In order to improve the autonomous navigation capability of satellite,a pulsar/CNS（celestial navigation system） integrated navigation method based on federated unscented Kalman filter（UKF） is proposed.The celestia...In order to improve the autonomous navigation capability of satellite,a pulsar/CNS（celestial navigation system） integrated navigation method based on federated unscented Kalman filter（UKF） is proposed.The celestial navigation is a mature and stable navigation method.However,its position determination performance is not satisfied due to the low accuracy of horizon sensor.Single pulsar navigation is a new navigation method,which can provide highly accurate range measurements.The major drawback of single pulsar navigation is that the system is completely unobservable.As two methods are complementary to each other,the federated UKF is used here for fusing the navigation data from single pulsar navigation and CNS.Compared to the traditional celestial navigation method and single pulsar navigation,the integrated navigation method can provide better navigation performance.The simulation results demonstrate the feasibility and effectiveness of the navigation method.展开更多
The typical shear behaviour of rough joints has been studied under constant normal load/stress （CNL） boundary conditions, but recent studies have shown that this boundary condition may not replicate true practical s...The typical shear behaviour of rough joints has been studied under constant normal load/stress （CNL） boundary conditions, but recent studies have shown that this boundary condition may not replicate true practical situations. Constant normal stiffness （CNS） is more appropriate to describe the stress-strain response of field joints since the CNS boundary condition is more realistic than CNL. The practical implications of CNS are movements of unstable blocks in the roof or walls of an underground excavation, reinforced rock wedges sliding in a rock slope or foundation, and the vertical movement of rock-socketed concrete piles. In this paper, the highlights and limitations of the existing models used to predict the shear strength/behaviour of joints under CNS conditions are discussed in depth.展开更多
According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions（SDIC）, i.e., the butterfly-effect： a tiny difference on initial conditions might lead to huge difference of computer-gene...According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions（SDIC）, i.e., the butterfly-effect： a tiny difference on initial conditions might lead to huge difference of computer-generated simulations after a long time. Thus, computer-generated chaotic results given by traditional algorithms in double precision are a kind of mixture of ＂true＂（convergent） solution and numerical noises at the same level. Today, this defect can be overcome by means of the ＂clean numerical simulation＂（CNS） with negligible numerical noises in a long enough interval of time. The CNS is based on the Taylor series method at high enough order and data in the multiple precision with large enough number of digits, plus a convergence check using an additional simulation with even smaller numerical noises. In theory, convergent（reliable） chaotic solutions can be obtained in an arbitrary long（but finite） interval of time by means of the CNS. The CNS can reduce numerical noises to such a level even much smaller than micro-level uncertainty of physical quantities that propagation of these physical micro-level uncertainties can be precisely investigated. In this paper, we briefly introduce the basic ideas of the CNS, and its applications in long-term reliable simulations of Lorenz equation, three-body problem and Rayleigh-Bénard turbulent flows. Using the CNS, it is found that a chaotic three-body system with symmetry might disrupt without any external disturbance, say, its symmetry-breaking and system-disruption are ＂self-excited＂, i.e., out-of-nothing. In addition, by means of the CNS, we can provide a rigorous theoretical evidence that the micro-level thermal fluctuation is the origin of macroscopic randomness of turbulent flows. Naturally, much more precise than traditional algorithms in double precision, the CNS can provide us a new way to more accurately investigate chaotic dynamic systems.展开更多
It is generally acknowledged that geomagnetic polarity has reversed many times in geological history and an abnormal geologic phenomenon is the Cretaceous normal superchron. However, the causes have been unknown up to...It is generally acknowledged that geomagnetic polarity has reversed many times in geological history and an abnormal geologic phenomenon is the Cretaceous normal superchron. However, the causes have been unknown up to now. The nonlinear theory has been applied to analyze the phenomenon in geomagnetic polarity reversal and the Cretaceous normal superchron. The Cretaceous normal superchron implies that interaction of the Earth＇s core-mantle and liquid movement in the outer core may be the lowest energy state and the system of Earth magnetic field maintains a sort of temporal or spatial order structure by exchanging substance and energy in the outside continuously. During 121-83 Ma, there was no impact of a celestial body that would result in a geomagnetic polarity reversal, which may be a cause for occurrence of the Cretaceous normal superchron.The randomness of geomagnetic polarity reversal has the self-reversion characteristic of chaos and the chaos theory gives a simple and clear explanation for the dynamic cause of the geomagnetic polarity reversal.展开更多
Central nervous system （CNS） presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobio...Central nervous system （CNS） presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanoflber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of selfassembling peptide nanoflber hydrogels for CNS regeneration.展开更多
Traumatic injuries to the brain and spinal cord of the central nervous system （CNS） lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound im...Traumatic injuries to the brain and spinal cord of the central nervous system （CNS） lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.展开更多
