Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cance...Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cancer death in the world. Although the incidence and mortality of gastric carcinoma are decreasing in many countries,gastric cancer still represents the second most frequent malignancies in the world and the fourth in Europe. The 5-year survival rate of gastric carcinoma is low. The etiology and pathogenesis are not yet fully known. The study of gastric cancer is important in clinical medicine as well as in public health. Over the past 15 years,integrated research in molecular pathology has clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of the development and progression of gastric cancer. Gastric cancer, as all cancers, is the end result of the interplay of many risk factors as well as protective factors. Although epidemiological evidence indicates that environmental factors play a major role in gastric carcinogenesis, the role of immunological, genetic, and immunogenetic factors are thought to contribute to the pathogenesis of gastric carcinoma. Among the environmental factors,diet and Helicobacter pylori are more amenable to intervention aimed at the prevention of gastric cancer.The aim of the present paper is to review and include the most recent published evidence to demonstrate that only a multidisciplinary approach will lead to the advancement of the pathogenesis and prevention of gastric cancer. On the immunogenetic research it is clear that evidence is accumulating to suggest that a genetic profile favoring the proinflammatory response increases the risk of gastric carcinoma.展开更多
In recent years,the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein,a general over...In recent years,the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein,a general overview of different tools currently available,including T cell and B cell epitopes prediction tools,is presented. And the principles of different prediction algorithms are reviewed briefly. Finally,several examples are present to illustrate the application of the prediction tools.展开更多
Objective: The aim of our study was to investigate the expressions of Survivin and Caspase-3 in the hepatocellular carcinoma (HCC) and the paracancerous liver tissues, and define the relationship between the expressio...Objective: The aim of our study was to investigate the expressions of Survivin and Caspase-3 in the hepatocellular carcinoma (HCC) and the paracancerous liver tissues, and define the relationship between the expression and the patients survival rate after surgery. Methods: The expressions of PCNA, Survivin and Caspase-3 were detected by immunohistochemistry. PCNA positive level was used to account proliferating cell nuclear antigen proliferating index (PCNA-PI). The apoptosis index of HCC tissues was detected by TUNEL. Results: The expression of Survivin in HCC tissue was higher than that in paracancerous tissue (P < 0.05), while it was related with portal vein thrombosis, tumor size and histological differentia- tion (P < 0.05). In HCC tissues, the PCNA-PI of the Survivin positive group was higher than the negative (P < 0.05) group, and the AI of the Survivin positive group was lower than the negative group (P < 0.05). The expression of Caspasse-3 in HCC tissue was lower than that in paracancerous tissue (P < 0.05), while it was related with HBsAg and histological differentiation (P < 0.05). In HCC tissues, the average PCNA-PI of the Caspase-3 positive group was lower than that of the negative group (P < 0.05), and the average AI of the Caspase-3 positive group was higher than that of the negative group (P < 0.05). There was negative correlation between the expressions of Survivin and Caspase-3 in HCC (r = -0.242, P < 0.05). The survival rate of the Survivin positive group was lower than that of the negative group (P < 0.05), while that of the Caspase-3 positive patients was higher than that of the negative group (P < 0.05). Conclusion: The expressions of Survivin and Caspase-3 in HCC can reflex the biological behavior of HCC and patients prognosis, they may be new targets of tumor diagnosis and treatment.展开更多
Since rough surface scattering has a great impact on the accuracy of the propagation prediction algorithm,an integrated algorithm for indoor propagation prediction including rough surface scattering is proposed here.T...Since rough surface scattering has a great impact on the accuracy of the propagation prediction algorithm,an integrated algorithm for indoor propagation prediction including rough surface scattering is proposed here.This algorithm is composed of a three dimensional(3D) ray tracing algorithm based on binary space partitioning(BSP) and a diffuse scattering algorithm based on Oren-Nayar's theory.Lack of accuracy and prohibitive time consumption are the main drawbacks of the existing ray tracing based propagation prediction models.To defy these shortcomings,the balanced BSP tree is used in the proposed algorithm to accelerate the ray tracing,while the nearest object priority technique(NOP) and in contact surface(ICS) is used to eliminate the repeated rayobject intersection tests.Therefore,the final criteria of this study are the time consumption as well as accuracy by predicting the field strength and the number of received signals.Using the proposed approaches,our algorithm becomes faster and more accurate than the existing algorithms.A detailed comparative study with existing algorithms shows that the proposed algorithm has at most 37.83%higher accuracy and 34.44%lower time consumption.Moreover,effects of NOP and ICS techniques and scattering factor on time and ray prediction accuracy are also presented.展开更多
