目的:分析自体富血小板血浆(PRP)联合重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶治疗下肢静脉性溃疡的临床效果。方法:选取2023年9月~2024年7月西京医院烧伤与皮肤外科门诊换药中心收治的90例下肢静脉性溃疡患者,采用随机数字表...目的:分析自体富血小板血浆(PRP)联合重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶治疗下肢静脉性溃疡的临床效果。方法:选取2023年9月~2024年7月西京医院烧伤与皮肤外科门诊换药中心收治的90例下肢静脉性溃疡患者,采用随机数字表法分为对照组和研究组,每组各45例。对照组采取常规的rhGM-CSF凝胶换药治疗,研究组在对照组基础上联合使用PRP治疗,分析比较两组疗效。结果:研究组总有效率91.1%,明显高于对照组68.8% (P 2/w,较对照组0.26 ± 0.06 cm2/w快(P P P Objective: To analyze the clinical effect of autologous platelet-rich plasma (PRP) combined with recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) gel in the treatment of venous lower extremity ulcers. Methods: A total of 90 patients with venous lower extremity ulcers admitted to the Outpatient Dressing Center of the Department of Burn and Dermatology Surgery of Xijing Hospital from September 2023 to July 2024 were selected and randomly divided into a control group and a study group, with 45 cases in each group. The control group received conventional rhGM-CSF gel dressing treatment, and the study group used PRP treatment on the basis of the control group. The efficacy of the two groups was analyzed and compared. Results: The total effective rate of the study group was 91.1%, which was significantly higher than that of the control group (68.8%) (P 2/w, which was faster than that of the control group (0.26 ± 0.06 cm2/w) (P P P < 0.05). Conclusion: PRP combined with rhGM-CSF gel is effective in treating venous ulcers of lower extremities and can accelerate wound healing, which is worthy of clinical promotion.展开更多
目的通过临床对比研究,探讨重组人粒细胞巨噬细胞集落刺激因子(recombinant human granulocyte-macrophage colony-stimulating factor,rhGMCSF)凝胶剂对深Ⅱ度烧伤创面溶痂及愈合的作用及其机制。方法以2008年12月-2010年12月收治的符...目的通过临床对比研究,探讨重组人粒细胞巨噬细胞集落刺激因子(recombinant human granulocyte-macrophage colony-stimulating factor,rhGMCSF)凝胶剂对深Ⅱ度烧伤创面溶痂及愈合的作用及其机制。方法以2008年12月-2010年12月收治的符合选择标准的58例深Ⅱ度烧伤患者作为试验对象。男36例,女22例;年龄12～67岁,平均32.4岁。热液烫伤38例,火焰烧伤20例。受伤至治疗时间为1～3d,平均2.1d。采用随机双盲、自身对照方法,分为给予rhGMCSF凝胶剂治疗组(试验组)及不含rhGMCSF的凝胶剂基质治疗组(对照组)。两组用药面积比较差异无统计学意义(P>0.05),具有可比性。用药后观察创面情况,于2、6、10、14、18d计算创面溶痂率,记录完全溶痂时间及创面愈合时间。结果与对照组相比,试验组用药4d后黄白色坏死组织或痂皮逐渐变软;6d后坏死组织易浮动而脱落或痂皮边缘翘起,基底红白相间,深层肉芽组织增长迅速;8d时痂皮基本溶解。用药2d后试验组创面溶痂率即高于对照组,除用药后18d,其余各时间点两组创面溶痂率比较差异均有统计学意义(P<0.05)。试验组完全溶痂时间为(7.71±2.76)d,较对照组(14.71±3.63)d明显缩短(t=13.726,P=0.000);创面愈合时间为(18.41±2.47)d,亦较对照组(23.58±3.35)d明显缩短(t=15.763,P=0.000)。结论 rhGMCSF凝胶剂与单纯凝胶剂基质相比能促进深Ⅱ度烧伤创面坏死组织脱落,加快创面愈合。展开更多
文摘目的:分析自体富血小板血浆(PRP)联合重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶治疗下肢静脉性溃疡的临床效果。方法:选取2023年9月~2024年7月西京医院烧伤与皮肤外科门诊换药中心收治的90例下肢静脉性溃疡患者,采用随机数字表法分为对照组和研究组,每组各45例。对照组采取常规的rhGM-CSF凝胶换药治疗,研究组在对照组基础上联合使用PRP治疗,分析比较两组疗效。结果:研究组总有效率91.1%,明显高于对照组68.8% (P 2/w,较对照组0.26 ± 0.06 cm2/w快(P P P Objective: To analyze the clinical effect of autologous platelet-rich plasma (PRP) combined with recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) gel in the treatment of venous lower extremity ulcers. Methods: A total of 90 patients with venous lower extremity ulcers admitted to the Outpatient Dressing Center of the Department of Burn and Dermatology Surgery of Xijing Hospital from September 2023 to July 2024 were selected and randomly divided into a control group and a study group, with 45 cases in each group. The control group received conventional rhGM-CSF gel dressing treatment, and the study group used PRP treatment on the basis of the control group. The efficacy of the two groups was analyzed and compared. Results: The total effective rate of the study group was 91.1%, which was significantly higher than that of the control group (68.8%) (P 2/w, which was faster than that of the control group (0.26 ± 0.06 cm2/w) (P P P < 0.05). Conclusion: PRP combined with rhGM-CSF gel is effective in treating venous ulcers of lower extremities and can accelerate wound healing, which is worthy of clinical promotion.