The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system （CNS） to produce cardiotoxicity. Eighty New Zealand rabbits were divided into four groups r...The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system （CNS） to produce cardiotoxicity. Eighty New Zealand rabbits were divided into four groups randomly. In Group 1,20 rabbits received intracerebroventricular （icv） saline, and then received icv ropivacaine 30 min later. In Group 2, 20 rabbits received icv ropivacaine. Whenever dysrhythmias continued for more than 5 min, 0.1 ml saline was administered into the left cerebral ventricle. Ten minutes later, 0.1 ml midazolam was given into the left lateral ventricle. In Group 3, 20 rabbits received icv ropivacaine, and once the dysrhythmias developed, the inspired isoflurane concentration was increased from 0.75% to 1.50%. In Group 4, 20 animals received an intravenous （iv） phenylephrine infusion until dysrhythmias occurred. In Group 1, the rabbits did not develop dysrhythmias in response to icv saline, whereas dysrhythmias did develop in these animals after icv ropivacaine. In Group 2, icv saline had no effect on the dysrhythmias; however, icv midazolam terminated cardiac dysrhythmias. In Group 3, an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias. In Group 4, icv midazolam had no effect on dysrhythmias in response to iv phenylephdne. Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias; midazolam terminated dysrhythmias presumably by potentiation of y-aminobutyric acid （GABA） receptor activity. Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug, but also by the CNS effects of ropivacaine.展开更多
An association between assisted reproductive technology （ART） and neurobehavioral imprinting disorders has been reported in many studies, and it seems that ART may interfere with imprint reprogramming. However, it h...An association between assisted reproductive technology （ART） and neurobehavioral imprinting disorders has been reported in many studies, and it seems that ART may interfere with imprint reprogramming. However, it has never been explored whether epigenetic erros or imprinting disease susceptibility induced by ART can be inherited transgenerationally. Hence, the aim of this study was to determine the effect of in vitro fertilization and embryo transfer （IVF-ET） on transgenerational inheritance in am inbred mouse model. Mice derived from IVF-ET were outcrossed to wild-type C57BL/6J to obtain their female and male line F2 and F3 generations. Their behavior, morphology, histology, and DNA methylation status at several important differentially methylated regions （DMRs） were analyzed by Morris water maze, hematoxylin and eosin （H＆E） staining, and bisulfite genomic sequencing. No significant differences in spatial learning or phenotypic abnormality were found in adults derived from IVF （F1） and female and male line F2 and F3 generations. A borderline trend of hypomethylation was found in H19 DMR CpG island 3 in the female line-derived F3 generation （0.40±0.118, P=0.086）. Methylation status in H19/Igf2 DMR island 1, Igf2 DMR, KvDMR, and Snrpn DMR displayed normal patterns. Methylation percentage did not differ significantly from that of adults conceived naturally, and the expression of the genes they regulated was not disturbed. Transgenerational integrity, such as behavior, morphology, histology, and DNA methylation status, was maintained in these generations, which indicates that exposure of female germ cells to hormonel stimulation and gamete manipulation might not affect the individuals and their descendents.展开更多
The famous three-body problem can be traced back to Isaac Newton in the 1680 s. In the 300 years since this "three-body problem"was first recognized, only three families of periodic solutions had been found,...The famous three-body problem can be traced back to Isaac Newton in the 1680 s. In the 300 years since this "three-body problem"was first recognized, only three families of periodic solutions had been found, until 2013 when ˇSuvakov and Dmitraˇsinovi′c [Phys.Rev. Lett. 110, 114301(2013)] made a breakthrough to numerically find 13 new distinct periodic orbits, which belong to 11 new families of Newtonian planar three-body problem with equal mass and zero angular momentum. In this paper, we numerically obtain 695 families of Newtonian periodic planar collisionless orbits of three-body system with equal mass and zero angular momentum in case of initial conditions with isosceles collinear configuration, including the well-known figure-eight family found by Moore in 1993, the 11 families found by ˇSuvakov and Dmitraˇsinovi′c in 2013, and more than 600 new families that have never been reported, to the best of our knowledge. With the definition of the average period T = T=Lf, where Lf is the length of the so-called "free group element", these 695 families suggest that there should exist the quasi Kepler's third law T* ≈ 2:433 ± 0:075 for the considered case, where T*= T|E|^(3/2) is the scale-invariant average period and E is its total kinetic and potential energy,respectively. The movies of these 695 periodic orbits in the real space and the corresponding close curves on the "shape sphere"can be found via the website: http://numericaltank.sjtu.edu.cn/three-body/three-body.htm.展开更多
基金supported by the National High Technology Research and Development Program of China(2006AAJ109)Aviation Science Fund(20070818001)
文摘In order to improve the autonomous navigation capability of satellite,a pulsar/CNS（celestial navigation system） integrated navigation method based on federated unscented Kalman filter（UKF） is proposed.The celestial navigation is a mature and stable navigation method.However,its position determination performance is not satisfied due to the low accuracy of horizon sensor.Single pulsar navigation is a new navigation method,which can provide highly accurate range measurements.The major drawback of single pulsar navigation is that the system is completely unobservable.As two methods are complementary to each other,the federated UKF is used here for fusing the navigation data from single pulsar navigation and CNS.Compared to the traditional celestial navigation method and single pulsar navigation,the integrated navigation method can provide better navigation performance.The simulation results demonstrate the feasibility and effectiveness of the navigation method.
