目的比较脉搏血氧计连续无创法和血气分析法检测血红蛋白（Hb）的一致性。方法对69名择期全麻肝脏部分切除术患者，在术中同时采用连续无创法和血气分析法检测Hb，共获得164对数据。采用配对t检验，Bland-Altman分析方法和多元线性回归...目的比较脉搏血氧计连续无创法和血气分析法检测血红蛋白（Hb）的一致性。方法对69名择期全麻肝脏部分切除术患者，在术中同时采用连续无创法和血气分析法检测Hb，共获得164对数据。采用配对t检验，Bland-Altman分析方法和多元线性回归分析评估2种测量方法的一致性及可能的影响因素。结果连续无创法与血气分析法分别测得Hb（s／dL）为-12．7±1．9 vs 11．6±1.9（P〈0．05）；Bland—Altman方法分析2种测量方法的偏倚值为（1．1±2．8）g／dL；95％一致性界限为（-1．7～3．9）g／dL；多元线性回归分析提示使偏倚值发生明显变化（P〈0．05）的变量包括有创Hb浓度（tHb）、平均动脉压（MAP）和灌注指数（PI）。结论Masimo Radical-7脉搏血氧计倾向于高估Hb，其准确性易受外界因素的影响；但术中维持稳定的血流动力学能够保持其检测误差的稳定，因而在肝脏部分切除术中对指导输血仍具有一定的参考意义。展开更多
Guan-fu base A(GFA),a new antiarrhythmic alkaloid with a structure of C_(20)-diterpenoid could react rapidly and quantitatively with trifluoroacetic anhydride(TFAA) to produce GFA—TFAA of which the structure was iden...Guan-fu base A(GFA),a new antiarrhythmic alkaloid with a structure of C_(20)-diterpenoid could react rapidly and quantitatively with trifluoroacetic anhydride(TFAA) to produce GFA—TFAA of which the structure was identified by GC—MSD.There was a wide linear range of the GC-ECD method from 10 to 20000ng/ml(r=0.9984).The average recovery of GFA from the spiked plasma was 97.52%.The coefficients of variation of within-day and between-day were less than 7% and 9%,respectively.The method was used in the preclinical experiment of pharmacology of GFA and the results showed that GFA con- centrations in rabbits' plasma within 6 hours after the administration ranged from 0.338± 0.014 to 13.459±5.393μg/ml for dosage 10mg/kg,from 0.133±0.038 to 2.546±0.480 μg/ml for dosage 2mg/kg and from 45.25±10.34 to 535.86±24.36ng/ml for dosage 0.4 mg/kg.展开更多
文摘目的比较脉搏血氧计连续无创法和血气分析法检测血红蛋白（Hb）的一致性。方法对69名择期全麻肝脏部分切除术患者，在术中同时采用连续无创法和血气分析法检测Hb，共获得164对数据。采用配对t检验，Bland-Altman分析方法和多元线性回归分析评估2种测量方法的一致性及可能的影响因素。结果连续无创法与血气分析法分别测得Hb（s／dL）为-12．7±1．9 vs 11．6±1.9（P〈0．05）；Bland—Altman方法分析2种测量方法的偏倚值为（1．1±2．8）g／dL；95％一致性界限为（-1．7～3．9）g／dL；多元线性回归分析提示使偏倚值发生明显变化（P〈0．05）的变量包括有创Hb浓度（tHb）、平均动脉压（MAP）和灌注指数（PI）。结论Masimo Radical-7脉搏血氧计倾向于高估Hb，其准确性易受外界因素的影响；但术中维持稳定的血流动力学能够保持其检测误差的稳定，因而在肝脏部分切除术中对指导输血仍具有一定的参考意义。
文摘Guan-fu base A(GFA),a new antiarrhythmic alkaloid with a structure of C_(20)-diterpenoid could react rapidly and quantitatively with trifluoroacetic anhydride(TFAA) to produce GFA—TFAA of which the structure was identified by GC—MSD.There was a wide linear range of the GC-ECD method from 10 to 20000ng/ml(r=0.9984).The average recovery of GFA from the spiked plasma was 97.52%.The coefficients of variation of within-day and between-day were less than 7% and 9%,respectively.The method was used in the preclinical experiment of pharmacology of GFA and the results showed that GFA con- centrations in rabbits' plasma within 6 hours after the administration ranged from 0.338± 0.014 to 13.459±5.393μg/ml for dosage 10mg/kg,from 0.133±0.038 to 2.546±0.480 μg/ml for dosage 2mg/kg and from 45.25±10.34 to 535.86±24.36ng/ml for dosage 0.4 mg/kg.
