4-Acylated or 3,4-diacylated caffeic acid phenethyl ester （CAPE） was prepared as prodrug to improve its stability and lipid solubility. Their neuroprotective activities were assessed by H202 model and 6-OHDA model. ...4-Acylated or 3,4-diacylated caffeic acid phenethyl ester （CAPE） was prepared as prodrug to improve its stability and lipid solubility. Their neuroprotective activities were assessed by H202 model and 6-OHDA model. The results showed that target compounds displayed positive abilities to protect PC 12 nerve cells from oxidative stress injury, superior to that of CAPE. Additionally, target compounds showed high blood-brain barrier permeability.展开更多
A new kind of intermolecular indole C–H amidation reaction catalyzed by the most frequently used palladium catalyst has been developed.Sulfonyl azide was employed as an innovative nitrogen source and environmentally ...A new kind of intermolecular indole C–H amidation reaction catalyzed by the most frequently used palladium catalyst has been developed.Sulfonyl azide was employed as an innovative nitrogen source and environmentally benign nitrogen was produced as the only byproduct.展开更多
基金National Natural Science Foundation of China(Grant No.201310061931.8)
文摘4-Acylated or 3,4-diacylated caffeic acid phenethyl ester （CAPE） was prepared as prodrug to improve its stability and lipid solubility. Their neuroprotective activities were assessed by H202 model and 6-OHDA model. The results showed that target compounds displayed positive abilities to protect PC 12 nerve cells from oxidative stress injury, superior to that of CAPE. Additionally, target compounds showed high blood-brain barrier permeability.
基金financially supported by the National Natural Science Foundation of China(21272233,21472190,21402203)
文摘A new kind of intermolecular indole C–H amidation reaction catalyzed by the most frequently used palladium catalyst has been developed.Sulfonyl azide was employed as an innovative nitrogen source and environmentally benign nitrogen was produced as the only byproduct.
