Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in viv...Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.展开更多
Based on thermodynamics and physical chemistry theory,the theoretical energy consumption (TEC) of the typical separating processes of Al,Ca and Mg has been calculated and analyzed.This paper attempts to prove that the...Based on thermodynamics and physical chemistry theory,the theoretical energy consumption (TEC) of the typical separating processes of Al,Ca and Mg has been calculated and analyzed.This paper attempts to prove that the thermal method is more reasonable than the electrolytic methods to separate Al,Ca and Mg under the domestic circumstances of the low efficiency of coal-firing power plant at present.展开更多
基金supported by the National Natural Science Foundation of China (31600766, 21473138 and 81330031)the Fundamental Research Funds for the Central Universities (No. 2682016CX076)
文摘Biodegradable magnesium（Mg）-based vascular stents have been designed as temporary scaffolds to treat angiostenotic lesions for the maintenance of normal blood flow.Numerous studies have presented in vitro and in vivo tests for the evaluation of the safety and feasibility of Mg-based vascular stents and the related materials. Therein the cytocompatibility is a basic and important parameter in the evaluation system. In this review, we summarize the applications and limitations of in vitro evaluation methods including basic characterization methods and direct and indirect cytotoxicity tests. We discuss the influencing factors on cytotoxicity, such as surface roughness, preconditioning of sample surface, cell type for the biocompatibility evaluation in direct contact as well as conditions for the formation of extracts/degradation products for indirect assays. Besides, we highlight the recent in vivo animal tests and clinical trials about Mgbased stents along with some associated results. The aim of this review is to provide a meaningful reference in the further developments and related evaluation methods of Mg-based stents.
文摘Based on thermodynamics and physical chemistry theory,the theoretical energy consumption (TEC) of the typical separating processes of Al,Ca and Mg has been calculated and analyzed.This paper attempts to prove that the thermal method is more reasonable than the electrolytic methods to separate Al,Ca and Mg under the domestic circumstances of the low efficiency of coal-firing power plant at present.
