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脊柱外固定装置牵张下经皮椎体成形治疗后壁破损椎体骨质疏松压缩骨折 被引量:3
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作者 孙玲娟 宋西正 +4 位作者 李达明 韩枕学 康禹 向含睿 盛凯 《中国组织工程研究》 CAS 北大核心 2023年第31期4954-4958,共5页
背景:对于后壁破损椎体骨质疏松压缩骨折伴椎管占位,国内外多采用开放手术或保守治疗。老龄骨质疏松患者用脊柱外固定装置轴向牵张前后纵韧带,使椎管占位后移骨块复位,同时扩大椎管,然后行经皮椎体成形术固化椎体,在临床中取得良好的治... 背景:对于后壁破损椎体骨质疏松压缩骨折伴椎管占位,国内外多采用开放手术或保守治疗。老龄骨质疏松患者用脊柱外固定装置轴向牵张前后纵韧带,使椎管占位后移骨块复位,同时扩大椎管,然后行经皮椎体成形术固化椎体,在临床中取得良好的治疗效果。目的:观察后壁破损椎体骨质疏松压缩骨折伴椎管占位患者前后纵韧带在脊柱外固定装置牵张下行经皮椎体成形的临床疗效。方法:选取老年后壁破损椎体骨质疏松压缩骨折伴椎管占位患者52例,年龄61-86岁,平均(78.62±5.20)岁;采用脊柱外固定联合经皮椎体成形术治疗,治疗前、治疗后1 d、治疗后3个月及末次随访(术后12个月)时,用X射线片及CT观察椎体前缘高度丢失率、后凸成角、椎管狭窄率及骨折椎体内骨水泥分布范围,同时进行目测类比评分、Oswestry功能障碍指数评估。结果与结论:52例患者随访3-12个月。X射线片示治疗前、治疗后1d、治疗后3个月、末次随访时的椎体前缘高度丢失率分别为(34.5±2.2)%,(3.5±1.3)%,(4.0±0.6)%,(4.4±1.1)%,后凸成角分别为(12.1±1.7)°,(4.0±0.8)°,(3.5±0.5)°,(4.4±0.2)°,CT示椎管狭窄率分别为(40.9±7.2)%,(10.7±2.5)%,(9.7±1.1)%,(9.8±0.7)%;骨折椎体骨水泥填充分布范围均≥75%;治疗前与治疗后1 d目测类比评分、Oswestry功能障碍指数比较差异有显著性意义(P<0.05),治疗后3个月与末次随访时目测类比评分、Oswestry功能障碍指数比较差异无显著性意义(P>0.05)。结果表明,椎体前后纵韧带牵张下经皮椎体成形治疗不仅显著改善后壁破损椎体骨质疏松压缩骨折伴椎管占位复位的临床效果,还能提高椎体固化率,减轻疼痛,是一种安全有效的微创组合新技术。 展开更多
关键词 后壁破损椎体骨质疏压缩骨折 椎管占位 前后纵韧带 牵张 经皮椎体成形
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益肾中药复方防治大鼠继发性骨质疏松症的实验研究 被引量:3
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作者 王育才 丁勇 +3 位作者 范清宇 张殿忠 单乐群 尹艳 《第四军医大学学报》 北大核心 2009年第11期1001-1003,共3页
目的:益肾中药复方用于实验性继发性骨质疏松症模型大鼠,观察其疗效,并对中药复方的机制做初步的探讨.方法:使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型,同时给予益肾中药复方治疗3mo后,观察模型动物股骨骨密度(BMD)、血钙、... 目的:益肾中药复方用于实验性继发性骨质疏松症模型大鼠,观察其疗效,并对中药复方的机制做初步的探讨.方法:使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型,同时给予益肾中药复方治疗3mo后,观察模型动物股骨骨密度(BMD)、血钙、血磷、血碱性磷酸酶(AKP)理化指标.结果:益肾中药复方治疗组大鼠股骨BMD高于模型组(P<0.05),血钙、血磷、血AKP等均高于模型组(P<0.05).结论:益肾中药复方能在一定程度上缓解由糖皮质激素诱发的骨质疏松症. 展开更多
关键词 骨质疏桫病因学 中药复方 大鼠
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中西医结合治疗绝经后骨质疏松的疗效观察 被引量:5
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作者 林红晓 王东岩 《吉林医学》 CAS 2016年第7期1614-1615,共2页
目的:探讨针灸结合阿仑膦酸钠治疗绝经后骨质疏松症的疗效。方法:40例绝经后骨质疏松症患者随机分为治疗组和对照组各20例,均给予钙剂(钙尔奇600 mg/d)、骨化三醇(罗盖全)0.25 ug/d及阿仑膦酸钠(福善美)70 mg/周口服,治疗组选用百会、... 目的:探讨针灸结合阿仑膦酸钠治疗绝经后骨质疏松症的疗效。方法:40例绝经后骨质疏松症患者随机分为治疗组和对照组各20例,均给予钙剂(钙尔奇600 mg/d)、骨化三醇(罗盖全)0.25 ug/d及阿仑膦酸钠(福善美)70 mg/周口服,治疗组选用百会、大椎、脾俞、肾俞、命门、神阙、足三里、三阴交等穴,采用针刺和艾灸相结合的方法。两组均连续治疗6个月后,观察和比较患者临床症状积分和骨代谢的变化。结果:治疗6个月后两组血钙、血磷与治疗前比较均差异无统计学意义;两组Ⅰ型胶原羧基末端肽(β-Crosslaps)均较治疗前降低,腰椎和股骨颈骨密度及血清骨钙素(OPG)均较治疗前上升,治疗组改善更明显,与对照组比较差异有统计学意义(P<0.05)。两组患者症状积分均得到改善,治疗组较对照组下降更为明显(P<0.01)。结论:针灸结合阿仑膦酸钠能有效增加绝经后骨质疏松患者腰椎、股骨颈骨密度,改善患者症状积分,有较好的治疗效果。 展开更多
关键词 针灸 阿仑膦酸钠 绝经后骨质疏+>
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性激素与骨质疏松症的关系
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作者 张娟 方文 《解放军医药杂志》 CAS 1998年第2期127-129,共3页
凡有骨量减少,骨质显微结构发生变化,发生骨折的危险度增加的疾病均称为骨质疏松症。骨质疏松症主要分为两大类,即原发性骨质疏症和继发性骨质疏发症。后者可由于多种原因所致。前者主要是由于年龄增加,体内激素水平改变及骨质本身生理... 凡有骨量减少,骨质显微结构发生变化,发生骨折的危险度增加的疾病均称为骨质疏松症。骨质疏松症主要分为两大类,即原发性骨质疏症和继发性骨质疏发症。后者可由于多种原因所致。前者主要是由于年龄增加,体内激素水平改变及骨质本身生理性退行变引起。 展开更多