文摘The typical shear behaviour of rough joints has been studied under constant normal load/stress （CNL） boundary conditions, but recent studies have shown that this boundary condition may not replicate true practical situations. Constant normal stiffness （CNS） is more appropriate to describe the stress-strain response of field joints since the CNS boundary condition is more realistic than CNL. The practical implications of CNS are movements of unstable blocks in the roof or walls of an underground excavation, reinforced rock wedges sliding in a rock slope or foundation, and the vertical movement of rock-socketed concrete piles. In this paper, the highlights and limitations of the existing models used to predict the shear strength/behaviour of joints under CNS conditions are discussed in depth.
基金Project supported by the National Natural Science Foundation of China(Grant No.1432009)
文摘According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions（SDIC）, i.e., the butterfly-effect： a tiny difference on initial conditions might lead to huge difference of computer-generated simulations after a long time. Thus, computer-generated chaotic results given by traditional algorithms in double precision are a kind of mixture of ＂true＂（convergent） solution and numerical noises at the same level. Today, this defect can be overcome by means of the ＂clean numerical simulation＂（CNS） with negligible numerical noises in a long enough interval of time. The CNS is based on the Taylor series method at high enough order and data in the multiple precision with large enough number of digits, plus a convergence check using an additional simulation with even smaller numerical noises. In theory, convergent（reliable） chaotic solutions can be obtained in an arbitrary long（but finite） interval of time by means of the CNS. The CNS can reduce numerical noises to such a level even much smaller than micro-level uncertainty of physical quantities that propagation of these physical micro-level uncertainties can be precisely investigated. In this paper, we briefly introduce the basic ideas of the CNS, and its applications in long-term reliable simulations of Lorenz equation, three-body problem and Rayleigh-Bénard turbulent flows. Using the CNS, it is found that a chaotic three-body system with symmetry might disrupt without any external disturbance, say, its symmetry-breaking and system-disruption are ＂self-excited＂, i.e., out-of-nothing. In addition, by means of the CNS, we can provide a rigorous theoretical evidence that the micro-level thermal fluctuation is the origin of macroscopic randomness of turbulent flows. Naturally, much more precise than traditional algorithms in double precision, the CNS can provide us a new way to more accurately investigate chaotic dynamic systems.
基金supported by the National Basic Research Program of China(Grant No.2006CB701406)the National Natural Science Foundation of China(Grant Nos.40672196 and 40638041)+1 种基金the Laboratory of Resources Environment and Management(Grant No.GPMR0520)and the Project 111(Grant No.B07011).
文摘It is generally acknowledged that geomagnetic polarity has reversed many times in geological history and an abnormal geologic phenomenon is the Cretaceous normal superchron. However, the causes have been unknown up to now. The nonlinear theory has been applied to analyze the phenomenon in geomagnetic polarity reversal and the Cretaceous normal superchron. The Cretaceous normal superchron implies that interaction of the Earth＇s core-mantle and liquid movement in the outer core may be the lowest energy state and the system of Earth magnetic field maintains a sort of temporal or spatial order structure by exchanging substance and energy in the outside continuously. During 121-83 Ma, there was no impact of a celestial body that would result in a geomagnetic polarity reversal, which may be a cause for occurrence of the Cretaceous normal superchron.The randomness of geomagnetic polarity reversal has the self-reversion characteristic of chaos and the chaos theory gives a simple and clear explanation for the dynamic cause of the geomagnetic polarity reversal.
基金Acknowledgements This work was supported by the National Natural Science Foundation of China （Grant Nos. 51303119 and 51203108）, Natural Science Foundation of Jiangsu Province （BK20130309, BK201341421, BK2011355）, Natural Science Foundation of the Jiangsu Higher Education Institutions （13KJB430019）, National Science Foundation for Post-doctoral Scientists of China （2013M541724 and 2014T70545）, Tsinghua University Initiative Scientific Research Program （20121087982）, and 973 Program （2011CB606205）.
