目的系统评价芪葵颗粒联合代谢控制治疗气阴两虚、湿瘀阻络型糖尿病性肾病(DN)的临床疗效。方法计算机检索中国知网期刊全文数据库、万方医药期刊数据库、维普中文科技期刊全文数据库及PubMed、Web of Science、ScienceDirect,搜索芪葵...目的系统评价芪葵颗粒联合代谢控制治疗气阴两虚、湿瘀阻络型糖尿病性肾病(DN)的临床疗效。方法计算机检索中国知网期刊全文数据库、万方医药期刊数据库、维普中文科技期刊全文数据库及PubMed、Web of Science、ScienceDirect,搜索芪葵颗粒治疗DN的随机对照研究,检索时间自建库至2022年3月。由两位研究者独立筛选文献、提取资料并评估纳入研究的偏倚风险后,采用Revman 5.4.1软件进行分析。结果共纳入9项随机对照研究,638例DN患者,涉及主要疗效指标五项。Meta分析结果显示:降尿蛋白有效率[RR=0.72,95%CI(0.64,0.80),P<0.00001]、UACR[WMD=12.54,95%CI(2.40,22.67),P=0.02]、BUN[WMD=0.67,95%CI(0.53,0.80),P<0.00001]、24h-UTP[WMD=25.26,95%CI(17.30,33.23),P<0.00001]、Scr[WMD=3.92,95%CI(2.61,5.24),P<0.00001]等疗效指标均优于对照组,其差异具有统计学意义。结论根据目前临床证据表明,芪葵颗粒治疗DN有显著疗效。展开更多
OBJECTIVE To observe the effect of Qi Kwai Granule particles on the expression of in.terleukin 6(IL-6),monocyte chemotactic protein 1(MCP-1) and transforming growth factor-β1(TGF-β1)in diabetic nephropathy(DN) rats ...OBJECTIVE To observe the effect of Qi Kwai Granule particles on the expression of in.terleukin 6(IL-6),monocyte chemotactic protein 1(MCP-1) and transforming growth factor-β1(TGF-β1)in diabetic nephropathy(DN) rats and evaluate the protective effect of Qi Kwai Granule particles against renal injury of diabetic nephropathy.METHODS This experiment adopts adopted the high-sugar-highfat diet and intraperitoneal injection of 2% STZ+ unilateral renal ligation to establish rat model of diabet.ic nephropathy.50 model rats were then randomly divided into model group,Irbesartan group,Qi Kwai Granule particles of high,medium,low dose group,10 rats in each group.10 normal rats were set as the sham operation group.Intragastric administration for 8 weeks were measured in rats.Measure the value of rat blood glucose by blood glucose meter,the determination of serum interleukin 6(IL-6) con.tent by ELISA,the expression of MCP-1 and TGF-β1 by immunohistochemistry method.The value of rat blood glucose were measured by blood glucose meter.Serum interleukin 6(IL-6) were determinat.ed by ELISA.Expression of MCP-1 and TGF-β1 were evaluated by immunohistochemistry method.RE.SULTS The blood glucose of Qi Kwai Granule particles of high,medium groups were decreased com.pared with those of the model group(P<0.05).The content of IL-6 of Qi Kwai Granule particles of high,medium groups were reduced(P<0.01).The content of MCP-1,TGF-β1 in kidney of Qi Kwai Granule particles of high,medium,low dose groups were decreased(P<0.01).CONCLUSION Qi Kwai parti.cles have protective effect on renal tissue of diabetic nephropathy rats.Its mechanism might be related to the decrease of blood glucose value and IL-6,the inhibition of the expression of MCP-1 and TGF-β1.展开更多
文摘目的系统评价芪葵颗粒联合代谢控制治疗气阴两虚、湿瘀阻络型糖尿病性肾病(DN)的临床疗效。方法计算机检索中国知网期刊全文数据库、万方医药期刊数据库、维普中文科技期刊全文数据库及PubMed、Web of Science、ScienceDirect,搜索芪葵颗粒治疗DN的随机对照研究,检索时间自建库至2022年3月。由两位研究者独立筛选文献、提取资料并评估纳入研究的偏倚风险后,采用Revman 5.4.1软件进行分析。结果共纳入9项随机对照研究,638例DN患者,涉及主要疗效指标五项。Meta分析结果显示:降尿蛋白有效率[RR=0.72,95%CI(0.64,0.80),P<0.00001]、UACR[WMD=12.54,95%CI(2.40,22.67),P=0.02]、BUN[WMD=0.67,95%CI(0.53,0.80),P<0.00001]、24h-UTP[WMD=25.26,95%CI(17.30,33.23),P<0.00001]、Scr[WMD=3.92,95%CI(2.61,5.24),P<0.00001]等疗效指标均优于对照组,其差异具有统计学意义。结论根据目前临床证据表明,芪葵颗粒治疗DN有显著疗效。
文摘OBJECTIVE To observe the effect of Qi Kwai Granule particles on the expression of in.terleukin 6(IL-6),monocyte chemotactic protein 1(MCP-1) and transforming growth factor-β1(TGF-β1)in diabetic nephropathy(DN) rats and evaluate the protective effect of Qi Kwai Granule particles against renal injury of diabetic nephropathy.METHODS This experiment adopts adopted the high-sugar-highfat diet and intraperitoneal injection of 2% STZ+ unilateral renal ligation to establish rat model of diabet.ic nephropathy.50 model rats were then randomly divided into model group,Irbesartan group,Qi Kwai Granule particles of high,medium,low dose group,10 rats in each group.10 normal rats were set as the sham operation group.Intragastric administration for 8 weeks were measured in rats.Measure the value of rat blood glucose by blood glucose meter,the determination of serum interleukin 6(IL-6) con.tent by ELISA,the expression of MCP-1 and TGF-β1 by immunohistochemistry method.The value of rat blood glucose were measured by blood glucose meter.Serum interleukin 6(IL-6) were determinat.ed by ELISA.Expression of MCP-1 and TGF-β1 were evaluated by immunohistochemistry method.RE.SULTS The blood glucose of Qi Kwai Granule particles of high,medium groups were decreased com.pared with those of the model group(P<0.05).The content of IL-6 of Qi Kwai Granule particles of high,medium groups were reduced(P<0.01).The content of MCP-1,TGF-β1 in kidney of Qi Kwai Granule particles of high,medium,low dose groups were decreased(P<0.01).CONCLUSION Qi Kwai parti.cles have protective effect on renal tissue of diabetic nephropathy rats.Its mechanism might be related to the decrease of blood glucose value and IL-6,the inhibition of the expression of MCP-1 and TGF-β1.