关键词 骨质疏松症 雌激素受体 成骨细胞 性激素 破骨细胞 雄激素受体 孕激素 糖皮质激素 骨量减少 原发性骨质疏
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骨质疏松的药物治疗 被引量:6
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作者 林秋喜 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2006年第B03期163-164,共2页
【目的】研究抗骨质疏松药物对中老年人骨质疏松的治疗效果。【方法】药物降钙素,间断用药,每天50IU肌肉注射,14天后改为每周注射2~3次,每次50IU,疗程3~6个月。活性维生素D,即罗盖全每日0.25μg。雌激素,即结合性马雌激素0.625mg/d。... 【目的】研究抗骨质疏松药物对中老年人骨质疏松的治疗效果。【方法】药物降钙素,间断用药,每天50IU肌肉注射,14天后改为每周注射2~3次,每次50IU,疗程3~6个月。活性维生素D,即罗盖全每日0.25μg。雌激素,即结合性马雌激素0.625mg/d。双膦酸盐,每天10 mg口服。【结果】总人数102例,通过上述药物治疗,疼痛症状消失80例,明显缓解91例,有效率达90%以上。【结论】抗骨质疏松药对骨质疏松有明显治疗效果。 展开更多
关键词 骨质 活性钙 降钙素 雌激素 双膦酸盐
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骨质疏松症对颌骨影响的研究进展
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作者 陈守平 周正炎 《口腔颌面外科杂志》 CAS 2000年第2期154-156,共3页
关键词 骨质疏 颌骨 颌骨骨丧失 防治
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X线数字摄影在老年性骨质疏松症中的诊断应用 被引量:4
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作者 闫文都 《中国实用医药》 2011年第25期51-52,共2页
目的探讨X线数字摄影(DR)在老年性骨质疏松症诊断中的优缺点,了解老年性骨质疏松症的主要X线表现。方法选择近二年来本院老年性患者DR片,并进行分析。结果老年性骨质疏松症主要表现为:①骨密度减低,骨小梁模糊,变细,减少,皮质变薄。②骨... 目的探讨X线数字摄影(DR)在老年性骨质疏松症诊断中的优缺点,了解老年性骨质疏松症的主要X线表现。方法选择近二年来本院老年性患者DR片,并进行分析。结果老年性骨质疏松症主要表现为:①骨密度减低,骨小梁模糊,变细,减少,皮质变薄。②骨折,椎体可呈楔形,双凹变形。结论 DR因其方法简便,可直接观察骨骼密度和形态,是老年性骨质疏松症诊断的重要手段之一。但对老年性骨质疏松症的早期诊断帮助不大。 展开更多
关键词 老年性骨质疏 X线数字摄影 诊断
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专业化健教方式在深圳市偏远社区老年骨质疏松症防治中的作用 被引量:1
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作者 郭传印 吴彩琴 徐文志 《中国医药导报》 CAS 2010年第22期214-215,共2页
目的:了解专业化健教方式在深圳市偏远社区老年骨质疏松症防治中的作用,探讨在深圳市偏远社区进行老年骨质疏松症健教干预的适宜模式。方法:采取问卷调查的方式对深圳市西丽地区部分偏远社区320名60岁以上老人进行专业化健教,干预前后... 目的:了解专业化健教方式在深圳市偏远社区老年骨质疏松症防治中的作用,探讨在深圳市偏远社区进行老年骨质疏松症健教干预的适宜模式。方法:采取问卷调查的方式对深圳市西丽地区部分偏远社区320名60岁以上老人进行专业化健教,干预前后老年骨质疏松症知晓率、防治态度和健教方式、效果认可度调查分析。结果:实施专业化健教干预前后老年骨质疏松症知晓率、防治态度和健教方式、效果认可度对比有显著性差异(P<0.01)。结论:专业化健教干预方式对深圳市偏远社区老年骨质疏松症防治有明显促进作用,是老年骨质疏松症防治切实可行的有效措施之一。 展开更多
关键词 老年骨质疏 专业化健教 偏远社区 防治
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不同取穴方式及针刺手法在原发性骨质疏松症治疗中的运用现状 被引量:2
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作者 王继宏 张晓毓 《中医研究》 2018年第10期75-78,共4页
通过综述不同取穴方式和针刺手法对原发性骨质疏松症的临床、及实验研究,分析总结不同取穴方式及针刺手法治疗原发性骨质疏松症的临床特点、运用机理及各自的独特之处,为针刺运用于治疗骨质疏松症的临床方案优化提供理论依据。
关键词 针刺手法/临床应用 取穴 原发性骨质疏症/中医药疗法 治疗 现状 综述
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糖尿病与骨质疏松 被引量:3
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作者 尹萍 韩刚 《辽宁实用糖尿病杂志》 2000年第2期58-58,共1页
关键词 糖尿病 骨质疏 病理 治疗
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壮骨止痛胶囊治疗骨质疏松的临床观察
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作者 云鸿 李佳 +1 位作者 李洋 王美丽 《中国科技期刊数据库 医药》 2021年第3期5-5,共1页
目的骨质疏松症在使用了壮骨止痛胶囊后的治疗效果。方法有骨质疏松症患者80名将参与到试验当中,将其分成为2组,以平均方式分为各40例。实验组,根据课题给予壮骨止痛胶囊8g/次,3次/日;然后对照组采用常规治疗方案,仙灵骨宝胶囊2次/天,5g... 目的骨质疏松症在使用了壮骨止痛胶囊后的治疗效果。方法有骨质疏松症患者80名将参与到试验当中,将其分成为2组,以平均方式分为各40例。实验组,根据课题给予壮骨止痛胶囊8g/次,3次/日;然后对照组采用常规治疗方案,仙灵骨宝胶囊2次/天,5g/次,两组的治疗时长都是一个疗程3个月。治疗后将两组治疗前后的数据做出对比。结果:在总有效率上实验组的表现略高于对照组,数据分别为95及93百分比。而治疗的疗效的效果也是不相上下。结论:在治疗骨质疏松症上面壮骨止痛胶囊的疗效和仙灵骨宝胶囊一样。 展开更多
