Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as bioch...Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.展开更多
The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can ...The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can play a major role in this process,because selective mating is often mediated by sexual signals: bright colours, complex song, pheromone blends and so on. Whendivergent sensory adaptation affects the perception of such signals, mating patterns may change as an immediate consequence.Alternatively, mating preferences can diverge as a result of indirect effects: assortative mating may be promoted by selectionagainst intermediate phenotypes that are maladapted to their (sensory) environment. For Lake Victoria cichlids, the visual environmentconstitutes an important selective force that is heterogeneous across geographical and water depth gradients. We investigatethe direct and indirect effects of this heterogeneity on the evolution of female preferences for alternative male nuptial colours(red and blue) in the genus Pundamilia. Here, we review the current evidence for divergent sensory drive in this system, extractgeneral principles, and discuss future perspectives [Current Zoology 56 (3): 285-299, 2010].展开更多
IEEE 802.16 systems adopt a "semi-dynamic" allocation mechanism of channel quality indicator (CQI) channels.However,low utilization ratio of CQI channels reduces the spectrum efficiency.So we propose an adap...IEEE 802.16 systems adopt a "semi-dynamic" allocation mechanism of channel quality indicator (CQI) channels.However,low utilization ratio of CQI channels reduces the spectrum efficiency.So we propose an adaptive management strategy of CQI channels based on an analysis model named "toy brick model" to improve the efficiency.The simulation results validate the improvement.展开更多
文摘Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.
基金funded by the Swiss National Science Foundation (SNSF)the Netherlands Foundation for Scientific Research (NWO-ALW and NWO-WOTRO)
文摘The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can play a major role in this process,because selective mating is often mediated by sexual signals: bright colours, complex song, pheromone blends and so on. Whendivergent sensory adaptation affects the perception of such signals, mating patterns may change as an immediate consequence.Alternatively, mating preferences can diverge as a result of indirect effects: assortative mating may be promoted by selectionagainst intermediate phenotypes that are maladapted to their (sensory) environment. For Lake Victoria cichlids, the visual environmentconstitutes an important selective force that is heterogeneous across geographical and water depth gradients. We investigatethe direct and indirect effects of this heterogeneity on the evolution of female preferences for alternative male nuptial colours(red and blue) in the genus Pundamilia. Here, we review the current evidence for divergent sensory drive in this system, extractgeneral principles, and discuss future perspectives [Current Zoology 56 (3): 285-299, 2010].
基金National High Technology Research and Development Program of China(No.2006AA01Z235)
文摘IEEE 802.16 systems adopt a "semi-dynamic" allocation mechanism of channel quality indicator (CQI) channels.However,low utilization ratio of CQI channels reduces the spectrum efficiency.So we propose an adaptive management strategy of CQI channels based on an analysis model named "toy brick model" to improve the efficiency.The simulation results validate the improvement.
