Hematopoietic stem cell (HSC) engraftment is delayed in children with hypersplenism, and splenectomy may improve HSC engraftment. However, the use of total splenectomy in children is limited because of concerns for po...Hematopoietic stem cell (HSC) engraftment is delayed in children with hypersplenism, and splenectomy may improve HSC engraftment. However, the use of total splenectomy in children is limited because of concerns for postsplenectomy sepsis. In this study, the authors sought to assess the role of partial splenectomy for children with hypersplenism undergoing HSC transplantation. Five children with a variety of conditions and associated hypersplenism underwent partial splenectomy before an HSC transplantation at the authors’institution between 2000 and 2003. Primary outcome measures were rates of neutrophil and platelet engraftment. Secondary outcome measures included perioperative complications, splenic regrowth, graft-versus-host disease, and infection rate. All outcomes were compared with recipients of an HSC transplant from both age-matched nonsplenectomized children (n = 497) and hypersplenic children who underwent total splenectomy (n = 10). Outcomes were compared using Wilcoxon’s rank sum test. The rate of both neutrophil and platelet engraftment was faster in children who underwent either partial or total splenectomy as compared with nonsplenectomized children (mean rates of neutrophil engraftment were 26, 19, and 19 days for the nonsplenectomy, total splenectomy, and partial splenectomy groups, respectively; mean rates of platelet engraftment were 97, 37, and 45 days for the nonsplenectomy, total splenectomy, and partial splenectomy groups, respectively). Graft-versushost disease rates were similar between the 3 groups. The mean percentage of splenic regrowth after partial splenectomy was 39%. There were no perioperative complications. Partial splenectomy may be safely performed before HSC transplantation and, similar to total splenectomy, may improve the rate of HSC engraftment. Although this series has a limited number of patients, the use of partial splenectomy appears to be safe and may allow for splenic salvage to minimize the risk of postsplenectomy sepsis.展开更多
目的：探讨精准理念在腹腔镜部分脾切除术中的应用。方法回顾性分析6例精准腹腔镜部分脾切除术患者的临床资料。结果6例患者手术均顺利完成。其中，行脾上极切除术1例，脾下极切除术4例，半脾切除术1例。手术时间108～166 min ，术中出...目的：探讨精准理念在腹腔镜部分脾切除术中的应用。方法回顾性分析6例精准腹腔镜部分脾切除术患者的临床资料。结果6例患者手术均顺利完成。其中，行脾上极切除术1例，脾下极切除术4例，半脾切除术1例。手术时间108～166 min ，术中出血量120～650 ml。住院时间7～10 d。术后引流管拔除时间3～6（4.2±1.6） d；术后72 h内停用抗生素，无并发症出现。结论精准腹腔镜部分脾切除术可以保留脾脏功能，是一种安全且效果良好的手术。展开更多
文摘Hematopoietic stem cell (HSC) engraftment is delayed in children with hypersplenism, and splenectomy may improve HSC engraftment. However, the use of total splenectomy in children is limited because of concerns for postsplenectomy sepsis. In this study, the authors sought to assess the role of partial splenectomy for children with hypersplenism undergoing HSC transplantation. Five children with a variety of conditions and associated hypersplenism underwent partial splenectomy before an HSC transplantation at the authors’institution between 2000 and 2003. Primary outcome measures were rates of neutrophil and platelet engraftment. Secondary outcome measures included perioperative complications, splenic regrowth, graft-versus-host disease, and infection rate. All outcomes were compared with recipients of an HSC transplant from both age-matched nonsplenectomized children (n = 497) and hypersplenic children who underwent total splenectomy (n = 10). Outcomes were compared using Wilcoxon’s rank sum test. The rate of both neutrophil and platelet engraftment was faster in children who underwent either partial or total splenectomy as compared with nonsplenectomized children (mean rates of neutrophil engraftment were 26, 19, and 19 days for the nonsplenectomy, total splenectomy, and partial splenectomy groups, respectively; mean rates of platelet engraftment were 97, 37, and 45 days for the nonsplenectomy, total splenectomy, and partial splenectomy groups, respectively). Graft-versushost disease rates were similar between the 3 groups. The mean percentage of splenic regrowth after partial splenectomy was 39%. There were no perioperative complications. Partial splenectomy may be safely performed before HSC transplantation and, similar to total splenectomy, may improve the rate of HSC engraftment. Although this series has a limited number of patients, the use of partial splenectomy appears to be safe and may allow for splenic salvage to minimize the risk of postsplenectomy sepsis.
文摘目的评估腹腔镜脾部分切除术(laparoscopic partial splenectomy,LPS)在脾良性占位性病变手术治疗中的效果及安全性。方法分析华中科技大学同济医学院附属协和医院自2018年1月至2023年7月收治的85例脾良性占位性病变病人的临床资料,根据手术方式分为两组,25例行LPS的病人为LPS组,60例行腹腔镜全脾切除术(laparoscopic total splenectomy,LTS)的病人为LTS组。统计比较两组术前、术中、术后指标以及并发症(腹腔积液、感染、静脉血栓形成、血小板增多症等)发生率。结果两组病人均顺利完成手术。LPS组与LTS组比较,术后引流时间[(4.6±1.6)d比(5.9±1.6)d]、术后通气时间[(1.4±0.5)d比(1.9±0.8)d]、术后活动时间[(2.6±0.5)d比(3.1±0.8)d]及术后住院时间[(6.3±1.5)d比(7.8±3.1)d]均缩短,且术后第1、3天白细胞计数[(10.2±2.1)×10^(9)/L比(14.7±4.1)×10^(9)/L、(9.5±3.3)×10^(9)/L比(13.3±3.8)×10^(9)/L]及术后第1、3天血小板计数[(172.8±57.9)×10^(9)/L比(203.0±61.3)×10^(9)/L、(210.1±112.5)×10^(9)/L比(298.0±125.9)×10^(9)/L]LPS组均低于LTS组,差异均有统计学意义(均P<0.05);但两组的手术时间、术中出血量、术后引流量、红细胞计数、血红蛋白水平及白蛋白水平比较差异均无统计学意义(均P>0.05)。此外,LPS组术后并发症发生率显著低于LTS组[4.0%(1/25)比30.0%(18/60)],差异有统计学意义(χ^(2)=5.457,P<0.05)。结论LPS是一种疗效确切、安全可行的手术方式,在脾良性占位性病变的临床诊疗中具有重要价值,建议在有条件的医疗中心进行推广。