关键词 壮骨止痛胶囊 骨质疏 松症 骨密度
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老年骨质疏松性胸腰椎压缩性骨折采用中西医综合疗法治疗效果分析
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作者 崔超 《中文科技期刊数据库(文摘版)医药卫生》 2021年第11期272-273,共2页
分析中西医综合疗法对老年骨质疏松性胸腰椎压缩性骨折的治疗效果。方法:选取老年骨质疏松性胸腰椎压缩性骨折患者50例,采用掷骰子的方式分为两组,分别给予西药治疗与中西医综合疗法治疗。结果:甲组的治疗总有效率为96%,乙组的治疗总有... 分析中西医综合疗法对老年骨质疏松性胸腰椎压缩性骨折的治疗效果。方法:选取老年骨质疏松性胸腰椎压缩性骨折患者50例,采用掷骰子的方式分为两组,分别给予西药治疗与中西医综合疗法治疗。结果:甲组的治疗总有效率为96%,乙组的治疗总有效率为72%,P<0.05。治疗1周后、1个月后和3个月后甲组患者的椎体压缩率分别为(0.10±0.04)%、(0.10±0.03)%、(0.10±0.02)%明显优于乙组,P<0.05。结论:在老年骨质疏松性胸腰椎压缩性骨折的治疗效果应用中西医综合疗法,能够促进患者压缩椎体正常形态的恢复,具有良好的临床治疗效果,值得推广应用。 展开更多
关键词 老年骨质疏 胸腰椎压缩性骨折 中西医综合疗法
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希明婷片对卵巢功能低下所致骨质疏松症的疗效观察
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作者 张春燕 杨钟莉 《中国医师进修杂志》 2011年第21期4-6,共3页
目的观察希明婷片治疗卵巢功能低下所致骨质疏松症的临床疗效。方法将60例卵巢功能低下所致骨质疏松症患者按随机数字表法分为试验组(口服希明婷片治疗)和对照组(口服激素替代治疗),每组30例。分别于治疗前及治疗后6个月检测骨密... 目的观察希明婷片治疗卵巢功能低下所致骨质疏松症的临床疗效。方法将60例卵巢功能低下所致骨质疏松症患者按随机数字表法分为试验组(口服希明婷片治疗)和对照组(口服激素替代治疗),每组30例。分别于治疗前及治疗后6个月检测骨密度、骨钙素、雌二醇、卵泡刺激素(FSH)、子宫内膜厚度、血常规、尿常规、肝功能、肾功能。结果试验组和对照组治疗后骨密度、骨钙素[骨密度:(0.606±0.059)、(0.617±0.065)g/cm^2;骨钙素:(8.87±5.54)、(8.92±4.43)g/L]均较治疗前[骨密度:(0.537±0.068)、(0.552±0.073)g/cm^2;骨钙素:(6.78±3.97)、(6.83±4.29)g/L]提高(P〈0.05);试验组治疗前后雌二醇、FSH比较差异无统计学意义(P〉0.05),对照组治疗前后比较差异有统计学意义(P〈0.01)。试验组疗效、主要症状总有效率分别为93.3%(28/30)、93.3%(28/30),对照组分别为90.0%(27/30)、86.7%(26/30),两组比较差异均无统计学意义(P〉0.05)。两组治疗前后血常规、尿常规、肝功能、肾功能比较差异均无统计学意义(P〉0.05)。结论希明婷片对卵巢功能低下所致骨质疏松症的治疗效果明显并且安全。 展开更多
关键词 围绝经期 卵巢功能早衰 骨质疏 希明婷
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葛根素对老年骨质疏松性髋部骨折手术后周围骨密度影响 被引量:5
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作者 陈洪 庞巨涛 +3 位作者 张新虎 孙建华 周连军 刘斌 《基因组学与应用生物学》 CAS CSCD 北大核心 2019年第12期5695-5699,共5页
为了探讨葛根素对老年骨质疏松性髋部骨折手术后周围骨密度的影响,本研究将100例老年骨质疏松性髋部骨折后进行人工髋关节置换术的患者随机分为试验组和对照组(每组50例),手术后对照组患者给予常规抗骨质疏松治疗,试验组在对照组治疗的... 为了探讨葛根素对老年骨质疏松性髋部骨折手术后周围骨密度的影响,本研究将100例老年骨质疏松性髋部骨折后进行人工髋关节置换术的患者随机分为试验组和对照组(每组50例),手术后对照组患者给予常规抗骨质疏松治疗,试验组在对照组治疗的基础上加用葛根素注射液,20 d为1个疗程,两组患者均治疗2个疗程,观察并比较两组患者手术后人工假体周围骨密度情况。此外,对葛根素处理成骨细胞的结节形成情况进行比较分析。结果显示,手术后12个月,试验组患者R1、R2及R5区的骨密度略高于对照组,但差异无统计学意义(p>0.05);R3、R4、R6及R7区的骨密度明显高于对照组,差异均有统计学意义(p<0.05)。手术后24个月,试验组患者R2区的骨密度略高于对照组,但差异无统计学意义(p>0.05),R1、R3、R4、R5、R6及R7区的骨密度明显高于对照组,差异均有统计学意义(p<0.05)。经10-5 mol/L葛根素处理的实验组成骨细胞,其结节的形成速度和规模得以明显提高。结果表明,在老年骨质疏松性髋部骨折人工髋关节置换术后采用葛根素进行治疗,可增强成骨细胞活性,以提高患者人工假体周围的骨密度。 展开更多
关键词 葛根素 骨质 髋部骨折 骨密度
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Artificial intelligence models based on non-contrast chest CT for measuring bone mineral density
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作者 DUAN Wei YANG Guoqing +6 位作者 LI Yang SHI Feng YANG Lian XIONG Xin CHEN Bei LI Yong FU Quanshui 《中国医学影像技术》 CSCD 北大核心 2024年第8期1231-1235,共5页
