在装配整体式剪力墙结构中,由于套筒灌浆连接的质量具有一定的随机性,势必影响结构的竖向连接性能和结构抗震性能。根据不同缺陷程度的套筒灌浆拉拔试验,建立了一套等效套筒灌浆缺陷连接承载力模型,并基于某实际工程结构,建立了装配整...在装配整体式剪力墙结构中,由于套筒灌浆连接的质量具有一定的随机性,势必影响结构的竖向连接性能和结构抗震性能。根据不同缺陷程度的套筒灌浆拉拔试验,建立了一套等效套筒灌浆缺陷连接承载力模型,并基于某实际工程结构,建立了装配整体式剪力墙结构有限元模型。通过考虑灌浆缺陷的随机性,赋予连接接头相应缺陷程度的力学连接性能,来反映套筒灌浆中可能存在的缺陷。通过非线性有限元分析并结合概率密度演化方法(probability density evolution method,PDEM)进行了结构随机非线性反应分析和可靠度评估。结果表明:在动力作用下,结构非线性与随机性具有明显的耦合效应;缺陷的随机性会随着时间的推移,逐渐放大对结构响应的影响;在不同的安全域内,结构的整体可靠度将存在较大的差异。展开更多
The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating ...The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating the effect of a certain intervention. However, in clinical trials, even after randomization, there are situations where the patients differ substantially with respect to the baseline value of the outcome variable. Many a times the response to interventions depends on the baseline values of the outcome variable. When there are baseline-dependent treatment effects, differences among treatments vary as a function of baseline level. Although variation in outcome associated with baseline value is accounted for in ANCOVA, analysis of individual differences in treatment effect is precluded by the homogeneity of regression assumption. This assumption requires that expected differences in outcome among treatments be constant across all baseline levels. To overcome this difficulty, Weigel and Narvaez [7] proposed a regression model for two treatment groups to analyze individual response to treatments in randomized controlled clinical trials. The authors reviewed the model suggested by Weigel and Narvaez and extended further for three or more treatment groups. The utility of the model was demonstrated with real life data from a randomized controlled clinical trial of bronchial asthma.展开更多
文摘在装配整体式剪力墙结构中,由于套筒灌浆连接的质量具有一定的随机性,势必影响结构的竖向连接性能和结构抗震性能。根据不同缺陷程度的套筒灌浆拉拔试验,建立了一套等效套筒灌浆缺陷连接承载力模型,并基于某实际工程结构,建立了装配整体式剪力墙结构有限元模型。通过考虑灌浆缺陷的随机性,赋予连接接头相应缺陷程度的力学连接性能,来反映套筒灌浆中可能存在的缺陷。通过非线性有限元分析并结合概率密度演化方法(probability density evolution method,PDEM)进行了结构随机非线性反应分析和可靠度评估。结果表明:在动力作用下,结构非线性与随机性具有明显的耦合效应;缺陷的随机性会随着时间的推移,逐渐放大对结构响应的影响;在不同的安全域内,结构的整体可靠度将存在较大的差异。
文摘The primary aim of clinical trials is to investigate whether a treatment is effective for a particular disease or condition. Randomized controlled clinical trials are considered to be the gold standard for evaluating the effect of a certain intervention. However, in clinical trials, even after randomization, there are situations where the patients differ substantially with respect to the baseline value of the outcome variable. Many a times the response to interventions depends on the baseline values of the outcome variable. When there are baseline-dependent treatment effects, differences among treatments vary as a function of baseline level. Although variation in outcome associated with baseline value is accounted for in ANCOVA, analysis of individual differences in treatment effect is precluded by the homogeneity of regression assumption. This assumption requires that expected differences in outcome among treatments be constant across all baseline levels. To overcome this difficulty, Weigel and Narvaez [7] proposed a regression model for two treatment groups to analyze individual response to treatments in randomized controlled clinical trials. The authors reviewed the model suggested by Weigel and Narvaez and extended further for three or more treatment groups. The utility of the model was demonstrated with real life data from a randomized controlled clinical trial of bronchial asthma.
