自身免疫性疾病(autoimmune diseases,AID)病情复杂、病程漫长,大多需要长期用药。传统治疗药物长期使用不仅有耐药倾向,且存在一定不良反应,临床迫切需要高效低毒的替代药物。本文对近20年国内青蒿素衍生物(artemisinin and its deriva...自身免疫性疾病(autoimmune diseases,AID)病情复杂、病程漫长,大多需要长期用药。传统治疗药物长期使用不仅有耐药倾向,且存在一定不良反应,临床迫切需要高效低毒的替代药物。本文对近20年国内青蒿素衍生物(artemisinin and its derivatives,ARTs)治疗自身免疫性疾病研究文献进行了知识图谱可视化分析。我国ARTs治疗AID相关领域初步形成少数研究团队,研究方式多为基础医学实验,研究内容聚焦在该类药物对类风湿关节炎(rheumatoid arthritis,RA)、系统性红斑狼疮(systemic lupus erythematosus,SLE)等疾病疗效作用机制方面。研究发现ARTs对AID发生发展过程中的多个环节均有干预作用,包括免疫细胞功能紊乱、炎症通路异常激活、组织细胞异常分化等。ARTs在治疗AID中展现出了强大的治疗潜力,有望成为治疗AID的新型药物。目前研究尚局限于机制探索、基础实验干预等,相关临床研究亟待开展以验证其有效性与安全性。展开更多
半数以上早发性卵巢功能不全(Premature ovarian insufficiency, POI)病因尚未明确,其中免疫因素占4%~30%。POI可单独发病,但有时也与自身免疫性疾病并存,如自身免疫性甲状腺疾病(AITD)、原发性慢性肾上腺皮质功能减退症(Addsion病)、...半数以上早发性卵巢功能不全(Premature ovarian insufficiency, POI)病因尚未明确,其中免疫因素占4%~30%。POI可单独发病,但有时也与自身免疫性疾病并存,如自身免疫性甲状腺疾病(AITD)、原发性慢性肾上腺皮质功能减退症(Addsion病)、系统性红斑狼疮等。因免疫系统异常活跃,卵巢常为其相关攻击靶点,自身免疫抗体(抗卵巢抗体、类固醇自身抗体)、免疫细胞、肿瘤坏死因子α、白细胞介素6等与POI的免疫相关发病机制有着密切的联系。The etiology of more than half of premature ovarian insufficiency (POI) has not been clarified, with immunologic factors accounting for 4%~30% of the cases. POI can develop alone, but sometimes coexists with autoimmune diseases, such as autoimmune thyroid disease (AITD), primary chronic adrenocortical hypoplasia (Addsion disease), systemic lupus erythematosus (SLE), and others. Due to the abnormal activity of the immune system, the ovary is often the target of attack, and autoimmune antibodies (anti-ovarian antibodies, steroid autoantibodies), immune cells, tumor necrosis factor-alpha, and interleukin 6 are closely related to the immune-related pathogenesis of POI.展开更多
文摘自身免疫性疾病(autoimmune diseases,AID)病情复杂、病程漫长,大多需要长期用药。传统治疗药物长期使用不仅有耐药倾向,且存在一定不良反应,临床迫切需要高效低毒的替代药物。本文对近20年国内青蒿素衍生物(artemisinin and its derivatives,ARTs)治疗自身免疫性疾病研究文献进行了知识图谱可视化分析。我国ARTs治疗AID相关领域初步形成少数研究团队,研究方式多为基础医学实验,研究内容聚焦在该类药物对类风湿关节炎(rheumatoid arthritis,RA)、系统性红斑狼疮(systemic lupus erythematosus,SLE)等疾病疗效作用机制方面。研究发现ARTs对AID发生发展过程中的多个环节均有干预作用,包括免疫细胞功能紊乱、炎症通路异常激活、组织细胞异常分化等。ARTs在治疗AID中展现出了强大的治疗潜力,有望成为治疗AID的新型药物。目前研究尚局限于机制探索、基础实验干预等,相关临床研究亟待开展以验证其有效性与安全性。
文摘半数以上早发性卵巢功能不全(Premature ovarian insufficiency, POI)病因尚未明确,其中免疫因素占4%~30%。POI可单独发病,但有时也与自身免疫性疾病并存,如自身免疫性甲状腺疾病(AITD)、原发性慢性肾上腺皮质功能减退症(Addsion病)、系统性红斑狼疮等。因免疫系统异常活跃,卵巢常为其相关攻击靶点,自身免疫抗体(抗卵巢抗体、类固醇自身抗体)、免疫细胞、肿瘤坏死因子α、白细胞介素6等与POI的免疫相关发病机制有着密切的联系。The etiology of more than half of premature ovarian insufficiency (POI) has not been clarified, with immunologic factors accounting for 4%~30% of the cases. POI can develop alone, but sometimes coexists with autoimmune diseases, such as autoimmune thyroid disease (AITD), primary chronic adrenocortical hypoplasia (Addsion disease), systemic lupus erythematosus (SLE), and others. Due to the abnormal activity of the immune system, the ovary is often the target of attack, and autoimmune antibodies (anti-ovarian antibodies, steroid autoantibodies), immune cells, tumor necrosis factor-alpha, and interleukin 6 are closely related to the immune-related pathogenesis of POI.
