Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine ...Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Design: Prospective and retrospective observational study. Setting: Dermatology outpatient clinic in a general hospital. Patients: Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. Interventions: None. Main Outcome Measures: Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. Results: HLA-DR4 (DRB1.0404) was significantly increased (P < .001; odds ratio, 3.9; 95%confidence interval, 1.86-8.03)-. Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. Conclusions: The HLA-DRB1.0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.展开更多
目的探讨按压法治疗对过度增生肉芽的抑制效果及对伤口愈合的影响。方法选取2017年10月至2020年10月因肉芽过度增生、导致伤口迁延不愈合的患者46例,进行自身对照研究;其中男28例,女18例;中位年龄48岁;将同一患者的伤口分成对照组和观察...目的探讨按压法治疗对过度增生肉芽的抑制效果及对伤口愈合的影响。方法选取2017年10月至2020年10月因肉芽过度增生、导致伤口迁延不愈合的患者46例,进行自身对照研究;其中男28例,女18例;中位年龄48岁;将同一患者的伤口分成对照组和观察组,对照组运用湿性愈合理念治疗;观察组在对照组治疗的基础上,增加按压疗法,即结合持续或间断的按压模式,利用患者或家属的手指或掌部力量,对过度增生肉芽伤口进行按压,一般压力为20~30 mm Hg;根据伤口的动态变化,及时调整伤口处理方法,以达到换药时患者无痛,并促进伤口愈合的效果。结果3个月后评价,观察组在伤口换药间隔时间[(54.85±11.27)h vs(50.17±10.90)h]、愈合时间[(27.39±11.04)d vs(32.15±11.78)d]、瘢痕评分[(2.09±1.26)分vs(2.80±1.33)分]方面,均优于对照组(P<0.05)。结论运用按压法治疗肉芽过度增生伤口,在执行过程中,简单可行、安全、经济、无痛,同时贯穿多种灵活的换药方式及全程的健康宣教,患者及家属易接受,依从性良好,伤口愈合效果满意。展开更多
文摘Objectives: To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Design: Prospective and retrospective observational study. Setting: Dermatology outpatient clinic in a general hospital. Patients: Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. Interventions: None. Main Outcome Measures: Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. Results: HLA-DR4 (DRB1.0404) was significantly increased (P < .001; odds ratio, 3.9; 95%confidence interval, 1.86-8.03)-. Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. Conclusions: The HLA-DRB1.0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
文摘目的探讨按压法治疗对过度增生肉芽的抑制效果及对伤口愈合的影响。方法选取2017年10月至2020年10月因肉芽过度增生、导致伤口迁延不愈合的患者46例,进行自身对照研究;其中男28例,女18例;中位年龄48岁;将同一患者的伤口分成对照组和观察组,对照组运用湿性愈合理念治疗;观察组在对照组治疗的基础上,增加按压疗法,即结合持续或间断的按压模式,利用患者或家属的手指或掌部力量,对过度增生肉芽伤口进行按压,一般压力为20~30 mm Hg;根据伤口的动态变化,及时调整伤口处理方法,以达到换药时患者无痛,并促进伤口愈合的效果。结果3个月后评价,观察组在伤口换药间隔时间[(54.85±11.27)h vs(50.17±10.90)h]、愈合时间[(27.39±11.04)d vs(32.15±11.78)d]、瘢痕评分[(2.09±1.26)分vs(2.80±1.33)分]方面,均优于对照组(P<0.05)。结论运用按压法治疗肉芽过度增生伤口,在执行过程中,简单可行、安全、经济、无痛,同时贯穿多种灵活的换药方式及全程的健康宣教,患者及家属易接受,依从性良好,伤口愈合效果满意。
