Many opioids-mediated responses, including the inhibition of forskolin-stimulated cyclic-AMP accumulation, the activation of an inwardly rectifying K^+ channel, and antinociception, are diminished by repeated exposure...Many opioids-mediated responses, including the inhibition of forskolin-stimulated cyclic-AMP accumulation, the activation of an inwardly rectifying K^+ channel, and antinociception, are diminished by repeated exposure to selective agonists. This loss of receptor sensitivity and function results in desensitization, down-regulation and the development of opiate tolerance. In our research, we are supposed to find out展开更多
文摘Many opioids-mediated responses, including the inhibition of forskolin-stimulated cyclic-AMP accumulation, the activation of an inwardly rectifying K^+ channel, and antinociception, are diminished by repeated exposure to selective agonists. This loss of receptor sensitivity and function results in desensitization, down-regulation and the development of opiate tolerance. In our research, we are supposed to find out
