布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),...布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),是由布鲁氏菌侵犯脊柱(椎间盘、椎体、肌肉)导致的脊柱感染性疾病,约占布病患者的2%~53%。主要临床表现为发热、乏力、夜间盗汗、厌食、头痛、肝脾肿大、关节疼痛、腰背痛等全身及局部症状。本文旨在深入阐述BS的致病机制、分型技术及实验室检查的最新进展。Brucellosis is a zoonotic disease caused by Brucella, which is transmitted from animals. Brucella infection in the human body can affect multiple organs and systems, among which bone and joint system lesions are the most common complications, and are common in the spine. Brucella spondylitis, also known as brucella spondylitis (BS), is a spinal infectious diseases caused by brucella invading the spine (intervertebral disc, vertebral body, muscle), accounting for 2% to 53% of patients with brucellosis. The main clinical manifestations include fever, fatigue, night sweats, anorexia, headache, hepatosplenomegaly, joint pain, lower back pain, and other systemic and local symptoms. This article aims to provide an in-depth explanation of the pathogenesis, typing techniques, and latest developments in laboratory testing of BS.展开更多
新发现!宋伟宏院士团队揭秘儿童罕见病致病机制近日,加拿大健康科学院院士,温州医科大学学术副校长、老年研究院院长,瓯江实验室主任宋伟宏院士团队在Nature Communications发表了题为“Diphthamide deficiency promotes association of...新发现!宋伟宏院士团队揭秘儿童罕见病致病机制近日,加拿大健康科学院院士,温州医科大学学术副校长、老年研究院院长,瓯江实验室主任宋伟宏院士团队在Nature Communications发表了题为“Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects”的研究论文,发现白喉酰胺生物合成1(diphthamide biosynthesis 1,DPH1)基因突变在儿童罕见病“发育迟缓、身材矮小和头发稀疏综合征”(developmental delay,short stature,and sparse hair syndrome,DEDSSH)中的致病机制,为DEDSSH及认知和发育障碍相关疾病的药物开发和治疗提供了新靶点。展开更多
文摘布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),是由布鲁氏菌侵犯脊柱(椎间盘、椎体、肌肉)导致的脊柱感染性疾病,约占布病患者的2%~53%。主要临床表现为发热、乏力、夜间盗汗、厌食、头痛、肝脾肿大、关节疼痛、腰背痛等全身及局部症状。本文旨在深入阐述BS的致病机制、分型技术及实验室检查的最新进展。Brucellosis is a zoonotic disease caused by Brucella, which is transmitted from animals. Brucella infection in the human body can affect multiple organs and systems, among which bone and joint system lesions are the most common complications, and are common in the spine. Brucella spondylitis, also known as brucella spondylitis (BS), is a spinal infectious diseases caused by brucella invading the spine (intervertebral disc, vertebral body, muscle), accounting for 2% to 53% of patients with brucellosis. The main clinical manifestations include fever, fatigue, night sweats, anorexia, headache, hepatosplenomegaly, joint pain, lower back pain, and other systemic and local symptoms. This article aims to provide an in-depth explanation of the pathogenesis, typing techniques, and latest developments in laboratory testing of BS.
文摘新发现!宋伟宏院士团队揭秘儿童罕见病致病机制近日,加拿大健康科学院院士,温州医科大学学术副校长、老年研究院院长,瓯江实验室主任宋伟宏院士团队在Nature Communications发表了题为“Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects”的研究论文,发现白喉酰胺生物合成1(diphthamide biosynthesis 1,DPH1)基因突变在儿童罕见病“发育迟缓、身材矮小和头发稀疏综合征”(developmental delay,short stature,and sparse hair syndrome,DEDSSH)中的致病机制,为DEDSSH及认知和发育障碍相关疾病的药物开发和治疗提供了新靶点。
