患者女,86岁.于凌晨1:00醒来时突然出现视物模糊,左侧上、下肢体运动障碍就诊.体格检查:意识模糊,血压105/75 mm Hg(1 mm Hg=0.133 kPa).心率80次/min,律齐;双肺呼吸音粗糙;左侧中枢性面瘫,伸舌偏左;左侧肢体弛缓性瘫痪,上肢肌力0级,下...患者女,86岁.于凌晨1:00醒来时突然出现视物模糊,左侧上、下肢体运动障碍就诊.体格检查:意识模糊,血压105/75 mm Hg(1 mm Hg=0.133 kPa).心率80次/min,律齐;双肺呼吸音粗糙;左侧中枢性面瘫,伸舌偏左;左侧肢体弛缓性瘫痪,上肢肌力0级,下肢肌力Ⅱ级;右侧肢体肌张力、肌力正常;双侧巴宾斯基征阳性.患者平素健康,否认高血压、糖尿病及其他特殊疾病史;近2 d因咳嗽静脉点滴青霉素治疗.展开更多
Most therapies under development to restore motor function after spinal cord injury (SCI) assume intact brain motor functions. To examine this assumption, 12 patients with chronic, complete SCI and 12 controls underwe...Most therapies under development to restore motor function after spinal cord injury (SCI) assume intact brain motor functions. To examine this assumption, 12 patients with chronic, complete SCI and 12 controls underwent functional MRI during attempted, and during imagined, right foot movement, each at two force levels. In patients with SCI, many features of normal motor system function were preserved, however, several departures from normal were apparent: (i) volume of activation was generally much reduced, e.g. 4-8%of normal in primary sensorimotor cortex, in the setting of twice normal variance in signal change; (ii) abnormal activation patterns were present, e.g. increased pallido-thalamocortical loop activity during attempted movement and abnormal processing in primary sensorimotor cortex during imagined movement; and (iii) modulation of function with change in task or in force level did not conform to patterns seen in controls, e.g. in controls, attempted movement activated more than imagined movement did within left primary sensorimotor cortex and right dorsal cerebellum, while imagined movement activated more than attempted movement did in dorsolateral prefrontal cortex and right precentral gyrus. These modulations were absent in patients with SCI. Many features of brain motor system function during foot movement persist after chronic complete SCI. However, substantial derangements of brain activation, poor modulation of function with change in task demands and emergence of pathological brain events were present in patients. Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function.展开更多
文摘患者女,86岁.于凌晨1:00醒来时突然出现视物模糊,左侧上、下肢体运动障碍就诊.体格检查:意识模糊,血压105/75 mm Hg(1 mm Hg=0.133 kPa).心率80次/min,律齐;双肺呼吸音粗糙;左侧中枢性面瘫,伸舌偏左;左侧肢体弛缓性瘫痪,上肢肌力0级,下肢肌力Ⅱ级;右侧肢体肌张力、肌力正常;双侧巴宾斯基征阳性.患者平素健康,否认高血压、糖尿病及其他特殊疾病史;近2 d因咳嗽静脉点滴青霉素治疗.
文摘Most therapies under development to restore motor function after spinal cord injury (SCI) assume intact brain motor functions. To examine this assumption, 12 patients with chronic, complete SCI and 12 controls underwent functional MRI during attempted, and during imagined, right foot movement, each at two force levels. In patients with SCI, many features of normal motor system function were preserved, however, several departures from normal were apparent: (i) volume of activation was generally much reduced, e.g. 4-8%of normal in primary sensorimotor cortex, in the setting of twice normal variance in signal change; (ii) abnormal activation patterns were present, e.g. increased pallido-thalamocortical loop activity during attempted movement and abnormal processing in primary sensorimotor cortex during imagined movement; and (iii) modulation of function with change in task or in force level did not conform to patterns seen in controls, e.g. in controls, attempted movement activated more than imagined movement did within left primary sensorimotor cortex and right dorsal cerebellum, while imagined movement activated more than attempted movement did in dorsolateral prefrontal cortex and right precentral gyrus. These modulations were absent in patients with SCI. Many features of brain motor system function during foot movement persist after chronic complete SCI. However, substantial derangements of brain activation, poor modulation of function with change in task demands and emergence of pathological brain events were present in patients. Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function.