Objective To observe the value of artificial intelligence(AI)models based on non-contrast chest CT for measuring bone mineral density(BMD).Methods Totally 380 subjects who underwent both non-contrast chest CT and quan... Objective To observe the value of artificial intelligence(AI)models based on non-contrast chest CT for measuring bone mineral density(BMD).Methods Totally 380 subjects who underwent both non-contrast chest CT and quantitative CT(QCT)BMD examination were retrospectively enrolled and divided into training set(n=304)and test set(n=76)at a ratio of 8∶2.The mean BMD of L1—L3 vertebrae were measured based on QCT.Spongy bones of T5—T10 vertebrae were segmented as ROI,radiomics(Rad)features were extracted,and machine learning(ML),Rad and deep learning(DL)models were constructed for classification of osteoporosis(OP)and evaluating BMD,respectively.Receiver operating characteristic curves were drawn,and area under the curves(AUC)were calculated to evaluate the efficacy of each model for classification of OP.Bland-Altman analysis and Pearson correlation analysis were performed to explore the consistency and correlation of each model with QCT for measuring BMD.Results Among ML and Rad models,ML Bagging-OP and Rad Bagging-OP had the best performances for classification of OP.In test set,AUC of ML Bagging-OP,Rad Bagging-OP and DL OP for classification of OP was 0.943,0.944 and 0.947,respectively,with no significant difference(all P>0.05).BMD obtained with all the above models had good consistency with those measured with QCT(most of the differences were within the range of Ax-G±1.96 s),which were highly positively correlated(r=0.910—0.974,all P<0.001).Conclusion AI models based on non-contrast chest CT had high efficacy for classification of OP,and good consistency of BMD measurements were found between AI models and QCT. 展开更多
关键词 OSTEOPOROSIS bone density tomography X-ray computed artificial intelligence
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Dissecting Causal Relationships Between Plasma Metabolites and Osteoporosis:A Bidirectional Mendelian Randomization Study
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作者 Hao Lv Ge Zhang +3 位作者 Zhi-Mu Hu Qing-Song Chu Jiu-Xiang Wang Ting Jiang 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第3期185-192,共8页
Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wid... Objective To investigate the causal relationships between plasma metabolites and osteoporosis via Mendelian randomization(MR) analysis.Methods Bidirectional MR was used to analyze pooled data from different genome-wide association studies(GWAS). The causal effect of plasma metabolites on osteoporosis was estimated using the inverse variance weighted method, intersections of statistically significant metabolites obtained from different sources of osteoporosis-related GWAS aggregated data was determined, and then sensitivity analysis was performed on these metabolites. Heterogeneity between single nucleotide polymorphisms was evaluated by Cochran's Q test. Horizontal pleiotropy was assessed through the application of the MR-Egger intercept method and the MRPRESSO