Photothermal agents with improved bioavailabilities can generate heat from near-infrared light, which has been efficiently used for in vivo photothermal therapy （PTT） for cancer, with minimum tissue invasion. Strate...Photothermal agents with improved bioavailabilities can generate heat from near-infrared light, which has been efficiently used for in vivo photothermal therapy （PTT） for cancer, with minimum tissue invasion. Strategies for developing organic near-infrared-absorbing molecules for phototfiermal cancer therapy have drawn intensive attention among academic investigators. However, conventional organic nearinfrared-absorbing molecules may not only have complex synthesis procedures, but also easily suffer from photobleaching under light irradiation. These drawbacks might lead to an increase in the synthesis cost, and elicit a risk of side effects in PTF. Thus, it is essential to devise an organic photothermal agent with stable phototbermal capacity, which involves a facile synthesis process. In this study, incorporating a secondary amine group （donor） in the bay regions of perylenediimides （PDls） could lead to a 150-nm bathochromic shift of the absorption maximum. Next, a modification of poly（ethylene glycol） （PEG） at the periphery of the chromophore renders the targeted macromolecule PDI-PEG highly water-soluble, and capable of intense absorption in the near-infrared region. The self-assembled PDl-based nanoparti- des （PDI-NPs） have a size of 55 nm in aqueous solutions. PDI-NPs with excellent photostability possess a high photothermal conversion efficiency of up to 43% ± 2%. Finally, PDI-NPs allow for efficient in vitro and in vivo photothermal cancer therapy. Meanwhile, PDI-NPs exhibit quite low cytotoxicity and no biotoxicity on major organs in vivo. Thus, these easily-manufactured PDI-NPs can serve as extremely stable photothermal agents for efficient photothermal cancer therapy.展开更多
基金supported by the National Natural Science Foundation of China (201774007, 21574009, 51521062 and 51573012)the Higher Education and High-quality and World-class Universities (PY201605)
文摘Photothermal agents with improved bioavailabilities can generate heat from near-infrared light, which has been efficiently used for in vivo photothermal therapy （PTT） for cancer, with minimum tissue invasion. Strategies for developing organic near-infrared-absorbing molecules for phototfiermal cancer therapy have drawn intensive attention among academic investigators. However, conventional organic nearinfrared-absorbing molecules may not only have complex synthesis procedures, but also easily suffer from photobleaching under light irradiation. These drawbacks might lead to an increase in the synthesis cost, and elicit a risk of side effects in PTF. Thus, it is essential to devise an organic photothermal agent with stable phototbermal capacity, which involves a facile synthesis process. In this study, incorporating a secondary amine group （donor） in the bay regions of perylenediimides （PDls） could lead to a 150-nm bathochromic shift of the absorption maximum. Next, a modification of poly（ethylene glycol） （PEG） at the periphery of the chromophore renders the targeted macromolecule PDI-PEG highly water-soluble, and capable of intense absorption in the near-infrared region. The self-assembled PDl-based nanoparti- des （PDI-NPs） have a size of 55 nm in aqueous solutions. PDI-NPs with excellent photostability possess a high photothermal conversion efficiency of up to 43% ± 2%. Finally, PDI-NPs allow for efficient in vitro and in vivo photothermal cancer therapy. Meanwhile, PDI-NPs exhibit quite low cytotoxicity and no biotoxicity on major organs in vivo. Thus, these easily-manufactured PDI-NPs can serve as extremely stable photothermal agents for efficient photothermal cancer therapy.
