basic Research Program of China(No.2013CB227900)the Ordinary University Graduate Student Research Innovation Project in Jiangsu Province for 2014 of China(KYLX_1370)the National Natural Science Foundation of China(No.51404266),are gratefully acknowledged
文摘Using the self-designed testing system, the seepage tests for cemented broken rocks were conducted, and the impact of different factors on water-resisting ability was analyzed. The results show that(1) seepage process of the cemented broken rocks can be divided into two categories: in one category, seepage instability occurs after a period of time, in the other, the permeability decreases slowly and tends to be stable,and seepage instability does not occur;(2) cementing performance of cementing agent and grain size distribution are the decisive factors for water-resisting ability, with the increase of cementing performance and the mass percentage of large grains, the water-resisting ability of the specimen strengthens;(3)aggregate type has little effect on seepage stability, for the specimens with different aggregate types,the permeability and the duration of seepage instability have small difference;(4) initial porosity has a certain effect on the water-resisting ability of the specimen, but has no decisive role. With the increase of the initial porosity, the duration of seepage instability decreases.
基金Supported by Foundation for Promotion of Cancer Research by Ministry of Health,Labor and Welfare in Japan
文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.
文摘New and high transparent structural element, steel-glass composite beam was developed in respect to fabrication, static-structural and architectural criteria and consists of steel flanges and glass web assembled together by semi-rigid polymer adhesive, which is the key element of whole composite system. These beams can be used mainly as members of high transparent roof or floor structure as well as stiffening fins for large area glass facades. This paper deals with experimental research performed at CTU （Czech Technical University） Prague, which started by adhesive selection and initial material tests by ISO527, continued via small-scale steel-glass connection tests and graduated by full-scale tests of hybrid beams with the span of 4 m. Generalized results of these experiments, analytical and numerical studies serve as device, how to accurately predict the behavior of the beam, describe the stress distribution along the cross section and safely and economically design such a kind of structure with semi-rigid shear connection, made by polymer adhesive.
文摘OBJECTIVE:To study the possible roles of Jinlong capsule(JLC) on the proliferation and apoptosis of human pancreatic cancer cells BxPC-3.METHODS:The human pancreatic cancer cells BxPC-3 were treated with JLC at the concentration of 0.05-1.00 mg/mL for 24-120 h.The inhibition rate of JLC on human pancreatic cancer cells BxPC-3 was detected by 3-(4,5-dimethiylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay.Flow cytometry was employed to measure cell apoptosis using Annexin V-FITC/Propidium iodide(AV-FITC/PI) method.Cell cycles were determined by PI staining.The expression of S100 Calcium binding protein A4(S100A4) in cell matrix was measured by enzyme-linked immunosorbent assay(ELISA).The expression levels of apoptosis-related protein such as BCL2/adenovirus E1B 19 kDa interacting protein 3(BNIP3),B-cell lymphoma/leukemia-2(Bcl-2) and Cys-teinylaspartate specific proteinase 3(Caspase-3) were detected byWestern blotting.RESULTS:JLC significantly inhibited the proliferation of human pancreatic cancer cells BxPC-3 in a dose-dependent and time-dependent manner.JLC promoted cell apoptosis and maintained cell cycle in S and G 2 /M phase rather than G 1 /G 0 phase.The expression of S100A4 in the cell matrix was reduced.The expression of cell apoptotic protein BNIP3 was increased while Bcl-2 was decreased.CONCLUSION:JLC can inhibit the proliferation of human pancreatic cancer cells BxPC-3 by stimulating cell apoptosis,arresting the cell cycle at S and G 2 /M phase which blocks the circulation of normal cell cycle and reducing the expression of S100A4 protein.Higher pro-apoptosis protein BNIP3 and lower anti-apoptosis protein Bcl-2 levels were found,which may be related to the apoptotic effects of JLC.