method. The causal effect of osteoporosis on plasma metabolites was also evaluated using the inverse variance weighted method. Additionally, pathway analysis was conducted to identify potential metabolic pathways involved in the regulation of osteoporosis.Results Primary analysis and sensitivity analysis showed that 77 and 61 plasma metabolites had a causal relationship with osteoporosis from the GWAS data in the GCST90038656 and GCST90044600 datasets, respectively. Five common metabolites were identified via intersection. X-13684 levels and the glucose-to-maltose ratio were negatively associated with osteoporosis, whereas glycoursodeoxycholate levels and arachidoylcarnitine(C20) levels were positively associated with osteoporosis(all P < 0.05). The relationship between X-11299 levels and osteoporosis showed contradictory results(all P < 0.05). Pathway analysis indicated that glycine, serine, and threonine metabolism, valine, leucine, and isoleucine biosynthesis, galactose metabolism, arginine biosynthesis, and starch and sucrose metabolism pathways were participated in the development of osteoporosis.Conclusion We found a causal relationship between plasma metabolites and osteoporosis. These results offer novel perspectives with important implications for targeted metabolite-focused interventions in the management of osteoporosis. 展开更多
关键词 OSTEOPOROSIS plasma metabolites mendelian randomization bidirectional analysis
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Integrative analysis of bone-formation associated genes and immune cell infiltration in osteoporosis, and the prediction of active ingredients in targeted traditional Chinese medicine
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作者 WANG Kai DONG Ping GUO Hongzhang 《Digital Chinese Medicine》 CAS CSCD 2024年第2期160-170,共11页
Objective To explore the differential expression and mechanisms of bone formation-related genes in osteoporosis(OP)leveraging bioinformatics and machine learning methodologies;and to predict the active ingredients of ... Objective To explore the differential expression and mechanisms of bone formation-related genes in osteoporosis(OP)leveraging bioinformatics and machine learning methodologies;and to predict the active ingredients of targeted traditional Chinese medicine(TCM)herbs.Methods The Gene Expression Omnibus(GEO)and GeneCards databases were employed to conduct a comprehensive screening of genes and disease-associated loci pertinent to the pathogenesis of OP.The R package was utilized as the analytical tool for the identification of differentially expressed genes.Least absolute shrinkage and selection operator(LASSO)logis-tic regression analysis and support vector machine-recursive feature elimination(SVM-RFE)algorithm were employed in defining the genetic signature specific to OP.