Background: Although psoriasis vulgaris (PV) is strongly associated with HLA Cw 0602, it has been proposed that the association of Cw 0602 is due to linkage disequilibrium and that other nearby genes are involved in P...Background: Although psoriasis vulgaris (PV) is strongly associated with HLA Cw 0602, it has been proposed that the association of Cw 0602 is due to linkage disequilibrium and that other nearby genes are involved in PV susceptibility The α helix coiled coil rod homologue (HCR) gene, located 110 kb telomeric to the HLA C locus, is presumed to be one of the PV candidate genes Recently, a 10 kb genomic segment, centromeric to HLA C, defined by two new single nucleotide polymorphisms (SNPs) n 7 A and n 9 C, was found to have a stronger association with psoriasis than the HCR gene Until now, no study of the association of the HCR gene, SNPs n 7, and n 9 has been conducted on Chinese patients with psoriasis Objectives: We aimed to determine whether the genetic polymorphisms of the HCR gene, SNPs n 7 A, and n 9 C were associated with an increased risk of psoriasis in Chinese patients Methods: Using direct sequencing of the HCR gene and the genomic region containing SNPs n 7 and n 9, we investigated the HCR gene, SNPs n 7, and n 9 for disease association in 115 Chinese patients with psoriasis and 103 control subjects The HCR SNPs were confirmed by denaturing high performance liquid chromatography Genotyping for HLA Cw 0602 was also carried out using sequence based typing Results: We observed a different allelic distribution between patient and control groups at nucleotide positions 386, 404, 1802 and 2406 of the HCR gene, and SNPs n 7, and n 9 The associations were much stronger in early onset PV patients (for HCR-386 T and HCR-404 T, odds ratio = 5 63, Pc < 0 0001) The HLA Cw 0602 also displayed a similar association with PV (odds ratio = 5 4, Pc < 0 0001) Moreover, SNP n 7 A, SNP n 9 C, Cw 0602, HCR-386 T, HCR-404 T and HCR-1802 T were in linkage disequilibrium with each other Haplotype based association analysis showed SNP n 7 A SNP n 9 C Cw 0602 HCR-386 T HCR-404 THCR-1802 T HCR-2406 G as a major susceptibility haplotype in this Chinese population (for early onset patients, odds ratio = 5 15, Pc < 0 0001) Conclusions: Our results indicate that the HCR gene, SNP n 7 A, and SNP n 9 C as well as Cw 0602 are major susceptibility markers for psoriasis in Chinese展开更多
The main causes of arteriopathy in young patients include drugs, metabolic diseases, pseudoxanthoma elasticum and Buerger’s disease. Arteritis due to Cannabis indica was first reported in 1960, and the role of this d...The main causes of arteriopathy in young patients include drugs, metabolic diseases, pseudoxanthoma elasticum and Buerger’s disease. Arteritis due to Cannabis indica was first reported in 1960, and the role of this drug as a risk factor for arteritis was confirmed in several subsequent publications. A 38- year-old smoker with no previous contributory medical history except for long-standing cannabis abuse developed a dry necrotic lesion of the left big toe. Imaging examinations revealed proximal arteriopathy of the lower limbs that predominated on the left side. He had no atherogenic or thrombogenic risk factors, and no signs of pseudoxanthoma elasticum were found. Remarkably, the development of arteritis paralleled cannabis abuse. The course was slowly favourable after weaning from the drug, vasodilator treatment and hyperbaric oxygen therapy. Despite some subtle clinical differences (more proximal than distal involvement), cannabis arteritis may be considered as a particular form of Buerger’s disease, where cannabis, along with tobacco, seems to cause arterial lesions. Along with the noxious effects of cannabis on vessels, a role for contaminating arsenic is also possible. Cannabis arteritis is not widely known, but may prove not to be so rare if one considers consumption of cannabis besides that of tobacco.展开更多
Background &Aims: Studies in health have shown that tension sensitive mechanoreceptors mediate sensitivity to gastric distention. A role for these mechanoreceptors in perception or symptoms in hypersensitive funct...Background &Aims: Studies in health have shown that tension sensitive mechanoreceptors mediate sensitivity to gastric distention. A role for these mechanoreceptors in perception or symptoms in hypersensitive functional dyspepsia (FD) has not been established. Tension sensitive mechanoreceptors are activated during phasic contractions and inactivated during gastric relaxation. The aim of the present study was to investigate whether hypersensitive FD patients perceive spontaneous changes in fundic wall tension and whether fundus relaxing drugs decrease sensitivity to gastric distention and meal related symptoms. Methods: Fifty patients were selected after a barostat study established gastric hypersensitivity. In 12 patients, an intragastric balloon was inflated with a fixed volume just below perception thresholds and patients were asked to indicate changes in perception on a keypad, and the relationship between perception and contractions was analyzed. In 20 patients, we studied