目的探讨高凝状态与IgA血管炎肾炎(immunoglobulin A vasculitis with nephritis,IgAVN)患儿尿蛋白和肾脏病理损伤之间的关系。方法根据凝血功能结果,将349例IgAV患儿分为高凝组(52例)和非高凝组(297例),比较两组间尿蛋白和肾脏病理特征...目的探讨高凝状态与IgA血管炎肾炎(immunoglobulin A vasculitis with nephritis,IgAVN)患儿尿蛋白和肾脏病理损伤之间的关系。方法根据凝血功能结果,将349例IgAV患儿分为高凝组(52例)和非高凝组(297例),比较两组间尿蛋白和肾脏病理特征,并分析IgAVN患儿高凝状态形成的影响因素。结果高凝组患儿尿红细胞计数、24 h尿蛋白定量、尿蛋白/肌酐、尿免疫球蛋白G/肌酐、尿N-乙酰β-D-氨基葡萄糖苷酶水平高于非高凝组(P<0.05);高凝组患儿肾脏病理分级为Ⅲ~Ⅳ级、弥漫性系膜增生、毛细血管内皮细胞增生、肾小球新月体形成>25%比例高于非高凝组(P<0.05)。多因素logistic回归分析结果显示,毛细血管内皮细胞增生、肾小球新月体形成>25%是IgAVN患儿高凝状态形成的影响因素(P<0.05)。结论伴高凝状态IgAVN患儿的肾损伤更为严重,肾小球新月体形成>25%和毛细血管内皮细胞增生是进一步加重IgAVN高凝状态的重要因素。展开更多
近年来,膜性肾病的发病率逐渐升高,膜性肾病及其并发症受到广泛重视,血栓及栓塞是膜性肾病病程中常见的并发症。膜性肾病患者易处于高凝状态,现代医学对于膜性肾病高凝状态的抗凝治疗及预防性抗凝治疗尚未得到统一标准。中医可基于“阴...近年来,膜性肾病的发病率逐渐升高,膜性肾病及其并发症受到广泛重视,血栓及栓塞是膜性肾病病程中常见的并发症。膜性肾病患者易处于高凝状态,现代医学对于膜性肾病高凝状态的抗凝治疗及预防性抗凝治疗尚未得到统一标准。中医可基于“阴邪”,即瘀血、水湿、痰浊等角度,从本虚标实入手,利用中医内、外治法,辨证论治,个体化治疗膜性肾病高凝状态。In recent years, the incidence of membranous nephropathy has gradually increased, and membranous nephropathy and its complications have been widely valued. Thrombosis and embolism are common complications in the course of membranous nephropathy. Patients with membranous nephropathy are easy to be in a hypercoagulation state, and modern medicine for anticoagulation treatment and preventive anticoagulation treatment has not been unified standard. Chinese medicine can be based on “Yin evil”, that is, blood stasis, water moisture, phlegm turbidity, from the virtual standard and solid, using TCM internal and external treatment, syndrome differentiation, individualized treatment of hypercoagulable state of membranous nephropathy.展开更多
炎症性肠病(IBD)是一种累及回肠、结肠、直肠,病因尚未明确的肠道慢性疾病,其总发病率在各国均有所增加。研究证实炎症性肠病(IBD)患者循环系统处于高凝状态,这种高凝状态使得肠道微循环功能障碍,进一步加重炎症性肠病的疾病严重程度,...炎症性肠病(IBD)是一种累及回肠、结肠、直肠,病因尚未明确的肠道慢性疾病,其总发病率在各国均有所增加。研究证实炎症性肠病(IBD)患者循环系统处于高凝状态,这种高凝状态使得肠道微循环功能障碍,进一步加重炎症性肠病的疾病严重程度,甚至导致静脉血栓的发生。多项研究表明,IBD患者相较健康人群,其静脉血栓的发生风险增加。因此,对于炎症性肠病的患者来说,预防和治疗高凝状态具有重要意义。Inflammatory bowel disease (IBD) is a chronic intestinal disease affecting the ileum, colon, and rectum of unknown etiology, and its overall incidence has increased in all countries. Studies have confirmed that the circulatory system of patients with inflammatory bowel disease (IBD) is in a hypercoagulable state, which makes the intestinal microcirculation dysfunction, further aggravates the severity of inflammatory bowel disease, and even leads to the occurrence of venous thrombosis. Several studies have shown that patients with IBD are at increased risk of venous thrombosis compared with healthy people. Therefore, it is important for patients with inflammatory bowel disease to prevent and treat hypercoagulability.展开更多
