Objective: According to clinical phenotypic classification, there is a significant overlap of clinical features between different anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and disease cl...Objective: According to clinical phenotypic classification, there is a significant overlap of clinical features between different anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and disease classification based on ANCA subtype helps to differentiate clinical phenotypes. We investigated the clinical features and outcomes of patients based on ANCA serotype classification. Methods: Clinical and laboratory data were collected retrospectively. We compared clinical manifestations and organ involvement based on serotype. The risk factors for death and renal survival were investigated with univariate and multivariate Cox regression models. Results: Patients with MPO-ANCA were predominant, whose median age and lung involvement at diagnosis was higher than that of the PR3-ANCA patients. Compared to the AAV patients without renal involvement, those with renal involvement have older, anemia, low complement C3, and hypoproteinemia, more likely to have cardiovascular and abdominal involvement, and have less lung involvement. Multivariate Cox analysis revealed that age ≥ 65 years (HR = 2.611, p p = 0.019), BVAS ≥ 15 (HR = 1.943, p = 0.001), low C3 (HR = 1.696, p = 0.008), and hypoproteinemia (HR = 1.438, p = 0.044) were associated with mortality. SCR ≥ 500 μmol/L (HR = 13.583, p p = 0.020), low C3 (HR = 1.506, p = 0.049) were independent detrimental factors for renal survival, and immunosuppressive treatment was a protective factor for renal survival (HR = 0.523, p = 0.003). Conclusions: Clinical manifestations varied by AAV categories. Age, SCR, BVAS, low C3 and hypoproteinemia at diagnosis were independent predictors of mortality. BVAS, low C3, SCR at diagnosis and immunosuppressive treatment were independently related to renal survival in ANCA positive patients.展开更多
采用高温固相法合成了La_(2)MgTiO_(6)∶Mn^(4+)、La_(2)MgTiO_(6)∶Pr^(3+)、La_(2)MgTiO_(6)∶Pr^(3+),Mn^(4+)单掺杂和双掺杂荧光粉,并通过X射线衍射、扫描电镜、荧光光谱等测试方法对荧光粉的物相结构、形貌和发光特性进行了表征及...采用高温固相法合成了La_(2)MgTiO_(6)∶Mn^(4+)、La_(2)MgTiO_(6)∶Pr^(3+)、La_(2)MgTiO_(6)∶Pr^(3+),Mn^(4+)单掺杂和双掺杂荧光粉,并通过X射线衍射、扫描电镜、荧光光谱等测试方法对荧光粉的物相结构、形貌和发光特性进行了表征及分析。结果表明:成功合成了La_(2)MgTiO_(6)∶Mn^(4+)、La_(2)MgTiO_(6)∶Pr^(3+)、La_(2)MgTiO_(6)∶Pr^(3+),Mn^(4+)荧光粉且均为纯相;样品的粒径为1~2μm;La_(2)MgTiO_(6)∶Mn^(4+)在650~750 nm的红光发射是来自Mn^(4+)的2 E 1→4 A 2跃迁,La_(2)MgTiO_(6)∶Pr^(3+)在红光区域600~660 nm具有强烈的发射,归属为Pr^(3+)的3 P 0→3 H 6和3 P 0→3 F 2跃迁。当Mn^(4+)与Pr^(3+)共同掺杂于La_(2)MgTiO_(6)时,来自Mn^(4+)、Pr^(3+)不同波段的红光发射使荧光粉的发射光谱与植物光敏色素P r与P fr吸收光谱的重叠程度大幅增加,表明Mn^(4+)、Pr^(3+)共掺有效拓宽了La_(2)MgTiO_(6)荧光粉的红光发射区域,更符合植物照明的需求,在LED植物照明领域具有更明显的潜在应用价值。展开更多