the influence of the fundus relaxing drug sumatriptan on sensitivity to gastric distention. In, respectively, 10 and 8 patients, we studied the influence of the fundus relaxing drugs sumatriptan and clonidine on meal related symptoms. Results: The majority of patients had a statistically significant association between perception and phasic isovolumetric contractions. Pretreatment with sumatriptan increased both pressures and volumes needed to induce first perception and discomfort. Pretreatment with sumatriptan and clonidine both significantly decreased meal induced symptoms. Conclusions: Patients with hypersensitivity to gastric distention perceive isovolumetric phasic contractions of the proximal stomach. Fundus relaxing drugs decrease sensitivity to gastric distention and decrease meal induced symptoms in these patients. The findings are compatible with involvement of tension mechanoreceptors in symptom generation in hypersensitive FD.展开更多
Background and Study Aim: Ensdoscopic ultrasound- gui- ded fine- needle aspiration (EUS- FNA) has been reported as a useful techni que for histological diagnosis of submucosal or extrinsic gastrointestinal and p ancre...Background and Study Aim: Ensdoscopic ultrasound- gui- ded fine- needle aspiration (EUS- FNA) has been reported as a useful techni que for histological diagnosis of submucosal or extrinsic gastrointestinal and p ancreatic lesions. The aim of this study was to evaluate the use of EUS- FNA fo r the diagnosis of lesions either within or adjacent to the wall of the colon an d rectum. Patients and Methods: A total of 22 patients with a lesion within the wall of, or adjacent to, the colon or rectum underwent EUS- FNA. They were divi ded into two groups: patients who had previously had a malignancy (the “ previo us + ve" group, n=11), and patients who had not previously had a malignancy (th e “ previous - ve" group, n = 11). In the four patients who had lesions locate d proximal to the sigmoid colon, EUS- FNA was performed using a guide wire and overtube. The success rates for adequate tissue sampling and for detecting malig nant and benign masses by EUS- FNA were evaluated and the success rate for dete ction was compared with the success rate of EUS and computed tomography. Results : Sufficient tissue for evaluation was obtained from 21 of be 22 patients (95.5 % ). The overall rate of detection of malignant and benign masses was 95.5% ( 21/22) for EUS- FNA and 81.8% (18/22) for pre- EUS- FNA imaging investigati ons. Of the 11 patients in the previous + ve group, ten were diagnosed with recurrences of primary malignancies; of the 11 patients in the previous - ve group, four we re diagnosed with primary malignancies and seven were diagnosed with benign lesi ons. There were no complications related to the EUS- FNA procedure. Conclusions : EUS- FNA is a safe techniquewhich is useful in the planning of treatment for patients who have a mass within the wall or adjacent to the wall of the entire l ength of the colon or rectum.展开更多
文摘Background: Although psoriasis vulgaris (PV) is strongly associated with HLA Cw 0602, it has been proposed that the association of Cw 0602 is due to linkage disequilibrium and that other nearby genes are involved in PV susceptibility The α helix coiled coil rod homologue (HCR) gene, located 110 kb telomeric to the HLA C locus, is presumed to be one of the PV candidate genes Recently, a 10 kb genomic segment, centromeric to HLA C, defined by two new single nucleotide polymorphisms (SNPs) n 7 A and n 9 C, was found to have a stronger association with psoriasis than the HCR gene Until now, no study of the association of the HCR gene, SNPs n 7, and n 9 has been conducted on Chinese patients with psoriasis Objectives: We aimed to determine whether the genetic polymorphisms of the HCR gene, SNPs n 7 A, and n 9 C were associated with an increased risk of psoriasis in Chinese patients Methods: Using direct sequencing of the HCR gene and the genomic region containing SNPs n 7 and n 9, we investigated the HCR gene, SNPs n 7, and n 9 for disease association in 115 Chinese patients with psoriasis and 103 control subjects The HCR SNPs were confirmed by denaturing high performance liquid chromatography Genotyping for HLA Cw 0602 was also carried out using sequence based typing Results: We observed a different allelic distribution between patient and control groups at nucleotide positions 386, 404, 1802 and 2406 of the HCR gene, and SNPs n 7, and n 9 The associations were much stronger in early onset PV patients (for HCR-386 T and HCR-404 T, odds ratio = 5 63, Pc < 0 0001) The HLA Cw 0602 also displayed a similar association with PV (odds ratio = 5 4, Pc < 0 0001) Moreover, SNP n 7 A, SNP n 9 C, Cw 0602, HCR-386 T, HCR-404 T and HCR-1802 T were in linkage disequilibrium with each other Haplotype based association analysis showed SNP n 7 A SNP n 9 C Cw 0602 HCR-386 T HCR-404 THCR-1802 T HCR-2406 G as a major susceptibility haplotype in this Chinese population (for early onset patients, odds ratio = 5 15, Pc < 0 0001) Conclusions: Our results indicate that the HCR gene, SNP n 7 A, and SNP n 9 C as well as Cw 0602 are major susceptibility markers for psoriasis in Chinese
