Background: Most data on the outcome of basilar artery occlusion are from recent case series of patients treated with intra-arterial thrombolysis. The limited knowledge on the outcome after a conventional treatment ap...Background: Most data on the outcome of basilar artery occlusion are from recent case series of patients treated with intra-arterial thrombolysis. The limited knowledge on the outcome after a conventional treatment approach comes from a few small case series of highly selected patients. Abstract:Objective: to provide more data on the outcome of conventional treatment. Methods: Data were analysed on patients from three centres with symptomatic basilar artery occlusion treated conventionally. Conventional therapy was defined as treatment with antiplatelets, anticoagulation, or both. Results: Data were available on 82 patients. The case fatality was 40%. Among survivors, 65%remained dependent (Rankin score 4-5). Patients younger than 60 years (odds ratio = 3.1 (95%confidence interval, 1.0 to 9.5)) and those with a minor stroke (OR = 3.1 (1.0 to 9.6)) were more likely to have a good outcome (Rankin score 0-3). Patients with a progressive stroke were less likely to have a good outcome (OR = 0.3 (0.08 to 1.2)) than patients with a maximum deficit at onset or fluctuating symptoms at presentation. Conclusions: Conventional treatment of symptomatic basilar artery occlusion is associated with a poor outcome in almost 80%of patients, which emphasises the importance of the search for a more effective treatment approach.展开更多
许多随机试验和meta分析对血管内治疗(endovascular treatment,EVT)前静脉溶栓(intravenous thrombolysis,IVT)的有效性进行了探讨,但这些研究主要涉及前循环闭塞。因此,荷兰马斯特里赫特大学医学中心的Knapen等利用MR CLEAN(Multicente...许多随机试验和meta分析对血管内治疗(endovascular treatment,EVT)前静脉溶栓(intravenous thrombolysis,IVT)的有效性进行了探讨,但这些研究主要涉及前循环闭塞。因此,荷兰马斯特里赫特大学医学中心的Knapen等利用MR CLEAN(Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands)的数据进行了一项研究,旨在探讨后循环闭塞患者EVT前进行IVT的临床、技术和安全性结果。展开更多
合并串联颈动脉闭塞的急性缺血性卒中患者的最佳治疗方案和转归尚不清楚。因此,奥地利维也纳医科大学的Marko等利用ESCAPE-NA1(Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke)试验...合并串联颈动脉闭塞的急性缺血性卒中患者的最佳治疗方案和转归尚不清楚。因此,奥地利维也纳医科大学的Marko等利用ESCAPE-NA1(Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke)试验数据进行了一项分析,旨在探讨串联闭塞患者的转归和治疗策略。展开更多
文摘Background: Most data on the outcome of basilar artery occlusion are from recent case series of patients treated with intra-arterial thrombolysis. The limited knowledge on the outcome after a conventional treatment approach comes from a few small case series of highly selected patients. Abstract:Objective: to provide more data on the outcome of conventional treatment. Methods: Data were analysed on patients from three centres with symptomatic basilar artery occlusion treated conventionally. Conventional therapy was defined as treatment with antiplatelets, anticoagulation, or both. Results: Data were available on 82 patients. The case fatality was 40%. Among survivors, 65%remained dependent (Rankin score 4-5). Patients younger than 60 years (odds ratio = 3.1 (95%confidence interval, 1.0 to 9.5)) and those with a minor stroke (OR = 3.1 (1.0 to 9.6)) were more likely to have a good outcome (Rankin score 0-3). Patients with a progressive stroke were less likely to have a good outcome (OR = 0.3 (0.08 to 1.2)) than patients with a maximum deficit at onset or fluctuating symptoms at presentation. Conclusions: Conventional treatment of symptomatic basilar artery occlusion is associated with a poor outcome in almost 80%of patients, which emphasises the importance of the search for a more effective treatment approach.
文摘许多随机试验和meta分析对血管内治疗(endovascular treatment,EVT)前静脉溶栓(intravenous thrombolysis,IVT)的有效性进行了探讨,但这些研究主要涉及前循环闭塞。因此,荷兰马斯特里赫特大学医学中心的Knapen等利用MR CLEAN(Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands)的数据进行了一项研究,旨在探讨后循环闭塞患者EVT前进行IVT的临床、技术和安全性结果。
文摘合并串联颈动脉闭塞的急性缺血性卒中患者的最佳治疗方案和转归尚不清楚。因此,奥地利维也纳医科大学的Marko等利用ESCAPE-NA1(Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke)试验数据进行了一项分析,旨在探讨串联闭塞患者的转归和治疗策略。