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses for the selected pivotal genes were conducted.The cell-type identification by estimating rela-tive subsets of RNA transcripts(CIBERSORT)algorithm was leveraged to examine the infiltra-tion patterns of immune cells;with Spearman’s rank correlation analysis utilized to assess the relationship between the expression levels of the genes and the presence of immune cells.Coremine Medical Database was used to screen out potential TCM herbs for the treatment of OP.Comparative Toxicogenomics Database(CTD)was employed for forecasting the TCM ac-tive ingredients targeting the key genes.AutoDock Vina 1.2.2 and GROMACS 2020 softwares were employed to conclude analysis results;facilitating the exploration of binding affinity and conformational dynamics between the TCM active ingredients and their biological targets.Results Ten genes were identified by intersecting the results from the GEO and GeneCards databases.Through the application of LASSO regression and SVM-RFE algorithm;four piv-otal genes were selected:coat protein(CP);kallikrein 3(KLK3);polymeraseγ(POLG);and transient receptor potential vanilloid 4(TRPV4).GO and KEGG pathway enrichment analy-ses revealed that these trait genes were predominantly engaged in the regulation of defense response activation;maintenance of cellular metal ion balance;and the production of chemokine ligand 5.These genes were notably associated with signaling pathways such as ferroptosis;porphyrin metabolism;and base excision repair.Immune infiltration analysis showed that key genes were highly correlated with immune cells.Macrophage M0;M1;M2;and resting dendritic cell were significantly different between groups;and there were signifi-cant differences between different groups(P<0.05).The interaction counts of resveratrol;curcumin;and quercetin with KLK3 were 7;3;and 2;respectively.It shows that the interac-tions of resveratrol;curcumin;and quercetin with KLK3 were substantial.Molecular docking and molecular dynamics simulations further confirmed the robust binding affinity of these bioactive compounds to the target genes.Conclusion Pivotal genes including CP;KLK3;POLG;and TRPV4;exhibited commendable significant prognostic value;and played a crucial role in the diagnostic assessment of OP.Resveratrol;curcumin;and quercetin;natural compounds found in TCM;showed promise in their potential to effectively modulate the bone-forming gene KLK3.This study provides a sci-entific basis for the interpretation of the pathogenesis of OP and the development of clinical drugs. 展开更多
关键词 OSTEOPOROSIS Bone formation Differentially expressed genes Biological information Traditional Chinese medicine(TCM) Active ingredients Molecular mechanism
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Role of bisphosphonates in osteoporosis caused by adult growth hormone deficiency
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作者 CHENG Zhiling LI Jie +1 位作者 CHEN Zhongpei REN Wei 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第6期839-847,共9页