文摘The main causes of arteriopathy in young patients include drugs, metabolic diseases, pseudoxanthoma elasticum and Buerger’s disease. Arteritis due to Cannabis indica was first reported in 1960, and the role of this drug as a risk factor for arteritis was confirmed in several subsequent publications. A 38- year-old smoker with no previous contributory medical history except for long-standing cannabis abuse developed a dry necrotic lesion of the left big toe. Imaging examinations revealed proximal arteriopathy of the lower limbs that predominated on the left side. He had no atherogenic or thrombogenic risk factors, and no signs of pseudoxanthoma elasticum were found. Remarkably, the development of arteritis paralleled cannabis abuse. The course was slowly favourable after weaning from the drug, vasodilator treatment and hyperbaric oxygen therapy. Despite some subtle clinical differences (more proximal than distal involvement), cannabis arteritis may be considered as a particular form of Buerger’s disease, where cannabis, along with tobacco, seems to cause arterial lesions. Along with the noxious effects of cannabis on vessels, a role for contaminating arsenic is also possible. Cannabis arteritis is not widely known, but may prove not to be so rare if one considers consumption of cannabis besides that of tobacco.
文摘Background &Aims: Studies in health have shown that tension sensitive mechanoreceptors mediate sensitivity to gastric distention. A role for these mechanoreceptors in perception or symptoms in hypersensitive functional dyspepsia (FD) has not been established. Tension sensitive mechanoreceptors are activated during phasic contractions and inactivated during gastric relaxation. The aim of the present study was to investigate whether hypersensitive FD patients perceive spontaneous changes in fundic wall tension and whether fundus relaxing drugs decrease sensitivity to gastric distention and meal related symptoms. Methods: Fifty patients were selected after a barostat study established gastric hypersensitivity. In 12 patients, an intragastric balloon was inflated with a fixed volume just below perception thresholds and patients were asked to indicate changes in perception on a keypad, and the relationship between perception and contractions was analyzed. In 20 patients, we studied the influence of the fundus relaxing drug sumatriptan on sensitivity to gastric distention. In, respectively, 10 and 8 patients, we studied the influence of the fundus relaxing drugs sumatriptan and clonidine on meal related symptoms. Results: The majority of patients had a statistically significant association between perception and phasic isovolumetric contractions. Pretreatment with sumatriptan increased both pressures and volumes needed to induce first perception and discomfort. Pretreatment with sumatriptan and clonidine both significantly decreased meal induced symptoms. Conclusions: Patients with hypersensitivity to gastric distention perceive isovolumetric phasic contractions of the proximal stomach. Fundus relaxing drugs decrease sensitivity to gastric distention and decrease meal induced symptoms in these patients. The findings are compatible with involvement of tension mechanoreceptors in symptom generation in hypersensitive FD.
文摘Background and Study Aim: Ensdoscopic ultrasound- gui- ded fine- needle aspiration (EUS- FNA) has been reported as a useful techni que for histological diagnosis of submucosal or extrinsic gastrointestinal and p ancreatic lesions. The aim of this study was to evaluate the use of EUS- FNA fo r the diagnosis of lesions either within or adjacent to the wall of the colon an d rectum. Patients and Methods: A total of 22 patients with a lesion within the wall of, or adjacent to, the colon or rectum underwent EUS- FNA. They were divi ded into two groups: patients who had previously had a malignancy (the “ previo us + ve" group, n=11), and patients who had not previously had a malignancy (th e “ previous - ve" group, n = 11). In the four patients who had lesions locate d proximal to the sigmoid colon, EUS- FNA was performed using a guide wire and overtube. The success rates for adequate tissue sampling and for detecting malig nant and benign masses by EUS- FNA were evaluated and the success rate for dete ction was compared with the success rate of EUS and computed tomography. Results : Sufficient tissue for evaluation was obtained from 21 of be 22 patients (95.5 % ). The overall rate of detection of malignant and benign masses was 95.5% ( 21/22) for EUS- FNA and 81.8% (18/22) for pre- EUS- FNA imaging investigati ons. Of the 11 patients in the previous + ve group, ten were diagnosed with recurrences of primary malignancies; of the 11 patients in the previous - ve group, four we re diagnosed with primary malignancies and seven were diagnosed with benign lesi ons. There were no complications related to the EUS- FNA procedure. Conclusions : EUS- FNA is a safe techniquewhich is useful in the planning of treatment for patients who have a mass within the wall or adjacent to the wall of the entire l ength of the colon or rectum.