Using the seismic method to detect active faults directly below cities is an irreplaceable prospecting technique. The seismic method can precisely determine the fault position. Seismic method itself can hardly determi...Using the seismic method to detect active faults directly below cities is an irreplaceable prospecting technique. The seismic method can precisely determine the fault position. Seismic method itself can hardly determine the geological age of fault. However, by considering in connection with the borehole data and the standard geological cross-section of the surveyed area, the geological age of reflected wave group can be qualitatively (or semi-quantitatively) determined from the seismic depth profile. To determine the upper terminal point of active faults directly below city, it is necessary to use the high-resolution seismic reflection technique. To effectively determine the geometric feature of deep faults, especially to determine the relation between deep and shallow fracture structures, the seismic reflection method is better than the seismic refraction method.展开更多
Truth-conditional approaches to tense and other temporal expressions have relied on both linear-time and branching-time frameworks as needed. However, in the truth-conditional enterprise generally, it seems advisable ...Truth-conditional approaches to tense and other temporal expressions have relied on both linear-time and branching-time frameworks as needed. However, in the truth-conditional enterprise generally, it seems advisable to settle on a single depiction of time. Linear time is the simpler framework, and branching time faces difficulties for which we seem to have no immediate solutions. This paper defends the applicability of linear time. The apparent branching of time results from the use of speech acts other than factual assertion. Truth in correspondence with specific conditions is relevant when making factual assertions. However, we are in no epistemic position to advance factual assertions about the future, but only suppositions and predictions. For these, the truth-conditional content is employed differently. For suppositions and predictions, we only ＂pretend＂ to reference things, to assert facts, and to accept them as ＂true.＂ There is a wide array of alternatives about what we can suppose or predict, giving the impression of branching options. Suppositions and predictions under active consideration are often marked with present tense, whereas those that are inactive （not presently under active consideration but nonetheless relevant） are often marked with past tense.展开更多
To solve the problems generally encountered during the plasma electrolytic oxidation(PEO) of Al alloys with high Si content, a pretreatment of chemical etching was applied before the process. The influence of such pre...To solve the problems generally encountered during the plasma electrolytic oxidation(PEO) of Al alloys with high Si content, a pretreatment of chemical etching was applied before the process. The influence of such pretreatment was studied by SEM, EDS and XRD. The pretreatment presents a significant effect on positive voltage at the beginning stage of PEO, leading to higher voltage over the whole process. The difference between the positive voltages of non-etched and etched specimens decreases gradually with the increase of processing time. The pretreatment exhibits much less influence on the negative voltage. For the sample with surface pretreatment, the average growth rate of PEO coating is increased from 0.50 to 0.84 μm·min-1and the energy consumption is decreased from 6.30 to 4.36 k W·h·μm-1·m-2. At the same time, both mullite and amorphous Si O2 contents are decreased in the coating.展开更多
This paper deals with the estimation of crest settlement in a concrete face rockfill dam （CFRD）, utilizing intelligent methods. Following completion of dam construction, considerable movements of the crest and the b...This paper deals with the estimation of crest settlement in a concrete face rockfill dam （CFRD）, utilizing intelligent methods. Following completion of dam construction, considerable movements of the crest and the body of the dam can develop during the first impoundment of the reservoir. Although there is vast experience worldwide in CFRD design and construction, few accurate experimental relationships are available to predict the settlement in CFRD. The goal is to advance the development of intelligent methods to estimate the subsidence of dams at the design stage. Due to dam zonifieation and uncertainties in material properties, these methods appear to be the appropriate choice. In this study, the crest settlement behavior of CFRDs is analyzed based on compiled data of 24 CFRDs constructed during recent years around the world, along with the utilization of gene ex- pression programming （GEP） and adaptive neuro-fuzzy inference system （ANFIS） methods. In addition, dam height （H）, shape factor （St）, and time （t, time after first operation） are also assessed, being considered major factors in predicting the settlement behavior. From the relationships proposed, the values ofR2 for both equations of GEP （with and without constant） were 0.9603 and 0.9734, and for the three approaches of ANFIS （grid partitioning （GP）, subtractive clustering method （SCM）, and fuzzy c-means clustering （FCM）） were 0.9693, 0.8657, and 0.8848, respectively. The obtained results indicate that the overall behavior evaluated by this approach is consistent with the measured data of other CFRDs.展开更多