文摘Central nervous system （CNS） presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanoflber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of selfassembling peptide nanoflber hydrogels for CNS regeneration.
文摘Traumatic injuries to the brain and spinal cord of the central nervous system （CNS） lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.
基金Project (No. 2006K13-G7-4) supported by the Key Sci-Tech Research Project of Shaanxi Province,China
文摘The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system （CNS） to produce cardiotoxicity. Eighty New Zealand rabbits were divided into four groups randomly. In Group 1,20 rabbits received intracerebroventricular （icv） saline, and then received icv ropivacaine 30 min later. In Group 2, 20 rabbits received icv ropivacaine. Whenever dysrhythmias continued for more than 5 min, 0.1 ml saline was administered into the left cerebral ventricle. Ten minutes later, 0.1 ml midazolam was given into the left lateral ventricle. In Group 3, 20 rabbits received icv ropivacaine, and once the dysrhythmias developed, the inspired isoflurane concentration was increased from 0.75% to 1.50%. In Group 4, 20 animals received an intravenous （iv） phenylephrine infusion until dysrhythmias occurred. In Group 1, the rabbits did not develop dysrhythmias in response to icv saline, whereas dysrhythmias did develop in these animals after icv ropivacaine. In Group 2, icv saline had no effect on the dysrhythmias; however, icv midazolam terminated cardiac dysrhythmias. In Group 3, an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias. In Group 4, icv midazolam had no effect on dysrhythmias in response to iv phenylephdne. Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias; midazolam terminated dysrhythmias presumably by potentiation of y-aminobutyric acid （GABA） receptor activity. Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug, but also by the CNS effects of ropivacaine.
基金supported by the National Basic Research Program (973) of China (No. 2007CB948104)the National Natural Science Foundation of China (No. 81070532)the Zhejiang Provincial Natural Science Foundation of China (No. Z207021)
文摘An association between assisted reproductive technology （ART） and neurobehavioral imprinting disorders has been reported in many studies, and it seems that ART may interfere with imprint reprogramming. However, it has never been explored whether epigenetic erros or imprinting disease susceptibility induced by ART can be inherited transgenerationally. Hence, the aim of this study was to determine the effect of in vitro fertilization and embryo transfer （IVF-ET） on transgenerational inheritance in am inbred mouse model. Mice derived from IVF-ET were outcrossed to wild-type C57BL/6J to obtain their female and male line F2 and F3 generations. Their behavior, morphology, histology, and DNA methylation status at several important differentially methylated regions （DMRs） were analyzed by Morris water maze, hematoxylin and eosin （H＆E） staining, and bisulfite genomic sequencing. No significant differences in spatial learning or phenotypic abnormality were found in adults derived from IVF （F1） and female and male line F2 and F3 generations. A borderline trend of hypomethylation was found in H19 DMR CpG island 3 in the female line-derived F3 generation （0.40±0.118, P=0.086）. Methylation status in H19/Igf2 DMR island 1, Igf2 DMR, KvDMR, and Snrpn DMR displayed normal patterns. Methylation percentage did not differ significantly from that of adults conceived naturally, and the expression of the genes they regulated was not disturbed. Transgenerational integrity, such as behavior, morphology, histology, and DNA methylation status, was maintained in these generations, which indicates that exposure of female germ cells to hormonel stimulation and gamete manipulation might not affect the individuals and their descendents.
基金supported by the National Natural Science Foundation of China(Grant No.11432009)
文摘The famous three-body problem can be traced back to Isaac Newton in the 1680 s. In the 300 years since this "three-body problem"was first recognized, only three families of periodic solutions had been found, until 2013 when ˇSuvakov and Dmitraˇsinovi′c [Phys.Rev. Lett. 110, 114301(2013)] made a breakthrough to numerically find 13 new distinct periodic orbits, which belong to 11 new families of Newtonian planar three-body problem with equal mass and zero angular momentum. In this paper, we numerically obtain 695 families of Newtonian periodic planar collisionless orbits of three-body system with equal mass and zero angular momentum in case of initial conditions with isosceles collinear configuration, including the well-known figure-eight family found by Moore in 1993, the 11 families found by ˇSuvakov and Dmitraˇsinovi′c in 2013, and more than 600 new families that have never been reported, to the best of our knowledge. With the definition of the average period T = T=Lf, where Lf is the length of the so-called "free group element", these 695 families suggest that there should exist the quasi Kepler's third law T* ≈ 2:433 ± 0:075 for the considered case, where T*= T|E|^(3/2) is the scale-invariant average period and E is its total kinetic and potential energy,respectively. The movies of these 695 periodic orbits in the real space and the corresponding close curves on the "shape sphere"can be found via the website: http://numericaltank.sjtu.edu.cn/three-body/three-body.htm.