In recent years,growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling,crucial for maintaining healthy bone mass throughout life.Studies have shown that adult growt... In recent years,growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling,crucial for maintaining healthy bone mass throughout life.Studies have shown that adult growth hormone deficiency leads to alterations in bone remodeling,significantly affecting bone microarchitecture and increasing fracture risk.Although recombinant human growth hormone replacement therapy can mitigate these adverse effects,improving bone density,and reduce fracture risk,its effectiveness in treating osteoporosis,especially in adults with established growth hormone deficiency,seems limited.Bisphosphonates inhibit bone resorption by targeting farnesyl pyrophosphate synthase in osteoclasts,and clinical trials have confirmed their efficacy in improving osteoporosis.Therefore,for adult growth hormone deficiency patients with osteoporosis,the use of bisphosphonates alongside growth hormone replacement therapy is recommended. 展开更多
关键词 growth hormone adult growth hormone deficiency OSTEOPOROSIS BISPHOSPHONATES insulin-like growth factor 1 SKELETON
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Unveiling osteoprotective potential of biologically active naringenin in rats with dexamethasone-induced osteoporosis
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作者 Tejal R.Waykar Satish K.Mandlik Deepa S.Mandlik 《Digital Chinese Medicine》 CAS CSCD 2024年第2期171-183,共13页
Objective To investigate the protective effects of naringenin(NRG)against dexamethasone(DEX)-induced osteoporosis(OP)in rats.Methods Molecular docking of NRG was done with AutoDock Vina 1.2.0 software.Forty-eight fema... Objective To investigate the protective effects of naringenin(NRG)against dexamethasone(DEX)-induced osteoporosis(OP)in rats.Methods Molecular docking of NRG was done with AutoDock Vina 1.2.0 software.Forty-eight female Wistar rats were randomly divided into six groups(n=8 each):normal control(NC),DEX(7 mg/kg,i.m.),NRG-low(NRG-L;25 mg/kg,i.g.),NRG-medium(NRG-M;50 mg/kg,i.g.),NRG-high(NRG-H;100 mg/kg,i.g.),and alendronate(ALN;0.25 mg/d,i.g.)groups.OP was induced by administering DEX once a week for five weeks in all groups except NC group.Begining in the third week after the initial DEX administration,the rats in NRG-L,NRG-M,NRG-H,and ALN groups received the corresponding treatments daily for three weeks,while NC and DEX groups received no additional treatment.Serum samples were collected at the end of the experiment for biochemical,bone turnover,antioxidant,lipid profile,and inflammatory cytokine analyses.Femur bones underwent physical parameter testing and histopathological examination.Results The molecular docking results illustrated that NRG docked with calcitonin(CT),lowdensity lipoprotein(LDL),bone morphogenetic protein(BMP),vascular endothelial growth