基金Supported by the Foundation of Immunogenetics and Cluster I of VU University Medical Center, Amsterdam
文摘Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cancer death in the world. Although the incidence and mortality of gastric carcinoma are decreasing in many countries,gastric cancer still represents the second most frequent malignancies in the world and the fourth in Europe. The 5-year survival rate of gastric carcinoma is low. The etiology and pathogenesis are not yet fully known. The study of gastric cancer is important in clinical medicine as well as in public health. Over the past 15 years,integrated research in molecular pathology has clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of the development and progression of gastric cancer. Gastric cancer, as all cancers, is the end result of the interplay of many risk factors as well as protective factors. Although epidemiological evidence indicates that environmental factors play a major role in gastric carcinogenesis, the role of immunological, genetic, and immunogenetic factors are thought to contribute to the pathogenesis of gastric carcinoma. Among the environmental factors,diet and Helicobacter pylori are more amenable to intervention aimed at the prevention of gastric cancer.The aim of the present paper is to review and include the most recent published evidence to demonstrate that only a multidisciplinary approach will lead to the advancement of the pathogenesis and prevention of gastric cancer. On the immunogenetic research it is clear that evidence is accumulating to suggest that a genetic profile favoring the proinflammatory response increases the risk of gastric carcinoma.
基金The National Natural Science Foundations of China (30870131)the National Key Projects in the Infectious Fields (2008ZX10002-011, 2008ZX10004-004)
文摘In recent years,the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein,a general overview of different tools currently available,including T cell and B cell epitopes prediction tools,is presented. And the principles of different prediction algorithms are reviewed briefly. Finally,several examples are present to illustrate the application of the prediction tools.
文摘Objective: The aim of our study was to investigate the expressions of Survivin and Caspase-3 in the hepatocellular carcinoma (HCC) and the paracancerous liver tissues, and define the relationship between the expression and the patients survival rate after surgery. Methods: The expressions of PCNA, Survivin and Caspase-3 were detected by immunohistochemistry. PCNA positive level was used to account proliferating cell nuclear antigen proliferating index (PCNA-PI). The apoptosis index of HCC tissues was detected by TUNEL. Results: The expression of Survivin in HCC tissue was higher than that in paracancerous tissue (P < 0.05), while it was related with portal vein thrombosis, tumor size and histological differentia- tion (P < 0.05). In HCC tissues, the PCNA-PI of the Survivin positive group was higher than the negative (P < 0.05) group, and the AI of the Survivin positive group was lower than the negative group (P < 0.05). The expression of Caspasse-3 in HCC tissue was lower than that in paracancerous tissue (P < 0.05), while it was related with HBsAg and histological differentiation (P < 0.05). In HCC tissues, the average PCNA-PI of the Caspase-3 positive group was lower than that of the negative group (P < 0.05), and the average AI of the Caspase-3 positive group was higher than that of the negative group (P < 0.05). There was negative correlation between the expressions of Survivin and Caspase-3 in HCC (r = -0.242, P < 0.05). The survival rate of the Survivin positive group was lower than that of the negative group (P < 0.05), while that of the Caspase-3 positive patients was higher than that of the negative group (P < 0.05). Conclusion: The expressions of Survivin and Caspase-3 in HCC can reflex the biological behavior of HCC and patients prognosis, they may be new targets of tumor diagnosis and treatment.
基金financial support under the University of Malaya Research Grant(UMRG) scheme(RG098/12ICT)
文摘Since rough surface scattering has a great impact on the accuracy of the propagation prediction algorithm,an integrated algorithm for indoor propagation prediction including rough surface scattering is proposed here.This algorithm is composed of a three dimensional(3D) ray tracing algorithm based on binary space partitioning(BSP) and a diffuse scattering algorithm based on Oren-Nayar's theory.Lack of accuracy and prohibitive time consumption are the main drawbacks of the existing ray tracing based propagation prediction models.To defy these shortcomings,the balanced BSP tree is used in the proposed algorithm to accelerate the ray tracing,while the nearest object priority technique(NOP) and in contact surface(ICS) is used to eliminate the repeated rayobject intersection tests.Therefore,the final criteria of this study are the time consumption as well as accuracy by predicting the field strength and the number of received signals.Using the proposed approaches,our algorithm becomes faster and more accurate than the existing algorithms.A detailed comparative study with existing algorithms shows that the proposed algorithm has at most 37.83%higher accuracy and 34.44%lower time consumption.Moreover,effects of NOP and ICS techniques and scattering factor on time and ray prediction accuracy are also presented.