文摘目的探讨高凝状态与IgA血管炎肾炎(immunoglobulin A vasculitis with nephritis,IgAVN)患儿尿蛋白和肾脏病理损伤之间的关系。方法根据凝血功能结果,将349例IgAV患儿分为高凝组(52例)和非高凝组(297例),比较两组间尿蛋白和肾脏病理特征,并分析IgAVN患儿高凝状态形成的影响因素。结果高凝组患儿尿红细胞计数、24 h尿蛋白定量、尿蛋白/肌酐、尿免疫球蛋白G/肌酐、尿N-乙酰β-D-氨基葡萄糖苷酶水平高于非高凝组(P<0.05);高凝组患儿肾脏病理分级为Ⅲ~Ⅳ级、弥漫性系膜增生、毛细血管内皮细胞增生、肾小球新月体形成>25%比例高于非高凝组(P<0.05)。多因素logistic回归分析结果显示,毛细血管内皮细胞增生、肾小球新月体形成>25%是IgAVN患儿高凝状态形成的影响因素(P<0.05)。结论伴高凝状态IgAVN患儿的肾损伤更为严重,肾小球新月体形成>25%和毛细血管内皮细胞增生是进一步加重IgAVN高凝状态的重要因素。
文摘近年来,膜性肾病的发病率逐渐升高,膜性肾病及其并发症受到广泛重视,血栓及栓塞是膜性肾病病程中常见的并发症。膜性肾病患者易处于高凝状态,现代医学对于膜性肾病高凝状态的抗凝治疗及预防性抗凝治疗尚未得到统一标准。中医可基于“阴邪”,即瘀血、水湿、痰浊等角度,从本虚标实入手,利用中医内、外治法,辨证论治,个体化治疗膜性肾病高凝状态。In recent years, the incidence of membranous nephropathy has gradually increased, and membranous nephropathy and its complications have been widely valued. Thrombosis and embolism are common complications in the course of membranous nephropathy. Patients with membranous nephropathy are easy to be in a hypercoagulation state, and modern medicine for anticoagulation treatment and preventive anticoagulation treatment has not been unified standard. Chinese medicine can be based on “Yin evil”, that is, blood stasis, water moisture, phlegm turbidity, from the virtual standard and solid, using TCM internal and external treatment, syndrome differentiation, individualized treatment of hypercoagulable state of membranous nephropathy.
文摘炎症性肠病(IBD)是一种累及回肠、结肠、直肠,病因尚未明确的肠道慢性疾病,其总发病率在各国均有所增加。研究证实炎症性肠病(IBD)患者循环系统处于高凝状态,这种高凝状态使得肠道微循环功能障碍,进一步加重炎症性肠病的疾病严重程度,甚至导致静脉血栓的发生。多项研究表明,IBD患者相较健康人群,其静脉血栓的发生风险增加。因此,对于炎症性肠病的患者来说,预防和治疗高凝状态具有重要意义。Inflammatory bowel disease (IBD) is a chronic intestinal disease affecting the ileum, colon, and rectum of unknown etiology, and its overall incidence has increased in all countries. Studies have confirmed that the circulatory system of patients with inflammatory bowel disease (IBD) is in a hypercoagulable state, which makes the intestinal microcirculation dysfunction, further aggravates the severity of inflammatory bowel disease, and even leads to the occurrence of venous thrombosis. Several studies have shown that patients with IBD are at increased risk of venous thrombosis compared with healthy people. Therefore, it is important for patients with inflammatory bowel disease to prevent and treat hypercoagulability.
