目的考察川芎和香附超临界 CO2提取物及其水凝胶贴剂的体外经皮透过性。方法实验采用 Franz 扩散装置,分别以藁本内酯和α-香附酮为川芎和香附提取物的指标成分,考察提取物及其水凝胶贴剂经离体大鼠皮肤的透过性。结果川芎和香附超临界 ...目的考察川芎和香附超临界 CO2提取物及其水凝胶贴剂的体外经皮透过性。方法实验采用 Franz 扩散装置,分别以藁本内酯和α-香附酮为川芎和香附提取物的指标成分,考察提取物及其水凝胶贴剂经离体大鼠皮肤的透过性。结果川芎和香附超临界 CO2 提取物中的多种成分均具有经皮透过性,提取物的比例不同对指标成分的经皮透过性无明显影响。结论经皮给药可望作为川芎和香附超临界 CO2提取物的一种新的给药途径。展开更多
OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercriti...OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercritical fluid extraction(SFE) with CO 2,and the constituents of the volatile oil extracts were analyzed by gas chromatography-mass spectrometry(GC-MS).The relative content of each component was calculated using peak area normalization.RESULTS:The optimized SFE conditions were 45 MPa at 35℃ for 2 h.Twenty-four compounds were identified in the extract from the Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) mixture,and six of these had relative contents >1.These compounds were 1,2-dimethoxy-4-(2-propenyl)-benzene;1,2,3-trimethoxy-5-(2-propenyl)-benzene;β-asarone;(Z,Z) 9,12-octadecadienoic acid;(Z) 6-octadecenoic acid;and ethyl oleate.Combination of the herbs increased the number of pharmacologically active substances in the extract and decreased the number of compounds with one benzene ring compared with the extracts from the individual herbs.CONCLUSION:These results indicate there is a synergistic relationship among the compounds in these herbs.展开更多
文摘目的考察川芎和香附超临界 CO2提取物及其水凝胶贴剂的体外经皮透过性。方法实验采用 Franz 扩散装置,分别以藁本内酯和α-香附酮为川芎和香附提取物的指标成分,考察提取物及其水凝胶贴剂经离体大鼠皮肤的透过性。结果川芎和香附超临界 CO2 提取物中的多种成分均具有经皮透过性,提取物的比例不同对指标成分的经皮透过性无明显影响。结论经皮给药可望作为川芎和香附超临界 CO2提取物的一种新的给药途径。
基金Supported by Shanxi Science and Technology Tackling Fund(No.20100311090)Shanxi Provincial Health Department Science and Technology Tackling Fund (No.2008034)
文摘OBJECTIVE:To analyze the constituents of volatile oils extracted from Yuan Zhi(Radix Polygalae),Shi Chang Pu(Acorus Tatarinowii),and a mixture of the two herbs.METHODS:The volatile oils were extracted using supercritical fluid extraction(SFE) with CO 2,and the constituents of the volatile oil extracts were analyzed by gas chromatography-mass spectrometry(GC-MS).The relative content of each component was calculated using peak area normalization.RESULTS:The optimized SFE conditions were 45 MPa at 35℃ for 2 h.Twenty-four compounds were identified in the extract from the Yuan Zhi(Radix Polygalae) and Shi Chang Pu(Acorus Tatarinowii) mixture,and six of these had relative contents >1.These compounds were 1,2-dimethoxy-4-(2-propenyl)-benzene;1,2,3-trimethoxy-5-(2-propenyl)-benzene;β-asarone;(Z,Z) 9,12-octadecadienoic acid;(Z) 6-octadecenoic acid;and ethyl oleate.Combination of the herbs increased the number of pharmacologically active substances in the extract and decreased the number of compounds with one benzene ring compared with the extracts from the individual herbs.CONCLUSION:These results indicate there is a synergistic relationship among the compounds in these herbs.