文摘Using the seismic method to detect active faults directly below cities is an irreplaceable prospecting technique. The seismic method can precisely determine the fault position. Seismic method itself can hardly determine the geological age of fault. However, by considering in connection with the borehole data and the standard geological cross-section of the surveyed area, the geological age of reflected wave group can be qualitatively (or semi-quantitatively) determined from the seismic depth profile. To determine the upper terminal point of active faults directly below city, it is necessary to use the high-resolution seismic reflection technique. To effectively determine the geometric feature of deep faults, especially to determine the relation between deep and shallow fracture structures, the seismic reflection method is better than the seismic refraction method.
文摘Truth-conditional approaches to tense and other temporal expressions have relied on both linear-time and branching-time frameworks as needed. However, in the truth-conditional enterprise generally, it seems advisable to settle on a single depiction of time. Linear time is the simpler framework, and branching time faces difficulties for which we seem to have no immediate solutions. This paper defends the applicability of linear time. The apparent branching of time results from the use of speech acts other than factual assertion. Truth in correspondence with specific conditions is relevant when making factual assertions. However, we are in no epistemic position to advance factual assertions about the future, but only suppositions and predictions. For these, the truth-conditional content is employed differently. For suppositions and predictions, we only ＂pretend＂ to reference things, to assert facts, and to accept them as ＂true.＂ There is a wide array of alternatives about what we can suppose or predict, giving the impression of branching options. Suppositions and predictions under active consideration are often marked with present tense, whereas those that are inactive （not presently under active consideration but nonetheless relevant） are often marked with past tense.
基金Supported by the Natural Science Foundation of Guangdong Province,China(S2013010015211)
文摘To solve the problems generally encountered during the plasma electrolytic oxidation(PEO) of Al alloys with high Si content, a pretreatment of chemical etching was applied before the process. The influence of such pretreatment was studied by SEM, EDS and XRD. The pretreatment presents a significant effect on positive voltage at the beginning stage of PEO, leading to higher voltage over the whole process. The difference between the positive voltages of non-etched and etched specimens decreases gradually with the increase of processing time. The pretreatment exhibits much less influence on the negative voltage. For the sample with surface pretreatment, the average growth rate of PEO coating is increased from 0.50 to 0.84 μm·min-1and the energy consumption is decreased from 6.30 to 4.36 k W·h·μm-1·m-2. At the same time, both mullite and amorphous Si O2 contents are decreased in the coating.
文摘This paper deals with the estimation of crest settlement in a concrete face rockfill dam （CFRD）, utilizing intelligent methods. Following completion of dam construction, considerable movements of the crest and the body of the dam can develop during the first impoundment of the reservoir. Although there is vast experience worldwide in CFRD design and construction, few accurate experimental relationships are available to predict the settlement in CFRD. The goal is to advance the development of intelligent methods to estimate the subsidence of dams at the design stage. Due to dam zonifieation and uncertainties in material properties, these methods appear to be the appropriate choice. In this study, the crest settlement behavior of CFRDs is analyzed based on compiled data of 24 CFRDs constructed during recent years around the world, along with the utilization of gene ex- pression programming （GEP） and adaptive neuro-fuzzy inference system （ANFIS） methods. In addition, dam height （H）, shape factor （St）, and time （t, time after first operation） are also assessed, being considered major factors in predicting the settlement behavior. From the relationships proposed, the values ofR2 for both equations of GEP （with and without constant） were 0.9603 and 0.9734, and for the three approaches of ANFIS （grid partitioning （GP）, subtractive clustering method （SCM）, and fuzzy c-means clustering （FCM）） were 0.9693, 0.8657, and 0.8848, respectively. The obtained results indicate that the overall behavior evaluated by this approach is consistent with the measured data of other CFRDs.
