期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
智慧化博物馆馆藏纸质文物保护与修复技术研究
1
作者 赵苑琳 张永恒 《造纸科学与技术》 2024年第4期66-69,共4页
物联网技术在博物馆文物保护中的应用,可以有效提升博物馆文物保护的智慧化水平,更加契合智慧博物馆的发展要求。纸质文物作为人类文化遗产的重要组成部分,承载着丰富的历史、文化与知识信息。随着时间推移和环境侵蚀,这些珍贵的文献正... 物联网技术在博物馆文物保护中的应用,可以有效提升博物馆文物保护的智慧化水平,更加契合智慧博物馆的发展要求。纸质文物作为人类文化遗产的重要组成部分,承载着丰富的历史、文化与知识信息。随着时间推移和环境侵蚀,这些珍贵的文献正遭受着或许无法挽回的损害。因此,对智慧化博物馆纸质文物进行修复和保护的重要性及其面临的挑战进行研究成为必要。基于此,阐述了现代修复技术的进步和在智慧化博物馆纸质文物保护中的重要作用,特别是细菌纤维素加固法、超声雾化脱酸技术与各类清洁技术的实践应用,进一步完善了智慧化纸质文物的保护与修复策略,旨在为博物馆的文物保护工作提供科学、有效的参考和指导。 展开更多
关键词 博物馆 纸质文物 脱酸修复 清洁技术 字迹保护
原文传递
Regulation of DNA double-strand break repair pathway choice 被引量:68
2
作者 Meena Shrivastav Leyma P De Haro Jac A Nickoloff 《Cell Research》 SCIE CAS CSCD 2008年第1期134-147,共14页
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide variety of genetic alterations including largeor small-scale deletions, loss of heterozygosity, translocations, and chromo... DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide variety of genetic alterations including largeor small-scale deletions, loss of heterozygosity, translocations, and chromosome loss. DSBs are repaired by non-homologous end-joining (NHEJ) and homologous recombination (HR), and defects in these pathways cause genome instability and promote tumorigenesis. DSBs arise from endogenous sources including reactive oxygen species generated during cellular metabolism, collapsed replication forks, and nucleases, and from exogenous sources including ionizing radiation and chemicals that directly or indirectly damage DNA and are commonly used in cancer therapy. The DSB repair pathways appear to compete for DSBs, but the balance between them differs widely among species, between different cell types of a single species, and during different cell cycle phases of a single cell type. Here we review the regulatory factors that regulate DSB repair by NHEJ and HR in yeast and higher eukaryotes. These factors include regulated expression and phosphorylation of repair proteins, chromatin modulation of repair factor accessibility, and the availability of homologous repair templates. While most DSB repair proteins appear to function exclusively in NHEJ or HR, a number of proteins influence both pathways, including the MRE11/RAD50/NBS1(XRS2) complex, BRCA1, histone H2AX, PARP-1, RAD18, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and ATM. DNA-PKcs plays a role in mammalian NHEJ, but it also influences HR through a complex regulatory network that may involve crosstalk with ATM, and the regulation of at least 12 proteins involved in HR that are phosphorylated by DNA-PKcs and/or ATM. 展开更多
关键词 DNA repair non-homologous end-joining homologous recombination DNA-PK ATM CHROMATIN genome stability
下载PDF
Mechanisms and functions of DNA mismatch repair 被引量:54
3
作者 Guo-Min Li 《Cell Research》 SCIE CAS CSCD 2008年第1期85-98,共14页
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs... DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous recombination and was recently shown to play a role in DNA damage signaling in eukaryotic cells. Escherichia coli MutS and MutL and their eukaryotic homologs, MutSα and MutLα, respectively, are key players in MMR-associated genome maintenance. Many other protein components that participate in various DNA metabolic pathways, such as PCNA and RPA, are also essential for MMR. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. 展开更多
关键词 MUTS MUTL microsatellite instability CANCER
下载PDF
A brief history of the DNA repair field 被引量:7
4
作者 Errol C Friedberg 《Cell Research》 SCIE CAS CSCD 2008年第1期3-7,共5页
The history of the repair of damaged DNA can be traced to the mid-1930s. Since then multiple DNA repair mechanisms, as well as other biological responses to DNA damage, have been discovered and their regulation has be... The history of the repair of damaged DNA can be traced to the mid-1930s. Since then multiple DNA repair mechanisms, as well as other biological responses to DNA damage, have been discovered and their regulation has been studied. This article briefly recounts the early history of this field. 展开更多
关键词 DNA repair biological responses to DNA damage ultraviolet light excision repair enzymatic photoreactivation mismatch repair DNA damage tolerance recombination
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部