factor(VEGF)receptor,forkhead transcription factors,and osteoprogenitor cells showed good binding energy.In rats administered with 25,50,and 100 mg/kg NRG,there was a significant enhancement in serum biochemical indices,characterized by a reduction in tartrate-resistant acid phosphatase(TRAP),parathyroid hormone(PTH),and an elevation in osteocalcin(OC)and CT levels(P<0.05,P<0.01,and P<0.001,respectively).Despite no significant changes in thickness,weight,and length(P>0.05),there was a marked increase in bone mineral density(BMD)(P<0.01,P<0.001,and P<0.001,respectively).Antioxidant enzyme markers showed significant upregulation,with higher glutathione,superoxide dismutase,and catalase,and a concurrent decrease in malondialdehyde(MDA)(P<0.05,P<0.01,and P<0.001,respectively).The lipid profile also improved significantly,with lower cholesterol(CH),triglycerides(TG),and low-density lipoprotein(LDL)levels,and an increase in high-density lipoprotein(HDL)level(P<0.05,P<0.01,and P<0.001,respectively).Inflammatory cytokine levels were reduced,as evidenced by decreases in tumor necrosis factor(TNF),interleukin(IL)-6,and IL-1β(P<0.05,P<0.01,and P<0.001,respectively).Furthermore,histological alterations revealed obvious improvements,and the body weight of rats treated with NRG showed an increase compared with DEX group.Conclusion These findings imply that NRG exhibited a protective effect against DEX-induced OP in rats as it promotes the bone formation process by increasing the number of bone turnover markers including OC and CT,and restoring of antioxidant status,lipid metabolism,and inflammatory markers. 展开更多
关键词 NARINGENIN OSTEOPOROSIS DEXAMETHASONE Bone turnover markers Inflammatory cytokines
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后路椎弓根螺钉植入物置入内固定腰骶椎融合后相邻节段的病变 被引量:1
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作者 邵水霖 吴继功 +6 位作者 姬勇 张乐乐 高博 李海侠 陶有平 曹参 马华松 《中国组织工程研究》 CAS CSCD 2012年第44期8316-8323,共8页
背景:椎弓根螺钉植入物置入内固定椎体融合目前仍然为大多数脊柱疾病的主要治疗方法,术后并发症依然是学者们关注的重点,相邻节段疾病是主要并发症之一,严重影响椎体融合内固定的疗效。目的:探讨后路椎弓根螺钉植入物置入内固定腰骶椎... 背景:椎弓根螺钉植入物置入内固定椎体融合目前仍然为大多数脊柱疾病的主要治疗方法,术后并发症依然是学者们关注的重点,相邻节段疾病是主要并发症之一,严重影响椎体融合内固定的疗效。目的:探讨后路椎弓根螺钉植入物置入内固定腰骶椎融合后相邻节段病变的发病原因和治疗效果。方法:回顾分析1998年4月至2011年12月采用后路椎弓根螺钉植入物置入内固定并椎间融合器植骨融合治疗的536例患者,男341例,女195例,年龄34-71岁,平均年龄51.3岁。其中单节段融合412例,多节段融合124例。对有相邻节段病变的患者均行腰椎正侧位、过伸过屈位X射线片及腰椎核磁共振检查,在X射线片上测量相邻椎间隙角度变化、上位椎体滑移距离及变化,通过JOA评分及腰功能障碍指数评价治疗前后的临床效果。经统计学分析,探讨相邻节段病变患者的发病原因、发病率、潜在风险以及治疗方法。结果与结论:采用后路椎弓根螺钉植入物置入内固定腰骶椎融合治疗的536例患者中,发现有症状的相邻节段病变患者31例。单节段融合18例,多节段融合13例。腰椎间盘突出症6例,腰椎失稳13例,腰椎滑脱9例,腰椎狭窄症3例。相邻节段病变患者均经过6个月以上的规律保守治疗,12例获得好转并稳定,其余19例接受手术治疗。随访9-64个月,平均26.7个月,按JOA评分,优4例,良11例,可3例,差1例,优良率78.94%。腰功能障碍指数平均下降33.8(8.5-42.3),改善率79.91%。统计学t检验显示相邻节段病变患者的平均年龄、融合节段比例、JOA评分和腰功能障碍指数差异均有显著性意义(P<0.05)。椎弓根螺钉植入物置入内固定腰骶椎融合后远期发生相邻节段病变,其发病与邻近椎体生物力学的变化等因素相关。多数相邻节段病变患者再次手术治疗后效果良好,早期综合考虑致病的潜在因素是防止相邻节段病变发病的主要手段。 展开更多
关键词 椎弓根螺钉 脊椎 腰骶椎融合 相邻节段病变 应力改变 椎间盘退变 间隙狭窄 椎体滑脱 骨质疏 治疗
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