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基于Wolff定律的各向异性骨再造模型 被引量:8
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作者 马宗民 李淑娴 朱兴华 《中国生物医学工程学报》 CAS CSCD 北大核心 2007年第6期908-911,共4页
建立符合各向异性骨再造生理过程的骨再造数值理论模型。基于Wolff定律及骨各向异性的力学性质,在仔细研究了当前各向同性骨结构再造数值模拟预测技术的基础上,将材料方向和主应力方向趋于一致做为骨再造平衡条件,提出一新型各向异性骨... 建立符合各向异性骨再造生理过程的骨再造数值理论模型。基于Wolff定律及骨各向异性的力学性质,在仔细研究了当前各向同性骨结构再造数值模拟预测技术的基础上,将材料方向和主应力方向趋于一致做为骨再造平衡条件,提出一新型各向异性骨再造数值模型。以二维悬臂梁结构为例进行了模拟,得到了二维悬臂梁结构的密度分布图。新型各向异性骨再造数值模型,量化了骨再造过程和骨力学性质的各向异性,实现了骨再造过程数值模拟的各向异性。应用该模型可进行更为准确的骨结构再造数值预测。 展开更多
关键词 Wolff定律 各向异性 骨再造模型 骨力学性质
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各向异性骨再造过程的实现
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作者 马宗民 李淑娴 朱兴华 《航天医学与医学工程》 CAS CSCD 北大核心 2007年第1期28-31,共4页
目的建立符合各向异性骨再造过程的骨再造理论模型,实现各向异性骨再造过程。方法基于Wolff定律及骨各向异性的力学性质,在仔细研究当前各向同性骨结构再造预测技术的基础上,将材料方向和主应力方向趋于一致作为骨再造平衡条件,提出新... 目的建立符合各向异性骨再造过程的骨再造理论模型,实现各向异性骨再造过程。方法基于Wolff定律及骨各向异性的力学性质,在仔细研究当前各向同性骨结构再造预测技术的基础上,将材料方向和主应力方向趋于一致作为骨再造平衡条件,提出新型各向异性骨再造模型,并以二维简支梁结构为例进行模拟。结果得到了二维简支梁结构的密度分布结果与主应力方向迹线图,并与各向同性模拟结果进行了对照,显示本模型模拟结果较为合理。结论新型各向异性骨再造模型,量化了骨再造过程和骨力学性质的各向异性,实现了骨再造过程的各向异性,应用该模型可进行更为准确的骨结构再造预测。 展开更多
关键词 Wolff定律 各向异性 骨再造 骨力学性质
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Biomechanical researches on tissue engineering bone constructed by deproteinated bone 被引量:3
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作者 简月奎 田晓滨 +5 位作者 李起鸿 李波 彭智 赵伟峰 王远政 杨震 《Chinese Journal of Traumatology》 CAS 2010年第1期32-36,共5页
Objective: To study biomechanical changes of newly formed bones 24 weeks after repairing large defects of long bones of goats using heterogeneous deproteinated bone (DPB) prepared by modified methods as an engineer... Objective: To study biomechanical changes of newly formed bones 24 weeks after repairing large defects of long bones of goats using heterogeneous deproteinated bone (DPB) prepared by modified methods as an engineering scaffold. Methods: According to a fully randomized design, 18 goats were evenly divided into three groups: normal bone control group (Group A), autologous bone group (Group B) and experimental group (Group C). Each goat in Groups B and C were subjected to the periosteum and bone defect at middle-lower part of the right tibia (20% of the whole tibia in length), followed by autologous bone or DPB plus autolognus MSCs + rhBMP2 implantation, respectively and semi- ring slot fixation; while goats in Group A did not perform osteotomy. At 24 weeks after surgery, biomechanical tests were carried out on the tibias. Results: At 24 weeks after surgery, the results of anticompression test on tibias in three groups were recorded by a functional recorder presented as linear pressure-deformation curve. The shapes of the curves and their change tendency were similar among three groups. The ultimate pressure values were 10.74 MPa±1.23 MPa, 10. 11 MPa±1.35 MPa and 10.22 MPa±1.32 MPa and fracture compression rates were 26.82%±0.87%, 27.17%±0.75% and 28.22%±1.12% in Groups A, B and C, respectively. Comparisons of anti-compression ultimate pressures and fracture compression rates among three groups demonstrated no significant difference (PAB=0.415, PBC=0.494). Three-point antibend test on tibias was recorded as load-deformation curves, and the shapes of the curves and their change tendency were similar among three groups. The ultimate pressure values of the anti-bend test were 481.52 N±12.45 N, 478.34 N±14.68 N and 475.62 N±13.41 N and the fracture bend rates were 2.62 mm±0.12 mm, 2.61 mm±0.15 mm and 2.81 mm±0.13 mm in Groups A, B and C, respectively. There was no significant difference between groups (PAB=0.7, PBc=0.448). The ultimate anti-torsion torque values were 6.55 N.mi-0.25 N.m, 6.34 N'm^0.18 N'm and 6.42 N'm^0.21 N'm and fracture torsion rates were 29.51°±1.64°, 28.88±1.46° and 28.81°±1.33° in Groups A, B and C, respectively. There was no significant difference between groups (PAB=0.123, PBc=0.346). Conclusions: The biomechanical characteristics of newly formed bones from heterogeneous DPB for repairing large segmental long bone defect are comparable to those of normal bones and autologous bones. DPB has the potential for clinical usage as bone graft material. 展开更多
关键词 BIOMECHANICS Tissue engineering Deproteinated bone
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Implant-induced microdamage in osteoporotic bone
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作者 YU Zhi-feng TANG Ting-ting QIU Shi-jing 《Chinese Journal of Traumatology》 CAS 2012年第2期113-117,共5页
With the increase of elderly population, more and more implant operations need to be performed in osteoporotic bone, while different forms of microdamage will be produced in peri-implant bone intraoperatively, includi... With the increase of elderly population, more and more implant operations need to be performed in osteoporotic bone, while different forms of microdamage will be produced in peri-implant bone intraoperatively, including high- and low-density diffuse damages, as well as linear cracks. The length and location of the microcracks are the main factors in affecting the biomechanical performance of bone. Suppression of bone remodeling by bisphosphonates may lead to microdamage accumulation, which is often accompanied with the decrease of bonestrength and the increase of bone fragility. Microdamage can be repaired by bone remodeling or mineralization to maintain the strength and structural integrity. Both remodeling and mineralization can affect the bone quality and long-term implant stability, In this paper, we make a brief summary of some important issues and research progresses in this field. 展开更多
关键词 Osteoporosis postmenopausal Boneremodeling Aged
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