文章主要研究了Y_(2)SiO_(5):Pr^(3+)上转换纳米荧光粉对ZnO:Pr^(3+)的光催化性能的影响,通过XRD、FE-SEM、FL和UV-Vis对样品的物相、形貌、发光性能和光催化行性能进行了分析表征,实验结果表明:随着Y_(2)SiO_(5):Pr^(3+)上转换纳米荧...文章主要研究了Y_(2)SiO_(5):Pr^(3+)上转换纳米荧光粉对ZnO:Pr^(3+)的光催化性能的影响,通过XRD、FE-SEM、FL和UV-Vis对样品的物相、形貌、发光性能和光催化行性能进行了分析表征,实验结果表明:随着Y_(2)SiO_(5):Pr^(3+)上转换纳米荧光粉的加入量增加,ZnO:Pr^(3+)光催化效率逐渐提高,当加入0.2 g Y_(2)SiO_(5):Pr^(3+)时,光催化效率最高,在光照60 min后对亚甲基蓝的降解率达到了98.11%,相比未加入Y_(2)SiO_(5):Pr^(3+)时的光催化效率有显著提升。展开更多
文摘Objective: According to clinical phenotypic classification, there is a significant overlap of clinical features between different anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), and disease classification based on ANCA subtype helps to differentiate clinical phenotypes. We investigated the clinical features and outcomes of patients based on ANCA serotype classification. Methods: Clinical and laboratory data were collected retrospectively. We compared clinical manifestations and organ involvement based on serotype. The risk factors for death and renal survival were investigated with univariate and multivariate Cox regression models. Results: Patients with MPO-ANCA were predominant, whose median age and lung involvement at diagnosis was higher than that of the PR3-ANCA patients. Compared to the AAV patients without renal involvement, those with renal involvement have older, anemia, low complement C3, and hypoproteinemia, more likely to have cardiovascular and abdominal involvement, and have less lung involvement. Multivariate Cox analysis revealed that age ≥ 65 years (HR = 2.611, p p = 0.019), BVAS ≥ 15 (HR = 1.943, p = 0.001), low C3 (HR = 1.696, p = 0.008), and hypoproteinemia (HR = 1.438, p = 0.044) were associated with mortality. SCR ≥ 500 μmol/L (HR = 13.583, p p = 0.020), low C3 (HR = 1.506, p = 0.049) were independent detrimental factors for renal survival, and immunosuppressive treatment was a protective factor for renal survival (HR = 0.523, p = 0.003). Conclusions: Clinical manifestations varied by AAV categories. Age, SCR, BVAS, low C3 and hypoproteinemia at diagnosis were independent predictors of mortality. BVAS, low C3, SCR at diagnosis and immunosuppressive treatment were independently related to renal survival in ANCA positive patients.
文摘采用高温固相法合成了La_(2)MgTiO_(6)∶Mn^(4+)、La_(2)MgTiO_(6)∶Pr^(3+)、La_(2)MgTiO_(6)∶Pr^(3+),Mn^(4+)单掺杂和双掺杂荧光粉,并通过X射线衍射、扫描电镜、荧光光谱等测试方法对荧光粉的物相结构、形貌和发光特性进行了表征及分析。结果表明:成功合成了La_(2)MgTiO_(6)∶Mn^(4+)、La_(2)MgTiO_(6)∶Pr^(3+)、La_(2)MgTiO_(6)∶Pr^(3+),Mn^(4+)荧光粉且均为纯相;样品的粒径为1~2μm;La_(2)MgTiO_(6)∶Mn^(4+)在650~750 nm的红光发射是来自Mn^(4+)的2 E 1→4 A 2跃迁,La_(2)MgTiO_(6)∶Pr^(3+)在红光区域600~660 nm具有强烈的发射,归属为Pr^(3+)的3 P 0→3 H 6和3 P 0→3 F 2跃迁。当Mn^(4+)与Pr^(3+)共同掺杂于La_(2)MgTiO_(6)时,来自Mn^(4+)、Pr^(3+)不同波段的红光发射使荧光粉的发射光谱与植物光敏色素P r与P fr吸收光谱的重叠程度大幅增加,表明Mn^(4+)、Pr^(3+)共掺有效拓宽了La_(2)MgTiO_(6)荧光粉的红光发射区域,更符合植物照明的需求,在LED植物照明领域具有更明显的潜在应用价值。
文摘文章主要研究了Y_(2)SiO_(5):Pr^(3+)上转换纳米荧光粉对ZnO:Pr^(3+)的光催化性能的影响,通过XRD、FE-SEM、FL和UV-Vis对样品的物相、形貌、发光性能和光催化行性能进行了分析表征,实验结果表明:随着Y_(2)SiO_(5):Pr^(3+)上转换纳米荧光粉的加入量增加,ZnO:Pr^(3+)光催化效率逐渐提高,当加入0.2 g Y_(2)SiO_(5):Pr^(3+)时,光催化效率最高,在光照60 min后对亚甲基蓝的降解率达到了98.11%,相比未加入Y_(2)SiO_(5):Pr^(3+)时的光催化效率有显著提升。
