目的探讨黄芩茎叶总黄酮（Total flavonolds from stems and leaves of Seutellaria baiealensis Georgi，TF）抑制角叉菜胶诱发小鼠尾部血栓形成。方法50mg／kg角叉菜胶皮下注射诱发小鼠尾部血栓形成，通过24，48，72h小鼠血栓发生率...目的探讨黄芩茎叶总黄酮（Total flavonolds from stems and leaves of Seutellaria baiealensis Georgi，TF）抑制角叉菜胶诱发小鼠尾部血栓形成。方法50mg／kg角叉菜胶皮下注射诱发小鼠尾部血栓形成，通过24，48，72h小鼠血栓发生率、黑尾长度以及凝血时间的测定，确定TP对角叉菜胶诱发小鼠血栓形成的影响。结果50～200mg／kgTP不同程度降低角叉菜胶引起小鼠尾部血栓发生率，缩短血栓长度和延长凝血时间。结论TP能抑制角叉菜胶引起小鼠尾部血栓形成。展开更多
The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord...The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord following intraplantar injecti on of ca rrageenan. In vivo microdialysis and high performance liquid chromatography wit h electrochemical detection were performed. The results showed that intraplantar injection of carrageenan significantly increased dopamine or homovanillic acid l evels in the different central regions. The present study suggested that the cen tral dopamine system (at least including ascending nigrostriatal pathway and des cending A 11 --the dorsal horn fibers) could be activated following intrap lantar injection of carrageenan, while the resultant activation probably mediate d antinociception.展开更多
文摘目的探讨黄芩茎叶总黄酮（Total flavonolds from stems and leaves of Seutellaria baiealensis Georgi，TF）抑制角叉菜胶诱发小鼠尾部血栓形成。方法50mg／kg角叉菜胶皮下注射诱发小鼠尾部血栓形成，通过24，48，72h小鼠血栓发生率、黑尾长度以及凝血时间的测定，确定TP对角叉菜胶诱发小鼠血栓形成的影响。结果50～200mg／kgTP不同程度降低角叉菜胶引起小鼠尾部血栓发生率，缩短血栓长度和延长凝血时间。结论TP能抑制角叉菜胶引起小鼠尾部血栓形成。
文摘The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord following intraplantar injecti on of ca rrageenan. In vivo microdialysis and high performance liquid chromatography wit h electrochemical detection were performed. The results showed that intraplantar injection of carrageenan significantly increased dopamine or homovanillic acid l evels in the different central regions. The present study suggested that the cen tral dopamine system (at least including ascending nigrostriatal pathway and des cending A 11 --the dorsal horn fibers) could be activated following intrap lantar injection of carrageenan, while the resultant activation probably mediate d antinociception.
